Patents by Inventor Nadine Defranoux

Nadine Defranoux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for computer modeling a joint
    Patent number: 7472050
    Abstract: The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: December 30, 2008
    Assignee: Entelos, Inc.
    Inventors: Nadine A. Defranoux, Todd B. Dubnicoff, David J. Klinke, II, Annette K. Lewis, Thomas S. Paterson, Saroja Ramanujan, Lisl K. M. Shoda, Karl Petter Soderstrom, Herbert K. Struemper
  • Method and apparatus for computer modeling a joint
    Publication number: 20060058988
    Abstract: The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.
    Type: Application
    Filed: February 11, 2005
    Publication date: March 16, 2006
    Inventors: Nadine Defranoux, Todd Dubnicoff, David Klinke, Annette Lewis, Thomas Paterson, Saroja Ramanujan, Lisl Shoda, Karl Soderstrom, Herbert Struemper
  • Treatment of rheumatoid arthritis with FLIP antagonists
    Publication number: 20050208151
    Abstract: The invention encompasses novel methods of treating rheumatoid arthritis and its symptoms and novel methods of identifying and screening for drugs useful in the treatment of rheumatoid arthritis and its clinical symptoms. Targeted manipulation of a computer model of a human rheumatic joint provided the surprising result that decreasing the activity of FLIP, an inhibitor of apoptosis, by at least 25% has a significant impact on the pathophysiology of rheumatoid arthritis. Inhibition of the activity of FLIP by at least 25% is predicted to alleviate the symptoms of rheumatoid arthritis.
    Type: Application
    Filed: November 1, 2004
    Publication date: September 22, 2005
    Applicant: Entelos, Inc.
    Inventors: Vincent Hurez, Saroja Ramanujan, Lisl Shoda, Leif Wennerberg, Seth Michelson, Nadine Defranoux
  • Treatment of rheumatoid arthritis with hypoxia inducible factor-1alpha antagonists
    Publication number: 20050148496
    Abstract: The invention encompasses a novel method of treating inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases and their clinical symptoms. The inventors have made the discovery that the activity of HIF-1?, a transcription regulator known to have an effect on some cancers, has a significant impact on the pathophysiology of rheumatoid arthritis. The symptoms of an inflammatory disease, such as rheumatoid arthritis, may be alleviated by administering a compound that inhibits the activity of HIF-1?.
    Type: Application
    Filed: November 24, 2004
    Publication date: July 7, 2005
    Applicant: Entelos, Inc.
    Inventors: Nadine Defranoux, Vincent Hurez, Seth Michelson, Lisl Shoda, Leif Wennerberg
  • Method and apparatus for computer modeling a joint
    Patent number: 6862561
    Abstract: The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: March 1, 2005
    Assignee: Entelos, Inc.
    Inventors: Nadine A. Defranoux, Todd B. Dubnicoff, David J. Klinke, II, Annette K. Lewis, Thomas S. Paterson, Saroja Ramanujan, Lisl K. M. Shoda, Karl Petter Soderstrom, Herbert K. Struemper
  • Method and apparatus for computer modeling a joint
    Publication number: 20030078759
    Abstract: The present invention relates to a mathematical and computer model of a joint. The model includes representation of the biological processes related to the synovial tissue and cartilage. In one embodiment, the model represents a human joint afflicted with rheumatoid arthritis.
    Type: Application
    Filed: May 22, 2002
    Publication date: April 24, 2003
    Inventors: Nadine A. Defranoux, Todd B. Dubnicoff, David J. Klinke, Annette K. Lewis, Thomas S. Paterson, Saroja Ramanujan, Lisl K. M. Shoda, Karl Petter Soderstrom, Herbert K. Struemper