Patents by Inventor Nabil Dib
Nabil Dib has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220409195Abstract: A handle apparatus comprising detachable hardware and void regions or attachment devices that accommodate the shape of surgical devices and imaging units such that the device is held securely and mechanically fixed to the imaging unit within the handle assembly.Type: ApplicationFiled: June 17, 2022Publication date: December 29, 2022Inventor: Nabil Dib
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Publication number: 20210298785Abstract: A handle apparatus comprising void regions or attachment devices that accommodate the shape of surgical devices and imaging units such that the device is held securely and mechanically fixed to the imaging unit within the handle assembly.Type: ApplicationFiled: December 31, 2020Publication date: September 30, 2021Inventors: Nabil Dib, Brad Knight, Charmaine Sutton, Michael Nagel, Lowry Barfield
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Publication number: 20210031002Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.Type: ApplicationFiled: October 19, 2020Publication date: February 4, 2021Inventors: Nabil Dib, Robert Edward Kohler
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Patent number: 10806891Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.Type: GrantFiled: October 30, 2018Date of Patent: October 20, 2020Assignee: Cook Regentec LLCInventors: Nabil Dib, Robert Edward Kohler
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Publication number: 20190060611Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.Type: ApplicationFiled: October 30, 2018Publication date: February 28, 2019Inventors: Nabil Dib, Robert Edward Kohler
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Patent number: 10155099Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.Type: GrantFiled: March 6, 2014Date of Patent: December 18, 2018Assignee: Cook Regentec LLCInventors: Nabil Dib, Robert Edward Kohler
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Patent number: 10058675Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter to reduce particle flocculation. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid. A reinforcing member is employed to strengthen the catheter wall under the inflatable balloon. With this arrangement, the catheter does not kink or collapse due to the pressure exerted on the catheter wall when the balloon is inflated. In one embodiment, the reinforcing member includes an annular shaped ring. In another embodiment, the separator is positioned under the balloon and acts as the reinforcing member.Type: GrantFiled: December 31, 2013Date of Patent: August 28, 2018Assignee: Cook Regentec LLCInventors: Nabil Dib, Robert Edward Kohler
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Publication number: 20170340865Abstract: An elongated, tubular-shaped balloon for a balloon catheter includes three regions along its length, in sequence: a proximal region, an intermediate region, and a distal region. The intermediate region is defined by a curved outer surface that is established by a radius of curvature r1. Similarly, a curved inner surface for the intermediate region is established by a radius of curvature r2, wherein r1?r2. Balloon thickness at the center of the intermediate region is tc, while balloon thickness in both the proximal and distal regions is t (t>tc). The stretchability and bendability of the balloon material is directly proportional to the thickness of the balloon, to thereby shape the balloon as a prolate spheroid when inflated.Type: ApplicationFiled: August 26, 2016Publication date: November 30, 2017Inventors: Nabil Dib, Alan Iranian
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Publication number: 20170043138Abstract: An elongated, tubular-shaped balloon for a balloon catheter includes three regions along its length, in sequence: a proximal region, an intermediate region, and a distal region. The intermediate region is defined by a curved outer surface that is established by a radius of curvature r1. Similarly, a curved inner surface for the intermediate region is established by a radius of curvature r2, wherein r1?r2. Balloon thickness at the center of the intermediate region is tc, while balloon thickness in both the proximal and distal regions is t (t>tc). The stretchability and bendability of the balloon material is directly proportional to the thickness of the balloon, to thereby shape the balloon as a prolate spheroid when inflated.Type: ApplicationFiled: August 26, 2016Publication date: February 16, 2017Inventors: Nabil Dib, Alan Iranian
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Publication number: 20150250988Abstract: A balloon system is disclosed for positioning a distal end of a catheter at a treatment site. The system includes an elongated catheter shaft that is formed with a lumen and a tubular shaped balloon membrane that is made of a compliant material. For the system, the proximal and distal ends of the balloon membrane are affixed to an outer surface of the shaft to establish an inflation chamber between the balloon membrane and the outer surface of the shaft. The balloon membrane can have a non-uniform thickness between the proximal and distal ends of the membrane to establish a selected membrane shape when the balloon is inflated. For example, the selected membrane shape can be a prolate spheroid. With this arrangement, a relatively short and a relatively flat inter-contact surface in the midway region of the membrane is obtained when the balloon is inflated.Type: ApplicationFiled: March 7, 2014Publication date: September 10, 2015Applicant: Translational Biologic Infusion Catheter, LLCInventors: Nabil Dib, Alan Iranian
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Patent number: 8798721Abstract: A system for advancing a needle through a vasculature to an injection site at the heart of a patient includes a guide catheter with a reflective distal tip. Also included is an imaging unit that is mounted on the catheter to radiate an energy field. Structurally, a distal portion of the catheter is biased to bend into a predetermined configuration that will position the distal end of the catheter for interception by the energy field. If necessary, coincidence of the reflective tip with the energy field is established by moving the energy field along the length of the guide catheter. With coincidence, the reflective tip reflects a signal that is useful for advancement of the needle from the guide catheter and into the injection site.Type: GrantFiled: May 26, 2010Date of Patent: August 5, 2014Assignee: Dib Ultrasound Catheter, LLCInventor: Nabil Dib
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Patent number: 8790298Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A recollection chamber in fluid communication with the separator allows for reconsolidation of the fluid after leaving the separator and for minimizing the damage caused to the vessel when the fluid exits the catheter. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid and increase retention of particles in targeted tissue.Type: GrantFiled: May 17, 2012Date of Patent: July 29, 2014Assignee: Translational Biologic Infusion Catheter, LLCInventor: Nabil Dib
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Publication number: 20140207107Abstract: A method for infusing a liquid into a patient's vasculature in accordance with an infusion protocol is disclosed. For this method, an infusion catheter having a multi-lumen infusion unit that is mounted adjacent the catheter's distal end is positioned in an artery within a predetermined distance from an intended target tissue surface. An inflation balloon is then deployed to at least partially occlude the artery and a force is exerted on the liquid to establish a flow rate for the liquid in the catheter. Specifically, the force is exerted to infuse the liquid from the catheter through the infusion unit and into the vasculature with a homogeneous distribution of the liquid to cover the intended surface of the target tissue. The flow rate can be established in accordance with an infusion protocol that is characterized by time and liquid volume parameters based on viscosity and pressure values in the liquid.Type: ApplicationFiled: March 6, 2014Publication date: July 24, 2014Applicant: Translational Biologic Infusion Catheter, LLCInventors: Nabil Dib, Robert Edward Kohler
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Publication number: 20140114239Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter to reduce particle flocculation. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid. A reinforcing member is employed to strengthen the catheter wall under the inflatable balloon. With this arrangement, the catheter does not kink or collapse due to the pressure exerted on the catheter wall when the balloon is inflated. In one embodiment, the reinforcing member includes an annular shaped ring. In another embodiment, the separator is positioned under the balloon and acts as the reinforcing member.Type: ApplicationFiled: December 31, 2013Publication date: April 24, 2014Applicant: Translational Biologic Infusion Catheter, LLCInventors: Nabil Dib, Robert Edward Kohler
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Patent number: 8647311Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal tip. The tip is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A valve, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid.Type: GrantFiled: September 21, 2009Date of Patent: February 11, 2014Assignee: Translational Biologic Infusion Catheter, LLCInventor: Nabil Dib
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Publication number: 20130102890Abstract: A system for advancing a needle through a vasculature to an injection site at the heart of a patient includes a guide catheter with a reflective distal tip. Also included is an imaging unit that is mounted on the catheter to radiate an energy field. Structurally, a distal portion of the catheter is biased to bend into a predetermined configuration that will position the distal end of the catheter for interception by the energy field. If necessary, coincidence of the reflective tip with the energy field is established by moving the energy field along the length of the guide catheter. With coincidence, the reflective tip reflects a signal that is useful for advancement of the needle 34b from the guide catheter and into the injection site.Type: ApplicationFiled: November 30, 2012Publication date: April 25, 2013Inventor: Nabil Dib
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Publication number: 20120226225Abstract: A system for moving particles suspended in a first fluid, and for infusing them into the stream of a second fluid, includes a catheter with a multi-lumen distal separator. The separator is formed with a plurality of parallel lumens, wherein each lumen has a predetermined diameter. Importantly, the diameter of each lumen is dimensioned to sequentially receive particles therethrough, to prevent the particles from flocculating before they enter the stream of the second fluid. A recollection chamber in fluid communication with the separator allows for reconsolidation of the fluid after leaving the separator and for minimizing the damage caused to the vessel when the fluid exits the catheter. An inflatable balloon, affixed to the outside of the catheter, can be provided to regulate flow of the second fluid and thereby facilitate entry of the particles into the stream of the second fluid and increase retention of particles in targeted tissue.Type: ApplicationFiled: May 17, 2012Publication date: September 6, 2012Inventor: Nabil Dib
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Publication number: 20110295106Abstract: A system for advancing a needle through a vasculature to an injection site at the heart of a patient includes a guide catheter with a reflective distal tip. Also included is an imaging unit that is mounted on the catheter to radiate an energy field. Structurally, a distal portion of the catheter is biased to bend into a predetermined configuration that will position the distal end of the catheter for interception by the energy field. If necessary, coincidence of the reflective tip with the energy field is established by moving the energy field along the length of the guide catheter. With coincidence, the reflective tip reflects a signal that is useful for advancement of the needle from the guide catheter and into the injection site.Type: ApplicationFiled: May 26, 2010Publication date: December 1, 2011Inventor: Nabil Dib
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Publication number: 20110087088Abstract: Computer-assisted processes are disclosed for using nuclear medicine image studies (e.g. PET or SPECT), preferably in combination with anatomic image studies (e.g., CT or MRI), to identify and quantify regions of affected organ tissue (e.g., myocardial infarcts), and to calculate doses of stem cells or other therapy to deliver to such regions. The resulting (static) image data showing the affected tissue may also be integrated with live (moving) image data, such as a fluoroscopy image, during a subsequent interventional procedure to generate a hybrid image showing the real time location of an injection catheter relative to the affected tissue.Type: ApplicationFiled: November 6, 2009Publication date: April 14, 2011Applicant: CELL GENETICS, LLCInventors: Ronald L. Korn, Mark D. Nathan, Nabil Dib
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Publication number: 20110087110Abstract: Medical imaging processes are disclosed for facilitating the catheter-based delivery of stem cells or other therapy to affected organ tissue, including myocardial infarct and peri-infarct tissue. The disclosed processes include the integration of static image data showing the affected tissue with a live/moving image (e.g., a fluoroscopy image) to generate a hybrid view showing the real time location of an injection catheter relative to the affected tissue. The static image data may include or be derived from one or more noninvasive nuclear medicine imaging scans (e.g., PET or SPECT) generated prior to the catheterization procedure. The live image may also be augmented with visual markers showing target and/or actual injection locations. Also disclosed are methods for calculating amounts of therapy to deliver to the affected tissue.Type: ApplicationFiled: November 6, 2009Publication date: April 14, 2011Applicant: CELL GENETICS, LLCInventors: Mark D. Nathan, Ronald L. Korn, Nabil Dib