Abstract: Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.

Abstract: The present invention relates to a manufacturing method of kimchi with shelf stability and high quality under the severe environment, more precisely, a manufacturing method of kimchi with shelf stability and high quality under the severe environment such as desert, alpine regions, poles and space which includes the step of irradiation after heating, gas exchange packaging and quick freezing. The manufacturing method of kimchi of the present invention reduces the chances of deterioration of the sensory quality and physicochemical characteristics caused by the conventional sterilization methods including high temperature and high pressure treatment and high dose of irradiation, so that kimchi produced by this method has excellent shelf stability under the severe environment.

Abstract: Disclosed relates to an ionic liquid type crown ether derivative, expressed by Chemical Formula 1 below, for isolating metal ions, a method for preparing the same and a method for isolating selectively the metal ions using the cycle size of the same. The present invention can provide the ionic liquid type crown ether and isolate metal ions including radioactive isotopes efficiently using the same. Furthermore, the prevent invention provides crown ether valuably used as a recyclable and environment-friendly isolating medium by preparing crown ether of ionic liquid type. wherein m, n, X? and R are identical with those in the description.

Abstract: The present invention relates to a biochip for the detection of phosphorylation and a method for measuring phosphorylation using the same, more precisely a biochip integrated with the substrate of kinase and a kit for measuring phosphorylation comprising the biochip and a radio-labeled co-factor, and a method for measuring phosphorylation using the same. The kit for the detection of phosphorylation of the present invention facilitates simple and fast measurement of phosphorylation with a minimum amount of a sample, compared with the conventional method using an antibody, because it uses a radioisotope. This chip and kit can be effectively used for the analysis of kinase activity since this method favors fast mass analysis.

Abstract: Disclosed are a fibroin with increased molecular weight and improved antioxidant activity, tyrosinase inhibitory ability and cytotoxicity to cancer cells, which has a molecular structure modified by irradiation, a method for production thereof, use of the irradiated fibroin in various applications for enhancing antioxidant activity, tyrosinase inhibitory ability and/or cytotoxicity to cancer cells such as foods, cosmetics, medicines, etc.

Abstract: The present invention relates to a method of antioxidative functional estimation using an animal model, more precisely a method of antioxidative functional estimation using mice having oxidative damage caused by reactive oxygen species induced by irradiation and having lipid hydroperoxide secreted in the urine which might be index for quantitative and qualitative analysis for antioxidative functional estimation. The method of antioxidative functional estimation of the present invention can be effectively used for the screening of a novel anti-oxidant agent or antioxidative functional health food to regulate the production of lipid hydroperoxide.

Abstract: Disclosed are sericin having improved antioxidant and tyrosinase inhibitory abilities and increased molecular weight by irradiation, which causes a modification of a sericin molecular structure, a preparation method thereof and use of the irradiated sericin in various applications including food products, cosmetics and/or pharmaceutical products and medicines to improve antioxidant ability and/or tyrosinase inhibitory functions.

Abstract: Disclosed herein is a method for the preparation of low-molecular weight beta-glucan by irradiation. The low-molecular weight beta-glucan prepared by irradiation shows a random distribution of all beta-glucan structures, low viscosity and high water solubility, and acts as an excellent antioxidant and to activate immune cells, finding useful application in many fields including the food, medical and cosmetics industries.

Abstract: Disclosed is an irradiation method which includes addition of vitamin C during sterilization of bone restorative demineralized bone matrix (DBM) with irradiation, so as to inhibit reduction of physical properties of a carrier containing DBM caused by irradiation and protect DBM formable bone morphogenetic protein (BMP) from irradiation. The method according to the present invention can provide bone restorative materials with more excellent stability and effectively controlled modification of physical properties by employing a sterilization process accompanied with addition of vitamin C during irradiation.

Abstract: Disclosed is a method for producing demineralized bone matrix with improvement of releasing bone morphogenetic protein by irradiating the demineralized bone matrix, the demineralized bone matrix produced by the producing method, a method for extracting bone morphogenetic protein using the demineralized bone matrix, and the bone morphogenetic protein extracted by the extracting method. The demineralized bone matrix produced according to the present invention and the bone morphogenetic protein extracted by using the demineralized bone matrix can be advantageously used in manufacturing bone restorative implants, bone growth accelerating compositions, and/or health aids or supplementary food products.

Abstract: The present invention relates to a vaccine composition for the prevention and treatment of allergic disease comprising irradiated ovalbumin as an effective ingredient, more precisely a method for preparing an immunogen of a vaccine for the prevention and treatment of allergic disease using the irradiated ovalbumin which is separated and purified from the albumen of an egg, a vaccine composition for the prevention and treatment of allergic disease comprising the irradiated ovalbumin as an effective ingredient, and a method for the prevention and treatment of allergic disease using the vaccine comprising the irradiated ovalbumin. In the mouse vaccinated with the irradiated ovalbumin, humoral and cell mediated immune responses were both reduced, suggesting that allergic reaction was inhibited. Thus, the composition of the present invention can be effectively used as a vaccine for the prevention and treatment of allergic disease.

Abstract: Disclosed relates to organic germanium nanocolloids, to which technetium-99m (99mTc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention, 99mTc-labeled organic germanium nanocolloids having high labeling efficiency and stability can be provided. Moreover, since the 99mTc-labeled organic germanium nanocolloids of the invention are accumulated in the spleen considerably higher than the conventional spleen-imaging agent, it is possible to use the 99mTc-labeled organic germanium nanocolloids of the present invention as a therapeutic radiopharmaceutical for the spleen imaging.

Abstract: Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.

Abstract: The present invention relates to a manufacturing method of kimchi with shelf stability and high quality under the severe environment, more precisely, a manufacturing method of kimchi with shelf stability and high quality under the severe environment such as desert, alpine regions, poles and space which includes the step of irradiation after heating, gas exchange packaging and quick freezing. The manufacturing method of kimchi of the present invention reduces the chances of deterioration of the sensory quality and physicochemical characteristics caused by the conventional sterilization methods including high temperature and high pressure treatment and high dose of irradiation, so that kimchi produced by this method has excellent shelf stability under the severe environment.

Abstract: Disclosed herein is a method of preparing a 188Re-tricarbonyl complex for radiopharmaceutical use and of preparing a precursor thereof, and a contrast agent using the same. Particularly, this invention provides a method of preparing a 188Re-tricarbonyl precursor by reacting perrhenate with borane-ammonia (BH3.NH3), potassium boranocarbonate (K2[H3BCO2]) and phosphate in the presence of borohydride exchange resin as a reducing agent, and a method of preparing a 188Re-tricarbonyl complex by reacting the 188Re-tricarbonyl precursor with a ligand. According to the method of this invention, the borohydride exchange resin is used as a reducing agent and as an anion scavenger, thereby obtaining the 188Re-tricarbonyl precursor and complex having high radiolabeling yield and high purity. In addition, the 188Re-tricarbonyl complex can be used as a contrast agent having excellent plasma stability.

Abstract: Disclosed is a herbal composition comprising a first hot-water extract from a mixture of the plants Angelicae gigantis Radix, Cnidium officinale Makino and Paeonia japonica Miyabe et Takeda at an equal weight ratio, and a polysaccharide fraction as a precipitate formed by adding ethanol to a second hot-water extract from a mixture of the plants Angelicae gigantis Radix, Cnidium officinale Makino and Paeonia japonica Miyabe et Takeda at an equal weight ratio. The herbal composition of the present invention is effective in improving the anticancer activity, immune response and hematopoiesis of the body, and protecting the body from oxidative damage.

Abstract: Disclosed is a herbal composition comprising a first hot-water extract from a mixture of the plants Angelicae gigantis Radix, Cnidium officinale Makino and Paeonia japonica Miyabe et Takeda at an equal weight ratio, and a polysaccharide fraction as a precipitate formed by adding ethanol to a second hot-water extract from a mixture of the plants Angelicae gigantis Radix, Cnidium officinale Makino and Paeonia japonica Miyabe et Takeda at an equal weight ratio. The herbal composition of the present invention is effective in improving the anticancer activity, immune response and hematopoiesis of the body, and protecting the body from oxidative damage.