Abstract: Methods and devices including amorphous magnetic microwires are provided for biomedical energy transfer for diagnosis or therapy, to promote cellular growth, or to deliver pharmaceutical agents. Applications of the technology include in sensors, actuators, and therapeutic coatings, and for increasing the amount, directionality, or length of nerve growth. The technology also can be utilized for nerve regeneration, hyperthermic treatment of tumors, vascular theranostics, probing a nerve, stimulating a nerve, sensing a biological condition, catheterization, and micro-actuation.

Abstract: Provided herein are, in various embodiments, methods and compositions for differentiating olfactory mucosa-derived mesenchymal stem cells (OM-MSC). In certain embodiments, the disclosure provides for media to differentiate OM-MSCs. In still further embodiments, the disclosure provides for methods and compositions using differentiated OM-MSCs for the treatment of nerve repair. In particular embodiments, the disclosure provides for novel treatments of peripheral nerve repair.

Abstract: Neurosupportive materials that possess strong tissue adhesion were synthesized by photocrosslinking two polymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA/MeTro ratio. In addition, GelMA/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue ex vivo compared to traditionally used fibrin-based materials. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation in vitro, which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA/MeTro hydrogels exhibited slower degradation in vivo compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves.

Abstract: An embodiment is a scientific fluidic device and a method of assembly of single and multilayer fluidic devices via laser cut and assembly of double sided adhesives. The device includes a member defining a cavity and having two sides, both sides including an adhesive compound, and at least one substrate defining at least two plenums and coupling to the member, forming a flow path. The components of the fluidic device are produced via laser cut and assembly methods. The fluidic device remains intact via adhesive coupling between the substrate(s), member(s), and membrane(s). Altogether, the fluidic device requires assembly that is efficient and economical, resulting in high throughput manufacturing of the fluidic devices.

Abstract: Devices and systems for cell culture analysis are provided. A device for cell culture analysis includes a first component comprising a receptacle configured to receive a cell culture insert having an apical surface and a basal surface and a second component. The device further includes an inlet port disposed at at least one of the first and second components and an outlet port disposed at at least one of the first and second components. The first component and second component are releasably couplable and configured to define a flow path from the inlet port to the outlet port when in a coupled state. The flow path is at least partially defined by a surface of the second component, and the first component is configured to expose the basal surface of the cell culture insert to the flow path.

Abstract: An embodiment is a scientific fluidic device and a method of assembly of single and multilayer fluidic devices via laser cut and assembly of double sided adhesives. The device includes a member defining a cavity and having two sides, both sides including an adhesive compound, and at least one substrate defining at least two plenums and coupling to the member, forming a flow path. The components of the fluidic device are produced via laser cut and assembly methods. The fluidic device remains intact via adhesive coupling between the substrate(s), member(s), and membrane(s). Altogether, the fluidic device requires assembly that is efficient and economical, resulting in high throughput manufacturing of the fluidic devices.

Abstract: Neurosupportive materials that possess strong tissue adhesion were synthesized by photocrosslinking two polymers, gelatin methacryloyl (GelMA) and methacryloyl-substituted tropoelastin (MeTro). The engineered materials exhibited tunable mechanical properties by varying the GelMA/MeTro ratio. In addition, GelMA/MeTro hydrogels exhibited 15-fold higher adhesive strength to nerve tissue ex vivo compared to traditionally used fibrin-based materials. Furthermore, the composites were shown to support Schwann cell (SC) viability and proliferation, as well as neurite extension and glial cell participation in vitro, which are essential cellular components for nerve regeneration. Finally, subcutaneously implanted GelMA/MeTro hydrogels exhibited slower degradation in vivo compared with pure GelMA, indicating its potential to support the growth of slowly regenerating nerves.

Abstract: Some aspects include reception of a plurality of search results, selection of a graphical format in which to present the search results from a plurality of graphical formats based on metadata of the plurality of search results, and presentation of the plurality of search results in the selected graphical format.

Abstract: Some aspects include reception of a plurality of search results, selection of a graphical format in which to present the search results from a plurality of graphical formats based on metadata of the plurality of search results, and presentation of the plurality of search results in the selected graphical format.

Abstract: A form-fitting foot covering (10, 34, 44) is provided including a sole portion (14, 36, 46) and a corresponding uppers portion (16, 38, 48) which is designed to be worn in a tightly fitting manner over a user's foot to provide protection and comfort. The inner surface (20) of the foot covering (16, 34, 44) may carry a medicament (22). The foot covering (10, 34, 44) may be integrally formed using a thin, resilient, stretchable resin material such as latex, vinyl or nitrile, and they may be equipped with a laminated resilient gel padding layer (30). Alternately, the uppers portion (38) may be formed of a woven cloth material (40) or a perforate synthetic resin material presenting air holes (52). An optional adhesive (60) may be used to hold the foot covering in place and create a watertight seal.

Abstract: An apparatus and method for forming foundry cores and molds of superior hardness and uniformity in a wide range of sizes includes staging hoppers for storing a first mass of sand coated with a catalyst-polymerizable resin film, and a second mass of sand coated with a catalyst film for polymerizing the resin. In forming the cores or molds these masses are simultaneoulsy and evenly dispersed into a high velocity carrier air-sand stream and directed through a static mixer, wherein the resin and catalyst-coated sand particles are intermingled and at least a partial integration of the films takes place, into a shaping mold cavity, wherein the sand mixture hardens into a desired shape.

Abstract: An apparatus and method for forming foundry cores and molds of superior hardness and uniformity in a wide range of sizes includes staging hoppers for storing a first mass of sand coated with a catalyst-polymerizable resin film, and a second mass of sand coated with a catalyst film for polymerizing the resin. In forming the cores or molds these masses are simultaneously and evenly dispersed into a high velocity carrier air-sand stream and directed through a static mixer stage, wherein the resin and catalyst-coated sand particles are intermingled and at least a partial integration of the films takes place, into a shaping mold cavity, wherein the sand mixture hardens into a desired shape. Because the process is fast and continuous and mixing is accomplished without mechanically driven mixing elements, the apparatus and method are particularly well suited to high volume foundry operations wherein resin-catalyst systems having very fast hardening times are utilized.

Abstract: An apparatus and method for forming foundry cores and molds of superior hardness and uniformity in a wide range of sizes includes staging hoppers for storing a first mass of sand coated with a catalyst-polymerizable resin film, and a second mass of sand coated with a catalyst film for polymerizing the resin. In forming the cores or molds these masses are simultaneously and evenly dispersed into a high velocity carrier air-sand stream and directed through a static mixer, wherein the resin and catalyst-coated sand particles are intermingled and at least a partial integration of the films takes place into a shaping mold cavity, wherein the sand mixture hardens into a desired shape. For improved integration of the resin and catalyst films, and for improved core density, air is injected into the air sand stream downline of the static mixer immediately prior to the sand mixture entering the shaping mold.

Abstract: An apparatus and method for forming foundry cores and molds of superior hardness and uniformity in a wide range of sizes includes staging hoppers for storing a first mass of sand coated with a catalyst-polymerizable resin film, and a second mass of sand coated with a catalyst film for polymerizing the resin. In forming the cores or molds these masses are evenly dispersed into a high velocity carrier air-sand stream and directed through a static mixer, wherein the resin and catalyst-coated sand particles are intermingled and at least a partial integration of the films takes place, into a shaping mold cavity, wherein the sand mixture hardens into a desired shape. Control circuitry is provided to independently control the dispersal of the catalyst and resin sand masses to enable the system to be fine tuned to produce cores of improved quality and uniformity.

Abstract: An apparatus and method for forming foundry cores and molds of superior hardness and uniformity in a wide range of sizes includes staging hoppers for storing under pressure a first mass of sand coated with a catalyst-polymerizable resin film, and a second mass of sand coated with a catalyst film for polymerizing the resin. In forming the cores or molds these masses are simultaneously and evenly dispersed from the hoppers into a high velocity carrier air-sand stream and directed through a static mixer, wherein the resin and catalyst-coated sand particles are intermingled and at least a partial integration of the films takes place, into a shaping mold cavity, wherein the sand mixture hardens into a desired shape. The staging hoppers each include a pressurized infeed portion void of sand to provide more even feeding from the hoppers into the air-sand stream to produce cores of improved consistency.