Patents by Inventor Nadine Kuhl

Nadine Kuhl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF BTK INHIBITOR AND INTERMEDIATES THEREOF
    Publication number: 20240262834
    Abstract: The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 26, 2022
    Publication date: August 8, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Yonggang Chen, James Corry, Richard Desmond, Michael J. Di Maso, Jacob H. Forstater, Jeffrey T. Kuethe, Nadine Kuhl, Reed Larson, Francois Levesque, Karthik Narsimhan, Douglas Otte, Christopher K. Prier, Michael Shevlin, Eric Sirota, Lushi Tan, David A. Thaisrivongs, Ben W. H. Turnbull, Zhixun Wang, Kaijiong Xiao
  • Processes for the preparation of sugammadex
    Patent number: 11634511
    Abstract: The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and disodium 3 -mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclod extrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-y-cyclodextrin from ?-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin comprising, inter alia, reacting ?-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: April 25, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Jamie M. McCabe Dunn, Nadine Kuhl, Wenyong Chen, Yang Cao, Donald R. Gauthier, Jr., Alan Michael Hyde, Susan L. Zultanski
  • PROCESSES FOR THE PREPARATION OF SUGAMMADEX
    Publication number: 20210206884
    Abstract: The present invention provides processes for the preparation of sugammadex: (I) In one aspect, there is provided a process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and 3-mercaptopropionic acid. In another aspect, there is provided an alternative process for the preparation of sugammadex from 8-per-deoxy-8-bromo-?-cyclodextrin and disodium 3-mercaptopropionate. In another aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin, which may be used in the production of sugammadex. In one such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin from ?-cyclodextrin and a brominating agent. In another such aspect, there is provided a process for the preparation of 8-per-deoxy-8-bromo-?-cyclodextrin comprising, inter alia, reacting ?-cyclodextrin with an electrophilic brominating agent, a deoxygenating agent, and an acid in the presence of an organic solvent.
    Type: Application
    Filed: June 3, 2019
    Publication date: July 8, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Jamie M. McCabe Dunn, Nadine Kuhl, Wenyong Chen, Yang Cao, Donald R. Gauthier, Jr., Alan Michael Hyde, Susan L. Zultanski