Patents by Inventor Nabil A Elshourbagy

Nabil A Elshourbagy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6428982
    Abstract: Urotensin-II Receptor (UTB-R) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Urotensin-II Receptor (UTB-R) polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 6, 2000
    Date of Patent: August 6, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Nabil Elshourbagy, Usman Shabon, Derk J. Bergsma
  • Publication number: 20020098538
    Abstract: AXOR23 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR23 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 24, 2001
    Publication date: July 25, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon, David Michalovich
  • Publication number: 20020090691
    Abstract: Mus musculus EDG4 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus musculus EDG4. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.
    Type: Application
    Filed: July 12, 2001
    Publication date: July 11, 2002
    Inventors: Nabil A. Elshourbagy, Pamela Lane, Ping Tsui
  • Publication number: 20020076760
    Abstract: Human G-Protein Coupled Receptor HNFDS78 polypeptides and DNA (RNA) encoding such G-Protein Coupled Receptor HNFDS78 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such G-Protein Coupled Receptor HNFDS78 for the treatment of diseases, such as, atherosclerosis, inflammatory disease, and infectious disease. Antagonists against such G-Protein Coupled Receptor HNFDS78 and their use as a therapeutic to treat disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding G-protein coupled receptors and for detecting altered levels of the polypeptide in a host.
    Type: Application
    Filed: July 24, 2001
    Publication date: June 20, 2002
    Inventors: Derk Bergsma, Nabil Elshourbagy, Henry Sarau, Steven Ruben
  • Publication number: 20020061558
    Abstract: Mus musculus EDG7 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus musculus EDG7. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.
    Type: Application
    Filed: June 12, 2001
    Publication date: May 23, 2002
    Inventors: Nabil Elshourbagy, Pamela Lane, Ping Tsui
  • Publication number: 20020058323
    Abstract: Macaca fascicularis Urotensin II polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Macaca fascicularis Urotensin II. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: hypothalamic disorders of growth hormone deficiency; mental illness, and enhanced or exaggerated sensitivity to pain.
    Type: Application
    Filed: May 11, 2001
    Publication date: May 16, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon
  • Publication number: 20020055476
    Abstract: The RAMP2a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising RAMP2a polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: February 26, 2001
    Publication date: May 9, 2002
    Inventor: Nabil A. Elshourbagy
  • Publication number: 20020052022
    Abstract: AXOR87 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR87 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: May 22, 2001
    Publication date: May 2, 2002
    Inventors: Nabil Elshourbagy, Mahanandeshwar Gattu, Usman Shabon, Diane M. Ignar
  • Publication number: 20020052330
    Abstract: The SBELEVTM polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SBELEVTM polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: March 14, 2001
    Publication date: May 2, 2002
    Inventors: David Michalovich, Nabil Elshourbagy, Usman Shabon
  • Publication number: 20020045216
    Abstract: Mus Musculus FMRL-3 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus Musculus FMRL-3. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.
    Type: Application
    Filed: June 12, 2001
    Publication date: April 18, 2002
    Inventors: Nabil Elshourbagy, Pamela Lane, Ping Tsui
  • Publication number: 20020045214
    Abstract: Rattus norvegus AXOR29 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize rattus norvegus AXOR29. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.
    Type: Application
    Filed: March 20, 2001
    Publication date: April 18, 2002
    Inventors: Nabil Elshourbagy, Pamela A. Lane, Ping Tsui
  • Publication number: 20020042385
    Abstract: AXOR-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising AXOR-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: January 12, 2001
    Publication date: April 11, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon, Derk J. Bergsma
  • Patent number: 6365715
    Abstract: HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: April 2, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Anthony J Arleth, Nabil A Elshourbagy, Xiaotong Li, Robert N Willette
  • Publication number: 20020037550
    Abstract: mouse AXOR70 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing mouse AXOR70 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: March 1, 2001
    Publication date: March 28, 2002
    Inventors: Nabil Elshourbagy, Mahanandeeshwar Gattu, Usman Shabon
  • Patent number: 6361967
    Abstract: AXOR10 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR10 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: March 26, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Pankaj Agarwal, Nabil A. Elshourbagy, David Michalovich, Randall Forrest Smith, Lisa Vawter
  • Publication number: 20020019032
    Abstract: Mus musculus NeuromedinU-V polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus musculus NeuromedinU-V.
    Type: Application
    Filed: April 20, 2001
    Publication date: February 14, 2002
    Inventors: Nabil A. Elshourbagy, Usman Shabon
  • Publication number: 20020004222
    Abstract: AXOR8 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR8 polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: January 18, 2001
    Publication date: January 10, 2002
    Inventors: Nabil Elshourbagy, Usman Shabon
  • Publication number: 20010034331
    Abstract: Human H218 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human H218 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 25, 2001
    Inventors: Derk J. Bergsma, Nabil Elshourbagy, Pamela Lane, Xiaotong Li, Jeffrey L. Mooney, Ping Tsui
  • Publication number: 20010025099
    Abstract: Polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: April 5, 2001
    Publication date: September 27, 2001
    Inventors: Nabil Elshourbagy, Lisa Vawter
  • Patent number: 6287801
    Abstract: Human G-Protein Coupled Receptor HNFDS78 polypeptides and DNA (RNA) encoding such G-Protein Coupled Receptor HNFDS78 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such G-Protein Coupled Receptor HNFDS78 for the treatment of diseases, such as, atherosclerosis, inflammatory disease, and infectious disease. Antagonists against such G-Protein Coupled Receptor HNFDS78 and their use as a therapeutic to treat disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding G-protein coupled receptors and for detecting altered levels of the polypeptide in a host.
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: September 11, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Bergsma, Nabil Elshourbagy, Henry Sarau, Steven Ruben