Abstract: A system and method of predicting propensity of metastasis of a tumor in a patient by at least one processor may include: receiving, from a first scan modality, a first scan comprising a set of scan images depicting metabolic information; receiving, from a second scan modality, a second scan comprising a set of scan images depicting anatomical information; segmenting the first scan to identify a volumetric segment representing a suspected tumor, based on the depicted metabolic information; extracting one or more radiomics features from the second scan, corresponding to the volumetric segment, based on the depicted anatomical information; and predicting propensity of metastasis of the suspected tumor, based on the one or more radiomics features.