Patents by Inventor N. Randall Chu

N. Randall Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7262014
    Abstract: This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g., cells from cervical and other tumors). The HPV protein can be joined to a stress protein by chemical conjugation or noncovalently using linking moieties, or by fusion (e.g., a recombinant fusion protein). Also described are expression vectors containing sequences encoding HPV antigens and stress proteins, which can be introduced into cells of a subject or cells ex vivo. Also described are compositions that include a stress protein linked to an HPV antigen and another pharmacologically acceptable component and stress protein—HPV antigen fusions and conjugates. These compositions can be used to induce or enhance an immune response against HPV and cells that exhibit HPV antigens, including HPV-associated tumors.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: August 28, 2007
    Assignee: Stressgen Biotechnologies Corporation
    Inventors: Lee A. Mizzen, N. Randall Chu, Huacheng Bill Wu
  • Patent number: 6900035
    Abstract: This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g., cells from cervical and other tumors). The HPV protein can be joined to a stress protein by chemical conjugation or noncovalently using linking moieties, or by fusion (e.g., a recombinant fusion protein). Also described are expression vectors containing sequences encoding HPV antigens and stress proteins, which can be introduced into cells of a subject or cells ex vivo. Also described are compositions that include a stress protein linked to an HPV antigen and another pharmacologically acceptable component and stress protein—HPV antigen fusions and conjugates. These compositions can be used to induce or enhance an immune response against HPV and cells that exhibit HPV antigens, including HPV-associated tumors.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: May 31, 2005
    Assignee: Stressgen Biotechnologies, Inc.
    Inventors: Lee A. Mizzen, N. Randall Chu, Huacheng Bill Wu
  • Patent number: 6657055
    Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: December 2, 2003
    Assignee: Stressgen Biotechnologies Corporation
    Inventors: Marvin Siegel, N. Randall Chu, Lee A. Mizzen
  • Publication number: 20030148456
    Abstract: The present invention relates to compositions for inducing an immune response, preferably a cellular, in particular a cell-mediated, cytolytic immune response, to human papillomavirus (HPV) protein antigens displayed by HPV or exhibited by infected cells including cells from cervical and other tumors. In one embodiment, compositions comprise an HPV protein antigen joined to a stress protein (or heat shock protein (Hsp)). The HPV protein antigen may be joined to the stress protein by chemical conjugation or noncovalently using linking moieties, or the HPV protein antigen and the stress protein may be joined in a fusion protein containing both HPV protein antigen and stress protein sequences. In another embodiment, compositions comprise an expression vector including, in expressible form, sequences encoding the HPV protein antigen and sequences encoding the stress protein.
    Type: Application
    Filed: November 7, 2002
    Publication date: August 7, 2003
    Applicant: Stressgen Biotechnologies, Inc., a British Columbia, Canada corporation
    Inventors: Lee A. Mizzen, N. Randall Chu, Huacheng Bill Wu
  • Publication number: 20030050469
    Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.
    Type: Application
    Filed: October 9, 2002
    Publication date: March 13, 2003
    Applicant: Stressgen Biotechnologies Corporation, a Victoria, Canada corporation
    Inventors: Marvin Siegel, N. Randall Chu, Lee A. Mizzen
  • Patent number: 6524825
    Abstract: The present invention relates to compositions for inducing an immune response, preferably a cellular, in particular a cell-mediated, cytolytic immune response, to human papillomavirus (HPV) protein antigens displayed by HPV or exhibited by infected cells including cells from cervical and other tumors. In one embodiment, compositions comprise an HPV protein antigen joined to a stress protein (or heat shock protein (Hsp)). The HPV protein antigen may be joined to the stress protein by chemical conjugation or noncovalently using linking moieties, or the HPV protein antigen and the stress protein may be joined in a fusion protein containing both HPV protein antigen and stress protein sequences. In another embodiment, compositions comprise an expression vector including, in expressible form, sequences encoding the HPV protein antigen and sequences encoding the stress protein.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: February 25, 2003
    Assignee: Stressgen Biotechnologies, Inc.
    Inventors: Lee A. Mizzen, N. Randall Chu, Huacheng Bill Wu
  • Patent number: 6495347
    Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: December 17, 2002
    Assignee: Stressgen Biotechnologies Corporation
    Inventors: Marvin Siegel, N. Randall Chu, Lee A. Mizzen