Abstract: The present disclosure provides devices, systems, kits and methods for rapid, simple self-sampling and self-performing detection of nucleic acid sequence of interest in a sample, specifically, nucleic acid sequences of pathogenic agents.

Abstract: The present invention, in some embodiments thereof, is directed to a method for isolating a target microorganism from a sample, including contacting a sample with an antibody having specific affinity to the target microorganism, wherein the antibody is produced by immunizing a host organism using a selected target microorganism, wherein the selected target microorganism is selected by contacting the sample with one or more polynucleotide molecules each having specific affinity to one target microorganism, and determining the presence of the target microorganism in the sample.

Abstract: Provided herein are methods of modulating selected populations of immune cells by administering specific bacterial strains to a subject. Also provided herein are methods of promoting expansion and/or contraction of selected populations of immune cells following the administration of a bacterial strain to a subject.

Abstract: Described herein are methods and compositions for the induction of the production of regulatory T cells and for the treatment and/or prevention of diseases associated with pathological immune responses, such as inflammatory bowel diseases.

Abstract: Nucleic acid construct systems are disclosed. The constructs comprise: (i) a first nucleic acid construct comprising a first nucleic acid sequence encoding a first reporter polypeptide linked to an additional nucleic acid sequence capable of inserting the first nucleic acid construct into a genome of a host cell such that an endogenous polypeptide covalently attached to the first reporter polypeptide is expressed in the cell; and (ii) a second nucleic acid construct comprising a second nucleic acid sequence encoding a second reporter polypeptide, linked to an additional nucleic acid sequence capable of inserting in a non-directed manner the second nucleic acid construct into a genome of a host cell such that an endogenous polypeptide covalently attached to the second reporter polypeptide is expressed in the cell, wherein the first reporter polypeptide and the second reporter polypeptide are distinguishable.