Abstract: Implementations of a method of generating a product system model may include, using a first interface, receiving from a user a selection of a product type; selecting a product SPICE model associated with the product type from a database of product SPICE models; and using a second interface, receiving from the user a selection of a process condition. The method may include, using a third interface, receiving from the user one or more system characteristics and one or more operating characteristics; using a fourth interface, receiving from the user one or more circuit characteristics; using a SPICE model simulation module, generating a SPICE model output with the product SPICE model, and, using a formatting module, formatting the SPICE model output into a product system model file, the product system model file including one of a structured text file, a plain text file, or a delimited text file.

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: Delivery systems for expandable and stented implants include adjustable tensioning members that control the expansion of the implant along the length of the implant. The tensioning members are wound onto one or more rotors located on the distal segment of the delivery system, which are rotated to unwind the tensioning members and incrementally expand the implant. Positioning mechanisms are also provided to adjust the position and orientation of the implant during delivery.

Abstract: The present invention provides compounds of the structural Formula (I), and pharmaceutically acceptable salts thereof, wherein, are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutically active agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.

Abstract: A system for managing the elevation of a workstation, the system comprising a frame, a worktop having an upper worksurface, at least a first powered vertical-displacement drive mechanism connected between the frame and the worktop and arranged to selectively vertically displace the worktop with respect to the frame, a presence sensor and a processor linked to the drive mechanism and the sensor, the processor using information from the presence sensor to track user presence at the workstation and, upon detecting that the workstation is unoccupied, automatically controlling the drive mechanism to move the worktop from a current height to a scheduled height.

Abstract: An envelope holds gas in a lighter-than-air aircraft. The envelope has an outer shell, an inner wall, a compressor, and a valve. The outer shell has an upper surface, a lower surface, a leading edge, a trailing edge, opposing side surfaces, and an airfoil-shaped lateral cross-section. The inner wall divides the outer shell into high and low pressure chambers. The compressor is disposed between the high and low pressure chambers and controlled to selectively force gas from the low pressure chamber to flow into the high pressure chamber. The valve is disposed between the high pressure chamber and the low pressure chamber and controlled to selectively permit gas from the high pressure chamber to flow into the low pressure chamber.

Abstract: A method for communicating and preserving creative intent within a motion picture production chain, including a production stage, and at least one of a subsequent laboratory or post production stage, including capturing an original image of a scene during the production stage; generating a look representative of a creative intent, wherein the look is a digital representation of a creative alteration of the captured original scene image; and applying the look to the captured original scene image and confirming approval of the look during the production stage. The digital representation of the look is stored as a recipe for generating the creative alteration, and communicated from the production stage to at least one of the subsequent laboratory and post-production stages for applying the look to the captured motion picture footage during subsequent laboratory and post-production stages.

Abstract: An envelope is disclosed for holding gas in a lighter-than-air aircraft. The envelope includes a shell having a leading edge, a trailing edge, an upper surface and a lower surface. The upper surface and the lower surface each extend between the leading edge and the trailing edge. The shell has an airfoil-shaped cross-section having a reflex camber quality.

Abstract: An orientation system is disclosed for a lighter-than-air aircraft having a lower stage suspended from an envelope. The orientation system includes a swivel and a plurality of thrust generators. The swivel is affixed between the envelope and the lower stage. The swivel is oriented for allowing the lower stage to rotate with respect to the envelope. The plurality of thrust generators are affixed to the lower stage. At least some of the trust generators generating differential thrust produces a change in rotation of the lower stage with respect to the envelope.

Abstract: A method for communicating and preserving creative intent within a motion picture production chain, including a production stage, and at least one of a subsequent laboratory or post production stage, including capturing an original image of a scene during the production stage; generating a look representative of a creative intent, wherein the look is a digital representation of a creative alteration of the captured original scene image; and applying the look to the captured original scene image and confirming approval of the look during the production stage. The digital representation of the look is stored as a recipe for generating the creative alteration, and communicated from the production stage to at least one of the subsequent laboratory and post-production stages for applying the look to the captured motion picture footage during subsequent laboratory and post-production stages.

Abstract: A method for communicating and preserving creative intent within a motion picture production chain, including a production stage, and at least one of a subsequent laboratory or post production stage, including capturing an original image of a scene during the production stage; generating a look representative of a creative intent, wherein the look is a digital representation of a creative alteration of the captured original scene image; and applying the look to the captured original scene image and confirming approval of the look during the production stage. The digital representation of the look is stored as a recipe for generating the creative alteration, and communicated from the production stage to at least one of the subsequent laboratory and post-production stages for applying the look to the captured motion picture footage during subsequent laboratory and post-production stages.

Abstract: An improved application architecture comprises a bifurcated structure having a language neutral portion and a localizable portion, compacted for efficiency into a smaller set of larger files. This bifurcated structure allows for easier distribution and updating of the application, while the reduced set of files provides for more efficient file management. A resource manifest can be specified during the compile stage to identify elements that are language specific and elements that remain language neutral. Furthermore, additional software can be used after compilation for compacting multiple localizable elements into a single file. Such compacting software can receive inputs specifying the language specific resources which are to be compacted into larger files, and the identity of those larger files.

Abstract: An orientation system is disclosed for a lighter-than-air aircraft having a lower stage suspended from an envelope. The orientation system includes cords interconnecting the envelope and the lower stage and means for adjusting the length of at least one of the cords between the lower stage and the envelope. Adjusting the length produces a shift in the angle of attack of the envelope with respect to the lower stage.

Abstract: An envelope is disclosed for holding gas in a lighter-than-air aircraft. The envelope includes a shell having upper and lower hemispheres. The upper hemisphere has the shape of a hemisphere of a generally oblate spheroid defined by equatorial radii and a polar radius. The lower hemisphere has the shape of a hemisphere of a generally oblate spheroid defined by equatorial radii and a polar radius. The lower hemisphere is inverted compared to the upper hemisphere. The equatorial radii of the upper hemisphere are equal to the equatorial radii of the lower hemisphere. The upper hemisphere is joined with the lower hemisphere at their respective equators. The volume of the upper hemisphere is greater than the volume of the lower hemisphere. The height of the shell is less than the diameter of the shell at the joined equators.

Abstract: This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g., cells from cervical and other tumors). The HPV protein can be joined to a stress protein by chemical conjugation or noncovalently using linking moieties, or by fusion (e.g., a recombinant fusion protein). Also described are expression vectors containing sequences encoding HPV antigens and stress proteins, which can be introduced into cells of a subject or cells ex vivo. Also described are compositions that include a stress protein linked to an HPV antigen and another pharmacologically acceptable component and stress protein —HPV antigen fusions and conjugates. These compositions can be used to induce or enhance an immune response against HPV and cells that exhibit HPV antigens, including HPV-associated tumors.

Abstract: An improved application architecture comprises a bifurcated structure having a language neutral portion and a localizable portion, compacted for efficiency into a smaller set of larger files. This bifurcated structure allows for easier distribution and updating of the application, while the reduced set of files provides for more efficient file management. A resource manifest can be specified during the compile stage to identify elements that are language specific and elements that remain language neutral. Furthermore, additional software can be used after compilation for compacting multiple localizable elements into a single file. Such compacting software can receive inputs specifying the language specific resources which are to be compacted into larger files, and the identity of those larger files.

Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.

Abstract: This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g., cells from cervical and other tumors). The HPV protein can be joined to a stress protein by chemical conjugation or noncovalently using linking moieties, or by fusion (e.g., a recombinant fusion protein). Also described are expression vectors containing sequences encoding HPV antigens and stress proteins, which can be introduced into cells of a subject or cells ex vivo. Also described are compositions that include a stress protein linked to an HPV antigen and another pharmacologically acceptable component and stress protein—HPV antigen fusions and conjugates. These compositions can be used to induce or enhance an immune response against HPV and cells that exhibit HPV antigens, including HPV-associated tumors.

Abstract: An improved operating system architecture comprises a bifurcated structure having a substantially language neutral, non-localizable portion as well as one or more localizable portions. This bifurcated structure allows for easier distribution, updating, and patching of the operating system. Methods of producing the bifurcated operating system can be applied before or after compiling of the source code. If applied prior to compiling, tags may be used to aid in bifurcation. One or more control files provide a further mechanism for influencing the destination of components in the bifurcated structure.

Abstract: The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.