Abstract: The invention relates generally to the following novel fendiline derivatives, and the preparation and use thereof: Formula I (I) and Formula II (II)

Abstract: Embodiments are directed to a series of novel EPAC antagonists that are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the previously identified high-throughput (HTS) hit ESI-09.

Abstract: Provided is a production process for powdered sugar and liquid syrup, comprising the steps of primary pressing sugar cane juice extraction, three-stage physical filtration, and sugar boiling, wherein the step of the three-stage physical filtration respectively uses a sieve plate, a bagasse separator and a micro-filtration membrane for filtration. The bagasse separator comprises a screen cylinder transversely arranged inside a separation bin. The inlet and outlet of the screen cylinder are respectively connected to a feeding bin and a discharging bin. A juice outlet and a bagasse outlet are respectively provided under the separation bin and the discharging bin. A propeller blade component is provided inside the screen cylinder. The propeller blade component is formed by combining vertical mixing blades with helical blades.

Abstract: Embodiments are directed to a series of novel EPAC antagonists that are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the previously identified high-throughput (HTS) hit ESI-09.

Abstract: Provided is a production process for powdered sugar and liquid syrup, comprising the steps of primary pressing sugar cane juice extraction, three-stage physical filtration, and sugar boiling, wherein the step of the three-stage physical filtration respectively uses a sieve plate, a bagasse separator and a micro-filtration membrane for filtration. The bagasse separator comprises a screen cylinder transversely arranged inside a separation bin. The inlet and outlet of the screen cylinder are respectively connected to a feeding bin and a discharging bin. A juice outlet and a bagasse outlet are respectively provided under the separation bin and the discharging bin. A propeller blade component is provided inside the screen cylinder. The propeller blade component is formed by combining vertical mixing blades with helical blades.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure (e.g., a compound having Formula I: which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).

Abstract: Provided is a piperazinotriazole compound represented by general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer or hydrate thereof. Also provided are a pharmaceutical composition comprising the compound, a method for preparing the compound and a method of use thereof as a high-selectivity poly(adenosine diphosphate-ribose)polymerase-1 (PARP-1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.

Abstract: Provided is a piperazinotriazole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose)polymerase-1 (PARP 1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.