Patents by Inventor Nabil A. Alhakamy

Nabil A. Alhakamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Icariin nano-pharmaceutical formulation
    Patent number: 11559495
    Abstract: A nano-pharmaceutical formulation, comprising zein nanoparticles, icariin (ICA) or a pharmaceutically acceptable salt thereof encapsulated within the zein nanoparticles, at least one solubilizer, wherein the at least one solubilizer comprises D-a-Tocopherol polyethylene glycol 1000 succinate (TPGS), and one or more pharmaceutical penetration enhancers is provided. Methods of enhancing libido by administering a composition as described herein is also provided.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: January 24, 2023
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Hani Z. Asfour, Nabil A. Alhakamy, Raed I. Felimban, Osama A. A. Ahmed, Waleed Y. Rizg, Usama A. Fahmy, Ashraf B. Abdel-Naim
  • Thioctamer expedites wound healing
    Patent number: 11497765
    Abstract: Thioctamer, a nanoconjugate of glatiramer acetate (GA) and thioctic acid (TA), e.g. in the form of nanospheres, is provided as are compositions comprising thioctamer and methods of using the same for wound healing. Application of thioctamer to a wound accelerates wound healing, compared to control wounds that are not treated with the copolymer.
    Type: Grant
    Filed: February 27, 2022
    Date of Patent: November 15, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed, Basma G. Eid, Mohammed Z. Nasrullah, Ashraf B. Abdel-naim, Amgad Khedr, Gamal A. Mohamed, Mohamed W. Alrabei, Sabrin R. M. Ibrahim
  • In situ gelling composition as a pH-selective and mucoadhesive sustained release drug delivery system
    Patent number: 11318090
    Abstract: An in situ gelling composition comprising nanoparticles comprising soy protein and a bioactive agent, and a sodium alginate film, wherein the nanoparticles are encapsulated in the film. The in situ gelling composition maybe incorporated into a solid dosage form or reconstituted with water for oral administration to a subject in need of sustained release of the bioactive agent.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: May 3, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Shadab Md, Samaa T. Abdullah, Nabil A. Alhakamy
  • Ketoconazole ophthalmic preparations containing trans-ethosomal drug nanoparticles
    Patent number: 11285148
    Abstract: An ophthalmic formulation comprising transethosomes is provided. The transethosomes include a phospholipid, an edge activator, ethanol, and ketoconazole, wherein a surface of the transethosome is modified with a cationic charge inducing agent. The transethosomes may be incorporated into in situ gelling or hydrogel compositions. The formulations are useful for the sustained delivery of ketoconazole to the posterior eye segment of a subject.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: March 29, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Tarek A. Ahmed, Maram M. Alzahrani, Nabil A. Alhakamy, Raed I. Felimban
  • In situ gelling composition as a pH-selective and mucoadhesive sustained release drug delivery system
    Patent number: 11260025
    Abstract: An in situ gelling composition comprising nanoparticles comprising soy protein and a bioactive agent, and a sodium alginate film, wherein the nanoparticles are encapsulated in the film. The in situ gelling composition maybe incorporated into a solid dosage form or reconstituted with water for oral administration to a subject in need of sustained release of the bioactive agent.
    Type: Grant
    Filed: February 15, 2021
    Date of Patent: March 1, 2022
    Assignee: KING ABDULAZIZ UNIVERSITY
    Inventors: Shadab MD, Samaa T. Abdullah, Nabil A. Alhakamy
  • FORMULATION FOR TOPICAL TREATMENT OF ACUTE WOUNDS
    Publication number: 20220023244
    Abstract: Nanoparticulate, ion-paired complexes of melittin (MLN) and one or more non-steroidal anti-inflammatory drugs, and particularly MLN ion-paired with diclofenac, provide for enhanced wound healing in humans and other animals. Compositions having the nanonparticulates distributed therein or thereon are applied topically to the wound, and the ion-paired complexes have been shown to demonstrate superior wound healing and closure.
    Type: Application
    Filed: July 21, 2020
    Publication date: January 27, 2022
    Inventors: Nabil A. Alhakamy, Osama A. Ahmed, Usama A. Fahmy, Shadab Md
  • Rotary resectoscope
    Patent number: 10980561
    Abstract: A rotatory resectoscope is disclosed with a novel mechanism for endoscopic resection. Resection is performed by a rotary motion instead of the conventional linear motion. A novel resection loop and working element for controlling the movement of the resection loop allow the resection loop to move in clockwise and counterclockwise rotation. Embodiments include both monopolar and bipolar diathermy resectoscopes.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: April 20, 2021
    Assignee: King Abdulaziz University
    Inventors: Omar A. Fahmy, Nabil A. Alhakamy, Osama A. Ahmed, Usama A. Fahmy, Shadab Md
  • Liquisolid tablet containing combined dose of tadalafil and dapoxetine
    Patent number: 10744137
    Abstract: A liquisolid tablet formulation, comprising a microcrystalline cellulose carrier; a silica coating; a crosslinked polyvinylpyrrolidone (PVP) superdisintegrant; a solvent comprising polyethylene glycol (PEG) 200 and caprylocaproyl macrogol-8 glycerides; tadalafil; and dapoxetine, wherein the liquid load factor of the formulation is 0.2-0.4 is provided. Methods of making the liquisolid tablet and methods of using the formulation for the treatment of male sexual dysfunction are also provided.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: August 18, 2020
    Assignee: King Abdulaziz University
    Inventors: Khalid M. El-Say, Fayez O. Alotaibi, Nabil A. Alhakamy, Abdelsattar M. Omar