Abstract: System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time

Abstract: The present invention relates to a method for predicting neurodegenerative decline and/or its severity for a patient, especially of cognitive impairment (CI). Strokes and Parkinson's disease are frequently associated with occurrence of long-term cognitive impairment or dementia with still incompletely resolved mechanisms. The discovery of diagnostic and predictive biomarkers thus remains a major challenge. The method of the invention uses radiomics corresponding to texture features extracted from a plurality of previously-acquired medical brain images and correlated with previously-acquired clinical and/or biological data. A classifier is trained beforehand for learning these radiomics, and then operated on radiomics computed from at least one brain image of a patient to generate a score representative of its risks of neurodegenerative decline. By applying this method on a cohort of 160 MCI and non-MCI patients, the inventors show that MCI patients could be early predicted with a mean accuracy of 88%.

Abstract: System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time

Abstract: The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

Abstract: An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the ?X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the ?X and ?Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.

Abstract: A method (200) for planning of a treatment with photodynamic therapy for a patient includes performing a measurement (230) of the volume of the treatment area by volume reconstruction from digital processing of contours inputted directly into a series of digital images of the area being treated, then determining (250) by calculating the number of optical fibers used, their position relative to the brachytherapy grid and their insertion length which optimizes the correspondence of a total theoretical action volume calculated with the measured volume of the treatment area. The total theoretical action volume is calculated based on the position of each fiber, and an elementary theoretical action volume of a fiber corresponding to the volume of a cylinder with predetermined action radius R, and height corresponding to the insertion length of the fiber.

Abstract: An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the ?X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the ?X and ?Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.

Abstract: System for treatment by photodynamic therapy comprising: —an illuminating device (10) including a light emitting surface for illuminating an internal surface to be treated with a light adapted to activate a photosensitizer compound, the light emitting surface emitting light with a distribution of light power comprising fractions of light power decreasing from a maximum at the light emitting surface, the light emitting surface having a determined illumination profile that provides respective illuminated areas for a plurality of the fractions of light power, —a positioning system (40) adapted to position in real-time the light emitting surface within a reference frame, —an electronic unit (45) connected to the positioning system (40) and adapted to monitor in real-time a dose of light energy delivered to the internal surface based on the illumination profile and the position of the light emitting surface.

Abstract: The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

Abstract: Prostate phantom comprising an artificial prostate (1) and an artificial lesion arranged within the artificial prostate (1), wherein the artificial prostate (1) comprises: a first part (1a) mimicking a peripheral zone of a zonal anatomy of the prostate, the first part (1a) being made of a first artificial tissue and comprising a closed outer surface, at least a second part (1b) separate from the first part (1a) and mimicking at least a second zone of the zonal anatomy of the prostate, the second part (1b) being made of a second artificial tissue and comprising a closed outer surface, the first (1a) and second (1b) parts contacting each other along an interface mimicking a boundary between the peripheral zone and the second zone.

Abstract: Prostate phantom comprising an artificial prostate (1) and an artificial lesion arranged within the artificial prostate (1), wherein the artificial prostate (1) comprises: a first part (1a) mimicking a peripheral zone of a zonal anatomy of the prostate, the first part (1a) being made of a first artificial tissue and comprising a closed outer surface, at least a second part (1b) separate from the first part (1a) and mimicking at least a second zone of the zonal anatomy of the prostate, the second part (1b) being made of a second artificial tissue and comprising a closed outer surface, the first (1a) and second (1b) parts contacting each other along an interface mimicking a boundary between the peripheral zone and the second zone.

Abstract: Calibration phantom and method for measuring and correcting geometric distortions in an image of a body part of a patient Calibration phantom (5) for a medical imaging system, comprising a plurality of separate detection elements (20) arranged in a determined pattern, each detection element (20) containing a product that is visible by the medical imaging system.

Abstract: A method (200) for planning of a treatment with photodynamic therapy for a patient includes performing a measurement (230) of the volume of the treatment area by volume reconstruction from digital processing of contours inputted directly into a series of digital images of the area being treated, then determining (250) by calculating the number of optical fibers used, their position relative to the brachytherapy grid and their insertion length which optimizes the correspondence of a total theoretical action volume calculated with the measured volume of the treatment area. The total theoretical action volume is calculated based on the position of each fiber, and an elementary theoretical action volume of a fiber corresponding to the volume of a cylinder with predetermined action radius R, and height corresponding to the insertion length of the fiber.

Abstract: Calibration phantom and method for measuring and correcting geometric distortions in an image of a body part of a patient Calibration phantom (5) for a medical imaging system, comprising a plurality of separate detection elements (20) arranged in a determined pattern, each detection element (20) containing a product that is visible by the medical imaging system.