Patents by Inventor N. Connor Payne

N. Connor Payne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZINAMIDE COMPOUNDS
    Publication number: 20250228855
    Abstract: The present application provides compounds and methods for treating various diseases such as malaria and cancer.
    Type: Application
    Filed: April 19, 2023
    Publication date: July 17, 2025
    Inventors: N. Connor Payne, Mark A. Tye, Ralph Mazitschek, Dyann F. Wirth
  • FRET-BASED ASSAYS
    Publication number: 20250093263
    Abstract: The present application provides compounds and methods for identifying a modulator of a protein of interest using TR-FRET donor attached to the protein of interest and a tracer containing TR-FRET acceptor. Iterations of this compound may also includes attachment of an ATP-binding moiety, an amino acid, and/or a fluorophore.
    Type: Application
    Filed: July 22, 2022
    Publication date: March 20, 2025
    Inventors: Ralph ` Mazitschek, N. Connor Payne, Mark A. Tye
  • Complexes and Ligands
    Publication number: 20250084303
    Abstract: The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.
    Type: Application
    Filed: September 10, 2024
    Publication date: March 13, 2025
    Inventors: Ralph Mazitschek, N. Connor Payne, Alena Kalyakina
  • Complexes and ligands
    Patent number: 12134721
    Abstract: The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: November 5, 2024
    Assignee: The General Hospital Corporation
    Inventors: Ralph Mazitschek, N. Connor Payne, Alena Kalyakina
  • Inhibitors of prolyl-tRNA-synthetase
    Patent number: 11708353
    Abstract: The present application provides compounds, such as compounds of Formula Ia, which are inhibitors of aminoacyl tRNA-synthetase (e.g., prolyl-tRNA-synthetase), and which are useful for treating disorders associated with aminoacyl tRNA-synthetase activity and/or expression. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also provided.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: July 25, 2023
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Ralph Mazitschek, Sofia A. Santos, Mark A. Tye, N. Connor Payne, Dyann F. Wirth
  • Complexes and Ligands
    Publication number: 20220025254
    Abstract: The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.
    Type: Application
    Filed: October 22, 2019
    Publication date: January 27, 2022
    Inventors: Ralph Mazitschek, N. Connor Payne, Alena Kalyakina
  • Inhibitors of Prolyl-tRNA-Synthetase
    Publication number: 20210253558
    Abstract: The present application provides compounds which are inhibitors of aminoacyl tRNA-synthetase (e.g., prolyl-tRNA-synthetase) and are useful for treating disorders associated with aminoacyl tRNA-synthetase activity and/or expression. Pharmaceutical compositions comprising the compounds and methods of using the compounds are also provided.
    Type: Application
    Filed: June 10, 2019
    Publication date: August 19, 2021
    Inventors: Ralph Mazitschek, Sofia A. Santos, Mark A. Tye, N. Connor Payne, Dyann F. Wirth