Abstract: A drug delivery device includes a magnet assembly, a coil assembly and processing circuitry. The magnet assembly has a plurality of magnets arranged in a ring. The coil assembly has one or more coils. The magnet assembly and the coil assembly are arranged to rotate relative to each other during ejection of medicament from the drug delivery device such that a voltage signal is produced in the coil assembly when a unit of dose is ejected. The processing circuitry is arranged to: receive the voltage signal; increment a counter in response to receipt of the voltage signal; and store information indicative of the number of units of dose ejected during a medicament ejection.

Abstract: In one example in accordance with the present disclosure, a method for threat score determination includes detecting a change in malicious activity for a security object. The method also includes identifying an indicator that provides contextual information for the security object and determining a linked resource that is associated with a database record of the security object. The method also includes determining a first threat score associated with the security object and determining a relationship between the linked resource and the security object. The method also includes determining a second threat score associated with the linked resource based on the indicator, the threat score of the linked object and the relationship between the linked resource and the security object.

Abstract: An automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product. The drug container includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the insertion needle. The automatic injection device further has a drive system configured to cause linear movement of the plunger to force the pharmaceutical product into the fluid path. The drive system has a driving element and a movable element. The automatic injection device additionally has electronics configured to provide a signal to the drive system to move the plunger. The movable element has an outer magnet at least partially surrounding the drug container and an inner magnet inside the drug container.

Abstract: Examples disclosed herein relate to source entities of security indicators. Some examples disclosed herein enable identifying, in a security information sharing platform, a security indicator that is originated from a source entity where the security indicator comprises an observable. Some examples further enable determining a reliability level of the source entity based on at least one of: security events, sightings of the observable, a first set of user feedback information that is submitted for the security indicator by users of the security information sharing platform, or a second set of user feedback information that is collected from external resources that are external to the security information sharing platform.

Abstract: An automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product. The drug container includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the insertion needle. The automatic injection device further has a drive system configured to cause linear movement of the plunger to force the pharmaceutical product into the fluid path. The drive system has a driving element and a movable element. The automatic injection device additionally has electronics configured to provide a signal to the drive system to move the plunger. The movable element has an outer magnet at least partially surrounding the drug container and an inner magnet inside the drug container.

Abstract: A control system for automatic operation of a coker, the control system. The control system includes a drum feeder operable to modulate a feed of oil into a coke drum of the coker. The control system further includes a controller with a processing circuit. The processing circuit obtains a target coke rate indicating a target rate at which to accumulate coke within the coke drum. The processing circuit further uses a neural network model to generate a target coker feed rate predicted to result in the coke accumulating within the coke drum at the target coke rate. The target coker feed rate indicates a target rate at which to feed the oil into the coke drum. The processing circuit further operates the drum feeder using the target coker feed rate to modulate the feed of oil into the coke drum.

Abstract: Examples disclosed herein relate to associations among data records in a security information sharing platform. Some examples may enable creating, in the security information sharing platform that enables sharing of security information among a plurality of users, an association between a first security indicator comprising a first observable and a first data record based on sightings of the first observable by at least one source entity associated with the first data record. Some examples may further enable obtaining a search query that specifies the first security indicator, and identifying a set of data records that satisfy the search query. The set of data records may include the first data record.

Abstract: The present invention provides compositions and methods for improved T-cell therapy of cancer characterized by overexpression of Her2/neu oncogene. Provided are T cells capable of expressing or expressing chimeric antigen receptor (CAR) that specifically recognizes Her2/neu. These T cells have prolonged half-life in the blood circulation and enhanced cytotoxicity, and are used in treatment of a cancer characterized by overexpression of Her2/neu oncogene.

Abstract: A system comprising a device and a monitoring unit configured to monitor the mechanical health of the device is disclosed. The monitoring unit may comprise at least one actuator, at least one sensor and at least one processing resource. The at least one actuator may be configured to vibrate the device and the at least one sensor may be configured to detect a corresponding output of the device. The at least one processing resource may be configured to process the output detected by the at least one sensor and to assess the mechanical health of the device by comparing the detected output of the device to a healthy fingerprint of the device, wherein the healthy fingerprint is an output of the particular device being tested when it is free of mechanical defects.

Abstract: Examples disclosed herein relate to sharing of community-based security information. Some examples may enable generating a first community on a security information sharing platform that enables sharing of security information among a plurality of communities; obtaining a first security indicator from a first user of the first community; providing the first security indicator to the first community; obtaining contextual information related to the first security indicator from a second user of the first community; including the first security indicator and the contextual information related to the first security indicator in the security information of the first community; and encrypting a portion of the security information of the first community with an encryption key, wherein the encryption key is unavailable to users outside of the first community.

Abstract: Examples disclosed herein relate to alerts for communities of a security information sharing platform. Some examples may enable obtaining a security indicator from a user of a first community of a security information sharing platform that enables sharing of security information among a plurality of communities; including the security indicator in community-based security information associated with the first community, the first security indicator comprising a first observable; sharing the first security indicator with the security information sharing platform; obtaining, from the security information sharing platform, information related to sightings of the first observable; and providing a first alert to the first community based on the information related to the sightings of the first observable.

Abstract: An automatic injection device has an insertion needle configured to be inserted into a patient and a drug container which contains a pharmaceutical product and includes a plunger. The automatic injection device also has a fluid path which fluidly connects the drug container to the insertion needle, and a drive system configured to cause linear movement of the plunger to force the pharmaceutical product into the fluid path. The passive drive system has a movable element. The movable element has a shape memory alloy and is configured to change shape to move the plunger.

Abstract: A system and method for calibrating an IV pump infusion system tube comprises a fluid source, an infusion system comprising, an IV pump, a drive unit, a chamber with known constant volume, a control unit, and IV tubing with a known inner diameter tolerance, and a set of conductive plates. The system administers medicinal fluid, calculates the flow rate of the medicinal fluid in the chamber by measuring the time the capacitance level of the medicinal fluid changes from a capacitance level corresponding to a first (initial) position to a capacitance level corresponding to a second (filled) position, compares the calculated flow rate with a set flow rate of the IV pump input in the control unit prior to infusion, and adjusts the IV pump and flow rate based on the compared deviations for more accurate delivery to a patient. This configuration may therefore provide a more precise delivery rate.

Abstract: A system and method for calibrating an IV pump infusion system tube comprises a fluid source, an infusion system comprising, an IV pump, a drive unit, a chamber with known constant volume, a control unit, and IV tubing with a known inner diameter tolerance, and a sensor and floating detection object. The system administers medicinal fluid, calculates the flow rate of the medicinal fluid in the chamber by measuring the time the floating detection object and medicinal fluid rises in the chamber, compares the calculated flow rate with a set flow rate of the IV pump input in the control unit prior to infusion, and adjusts the IV pump and flow rate based on the compared deviations for more accurate delivery to a patient. This configuration may provide a more precise delivery rate of medicinal fluid, preventing harm to the patient and waste of medicine.

Abstract: A system and method for calibrating an IV pump infusion system tube comprises a fluid source, an infusion system comprising, an IV pump, a drive unit, a chamber with known constant volume, a control unit, and IV tubing with a known inner diameter tolerance, and a switch and magnetic floating object. The system administers medicinal fluid, calculates the flow rate of the medicinal fluid in the chamber by measuring the time the switch is activated as medicinal fluid rises in the chamber, compares the calculated flow rate with a set flow rate of the IV pump input in the control unit prior to infusion, and adjusts the IV pump and flow rate based on the compared deviations for more accurate delivery to a patient. This configuration may provide a more precise delivery rate of medicinal fluid, preventing harm to the patient and waste of medicine.

Abstract: An apparatus and method for the aseptic delivery of a solution in a wearable form factor is disclosed. A patch pump may include a start button that, upon activation, causes an elastic fluid path to move. The elastic fluid path may include a first end that moves along a first plane to penetrate a solution container as well as a second end that moves, concurrently, along a second plane to penetrate a user's tissue. The elastic fluid path may maintain its flow resistance during the concurrent movement. The patch pump's housing may include a door with an opening configured to enable the second end to penetrate a user via the opening. The door may open when the device is removed from the user such that a portion of the open door may extend further than the second end of the elastic fluid path to prevent exposure of the second end.

Abstract: A device and method are disclosed for an elastic strip with a first fixed end and a second movable end, the elastic strip configured to be in at least one of a tense state and an elastic state. A release mechanism is configured to maintain the elastic strip in a tense state when the release mechanism is in a holding state, and configured to release the elastic strip when in a release state. A needle path with a first bend is provided. A rigid needle is configured to traverse a first portion of the needle path when the elastic strip is in the elastic state and a cannula is located in the needle path and configured to traverse a second portion of the needle path when the rigid needle traverses the first portion of the needle path.

Abstract: A device and method for cannula insertion into a users tissue are disclosed. A patch pump comprising a non-linear needle path with a first bend may be provided. A rigid needle may be located in the needle path and may be composed of a material that allows the rigid needle to maintain a bend at the first bend when traversing the non-linear needle path. A movement mechanism may be configured to apply force on a first end of the rigid needle to cause the rigid needle to traverse the non-linear needle path from a first needle position to a second needle position. A cannula may receive a force from a second end of the rigid needle when the movement mechanism applies the force on the first end of the rigid needle and configured to traverse from a first cannula position to a second cannula position based on the force.

Abstract: A method of generating a controller for a continuous process. The method includes receiving from a storage memory, off-line stored values of one or more controlled variables and one or more manipulated variables of the continuous process over a plurality of time points. The off-line stored values are used to train a first neural network to operate as a predictor of the controlled variables. Then, the method includes training a second neural network to operate as a controller of the continuous process using the first neural network after it was trained to operate as the predictor for the continuous process and employing the second neural network as a controller of the continuous process.

Abstract: Examples disclosed herein relate to visualization of associations among data records in a security information sharing platform. Some examples may enable creating, in the security information sharing platform, an association between a first data record comprising a security indicator, and a second data record. Some examples may further enable providing a visual representation of the first data record, the second data record, and the association, wherein the first data record represents a first node in the visual representation, the second data record represents a second node in the visual representation, and the association represents an edge that connects the first node and the second node.