Patents by Inventor NÉLIG LE GOUX

NÉLIG LE GOUX has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL STIM1 SPLICING VARIANTS AND USES THEREOF
    Publication number: 20240083990
    Abstract: The present invention relates to the identification of a new splice variant of STIM1 useful as a biomarker and as a target for the treatment of diseases.
    Type: Application
    Filed: January 26, 2022
    Publication date: March 14, 2024
    Inventors: OLIVIER MIGNEN, NÉLIG LE GOUX, DELPHINE BERNARD, TIFFANY BERGOT, MATHIEU BLERY
  • SUBSTANCE INTERACTING WITH C TERMINAL FRAGMENT OF THE STIM1 FRACTION LOCALIZED TO THE PLASMA MEMBRANE OF THE CELLS, FOR ITS USE IN THE TREATMENT OF CANCERS, AND IN SCREENING AND DIAGNOSTIC METHODS
    Publication number: 20230063059
    Abstract: The present invention relates to a substance interacting with C terminal fragment of the STIM1 fraction localized to the plasma membrane of the cells, for its use in the treatment of cancers. The present invention further relates to a pharmaceutical composition comprising at least one substance interacting with C terminal fragment of the STIM1 fraction localized to the plasma membrane of cells, and at least one pharmaceutically acceptable excipient. The invention also refers to the use of isolated C terminal fragment of the STIM1 fraction localized to the plasma membrane of cells in a method for screening candidate molecules for treating cancers, especially pancreatic, colon, breast, Burkitt lymphoma or chronic Lymphocytic Leukaemia. The present invention also relates to a process for predicting the progression and/or monitoring the progression of a cancer, comprising the in vitro detection of the expression of STIM1 in a sample of the tumour of the subject.
    Type: Application
    Filed: March 23, 2020
    Publication date: March 2, 2023
    Inventors: OLIVIER MIGNEN, PAUL BUSCAGLIA, PATRICE HEMON, NELIG LE GOUX