Publication number: 20050171140
Abstract: Compounds are provided having the following structure and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, U, V, W, Y, and n are as defined above, which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy. A method for treating the above diseases employing the above compounds is also provided.
Type:
Application
Filed:
November 15, 2004
Publication date:
August 4, 2005
Inventors:
Stephen O'Connor, Jeffrey Robl, Saleem Ahmad, Sharon Bisaha, Natesan Murugesan, Khehyong Ngu, Yan Shi, Philip Stein, Nachimuthu Soundararajan, Kenneth Natalie, Laxma Kolla, Justin Sausker, Sandra Quinlan, Junying Fan, Dejah Petsch, Zhenrong Guo