Patents by Inventor Nabil Dib

Nabil Dib has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170340865
    Abstract: An elongated, tubular-shaped balloon for a balloon catheter includes three regions along its length, in sequence: a proximal region, an intermediate region, and a distal region. The intermediate region is defined by a curved outer surface that is established by a radius of curvature r1. Similarly, a curved inner surface for the intermediate region is established by a radius of curvature r2, wherein r1?r2. Balloon thickness at the center of the intermediate region is tc, while balloon thickness in both the proximal and distal regions is t (t>tc). The stretchability and bendability of the balloon material is directly proportional to the thickness of the balloon, to thereby shape the balloon as a prolate spheroid when inflated.
    Type: Application
    Filed: August 26, 2016
    Publication date: November 30, 2017
    Inventors: Nabil Dib, Alan Iranian
  • Publication number: 20170043138
    Abstract: An elongated, tubular-shaped balloon for a balloon catheter includes three regions along its length, in sequence: a proximal region, an intermediate region, and a distal region. The intermediate region is defined by a curved outer surface that is established by a radius of curvature r1. Similarly, a curved inner surface for the intermediate region is established by a radius of curvature r2, wherein r1?r2. Balloon thickness at the center of the intermediate region is tc, while balloon thickness in both the proximal and distal regions is t (t>tc). The stretchability and bendability of the balloon material is directly proportional to the thickness of the balloon, to thereby shape the balloon as a prolate spheroid when inflated.
    Type: Application
    Filed: August 26, 2016
    Publication date: February 16, 2017
    Inventors: Nabil Dib, Alan Iranian
  • Publication number: 20150250988
    Abstract: A balloon system is disclosed for positioning a distal end of a catheter at a treatment site. The system includes an elongated catheter shaft that is formed with a lumen and a tubular shaped balloon membrane that is made of a compliant material. For the system, the proximal and distal ends of the balloon membrane are affixed to an outer surface of the shaft to establish an inflation chamber between the balloon membrane and the outer surface of the shaft. The balloon membrane can have a non-uniform thickness between the proximal and distal ends of the membrane to establish a selected membrane shape when the balloon is inflated. For example, the selected membrane shape can be a prolate spheroid. With this arrangement, a relatively short and a relatively flat inter-contact surface in the midway region of the membrane is obtained when the balloon is inflated.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 10, 2015
    Applicant: Translational Biologic Infusion Catheter, LLC
    Inventors: Nabil Dib, Alan Iranian
  • Patent number: 8798721
    Abstract: A system for advancing a needle through a vasculature to an injection site at the heart of a patient includes a guide catheter with a reflective distal tip. Also included is an imaging unit that is mounted on the catheter to radiate an energy field. Structurally, a distal portion of the catheter is biased to bend into a predetermined configuration that will position the distal end of the catheter for interception by the energy field. If necessary, coincidence of the reflective tip with the energy field is established by moving the energy field along the length of the guide catheter. With coincidence, the reflective tip reflects a signal that is useful for advancement of the needle from the guide catheter and into the injection site.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: August 5, 2014
    Assignee: Dib Ultrasound Catheter, LLC
    Inventor: Nabil Dib
  • Patent number: 8790298
    Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A recollection chamber in fluid communication with the separator allows for reconsolidation of the fluid after leaving the separator and for minimizing the damage caused to the vessel when the fluid exits the catheter. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid and increase retention of particles in targeted tissue.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: July 29, 2014
    Assignee: Translational Biologic Infusion Catheter, LLC
    Inventor: Nabil Dib
  • Publication number: 20140207107
    Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 24, 2014
    Applicant: Translational Biologic Infusion Catheter, LLC
    Inventors: Nabil Dib, Robert Edward Kohler
  • Publication number: 20140114239
    Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter to reduce particle flocculation. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid. A reinforcing member is employed to strengthen the catheter wall under the inflatable balloon. With this arrangement, the catheter does not kink or collapse due to the pressure exerted on the catheter wall when the balloon is inflated. In one embodiment, the reinforcing member includes an annular shaped ring. In another embodiment, the separator is positioned under the balloon and acts as the reinforcing member.
    Type: Application
    Filed: December 31, 2013
    Publication date: April 24, 2014
    Applicant: Translational Biologic Infusion Catheter, LLC
    Inventors: Nabil Dib, Robert Edward Kohler
  • Patent number: 8647311
    Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal tip. The tip is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A valve, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: February 11, 2014
    Assignee: Translational Biologic Infusion Catheter, LLC
    Inventor: Nabil Dib
  • Publication number: 20130102890
    Abstract: A system for advancing a needle through a vasculature to an injection site at the heart of a patient includes a guide catheter with a reflective distal tip. Also included is an imaging unit that is mounted on the catheter to radiate an energy field. Structurally, a distal portion of the catheter is biased to bend into a predetermined configuration that will position the distal end of the catheter for interception by the energy field. If necessary, coincidence of the reflective tip with the energy field is established by moving the energy field along the length of the guide catheter. With coincidence, the reflective tip reflects a signal that is useful for advancement of the needle 34b from the guide catheter and into the injection site.
    Type: Application
    Filed: November 30, 2012
    Publication date: April 25, 2013
    Inventor: Nabil Dib
  • Publication number: 20120226225
    Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A recollection chamber in fluid communication with the separator allows for reconsolidation of the fluid after leaving the separator and for minimizing the damage caused to the vessel when the fluid exits the catheter. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid and increase retention of particles in targeted tissue.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Inventor: Nabil Dib
  • Publication number: 20110295106
    Abstract: A system for advancing a needle through a vasculature to an injection site at the heart of a patient includes a guide catheter with a reflective distal tip. Also included is an imaging unit that is mounted on the catheter to radiate an energy field. Structurally, a distal portion of the catheter is biased to bend into a predetermined configuration that will position the distal end of the catheter for interception by the energy field. If necessary, coincidence of the reflective tip with the energy field is established by moving the energy field along the length of the guide catheter. With coincidence, the reflective tip reflects a signal that is useful for advancement of the needle from the guide catheter and into the injection site.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 1, 2011
    Inventor: Nabil Dib
  • Publication number: 20110087088
    Abstract: Computer-assisted processes are disclosed for using nuclear medicine image studies (e.g. PET or SPECT), preferably in combination with anatomic image studies (e.g., CT or MRI), to identify and quantify regions of affected organ tissue (e.g., myocardial infarcts), and to calculate doses of stem cells or other therapy to deliver to such regions. The resulting (static) image data showing the affected tissue may also be integrated with live (moving) image data, such as a fluoroscopy image, during a subsequent interventional procedure to generate a hybrid image showing the real time location of an injection catheter relative to the affected tissue.
    Type: Application
    Filed: November 6, 2009
    Publication date: April 14, 2011
    Applicant: CELL GENETICS, LLC
    Inventors: Ronald L. Korn, Mark D. Nathan, Nabil Dib
  • Publication number: 20110087110
    Abstract: Medical imaging processes are disclosed for facilitating the catheter-based delivery of stem cells or other therapy to affected organ tissue, including myocardial infarct and peri-infarct tissue. The disclosed processes include the integration of static image data showing the affected tissue with a live/moving image (e.g., a fluoroscopy image) to generate a hybrid view showing the real time location of an injection catheter relative to the affected tissue. The static image data may include or be derived from one or more noninvasive nuclear medicine imaging scans (e.g., PET or SPECT) generated prior to the catheterization procedure. The live image may also be augmented with visual markers showing target and/or actual injection locations. Also disclosed are methods for calculating amounts of therapy to deliver to the affected tissue.
    Type: Application
    Filed: November 6, 2009
    Publication date: April 14, 2011
    Applicant: CELL GENETICS, LLC
    Inventors: Mark D. Nathan, Ronald L. Korn, Nabil Dib
  • Publication number: 20110071496
    Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal tip. The tip is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A valve, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid.
    Type: Application
    Filed: September 21, 2009
    Publication date: March 24, 2011
    Inventor: Nabil Dib
  • Publication number: 20080125725
    Abstract: The invention is a medical device for containing and/or dispensing a therapeutic agent or a placebo to a patient. The medical device is preferably a syringe or an intravenous (IV) infusion system. A device according to the invention has a viewing portion through which a therapeutic agent or placebo contained therein may be seen by a patient or operator. The viewing portion is colored so that a therapeutic agent having a first color and a placebo having a second color that is different from the second color are virtually or entirely indistinguishable when contained within the device and viewed through the viewing portion.
    Type: Application
    Filed: August 4, 2006
    Publication date: May 29, 2008
    Inventor: Nabil Dib
  • Publication number: 20070060838
    Abstract: A medical device includes a needle and optionally a catheter and a sheath. The device takes a biopsy from a body tissue and/or injects a substance into a body tissue, such as heart tissue. One or more ports are located on the needle to either take a biopsy and/or inject a substance. If a catheter is included as part of the device, a relative motion restrictor may be included to restrict relative movement during needle deployment between the catheter and the sheath. Additionally, a driver may be employed to deploy the needle with one or more of a predefined force, acceleration and velocity to assist in needle penetration.
    Type: Application
    Filed: October 24, 2005
    Publication date: March 15, 2007
    Inventor: Nabil Dib
  • Publication number: 20050222518
    Abstract: Medical devices are delineated that may include a needle, a catheter and a sheath. Such devices may be used to take a biopsy from a patient and/or inject fluid into a patient, particularly in the patient's heart tissue. One or more ports may be located between the ends of the needle to facilitate the desired medical procedure. A relative motion restrictor may be included to restrict relative movement during needle deployment between the catheter and the sheath. Additionally, a driver may be employed to deploy the needle with one or more of a predefined force, acceleration and velocity to ease needle penetration.
    Type: Application
    Filed: April 6, 2004
    Publication date: October 6, 2005
    Inventor: Nabil Dib