Abstract: Controlled-release tablets exhibiting excellent storage stability are achieved by granulating a pharmaceutically active agent with a hydroxyalkylcelluose, blending the resulting granules with an extragranular phase composed of a particulate material that provides a sustained-release matrix, and compressing the blend into a tablet form, which may be optionally coated, such as with an enteric coating composition, to provide delayed release and/or to enhance stability of the active agent.

Abstract: A multilayer oral dosage form that provides controlled release of an active compound includes a non-erodible core containing a pharmaceutically active compound and/or a nutritionally active compound, and at least one release-modulating layer laminated to each side of the core layer. The dosage form can be prepared using simple, inexpensive tablet compression techniques.

Abstract: A nutritional solid oral dosage form for administering a calcium nutrient with an iron nutrient includes enterically coated particles, granules or pellets containing a calcium nutrient. An iron nutrient is incorporated into an immediate release matrix. The coated calcium nutrient may be located in a core surrounded by the immediate release matrix or distributed in the immediate release matrix. The coating and matrix are formulated to allow immediate release of the iron nutrient in an upper part of the gastrointestinal tract and delayed release of the calcium nutrient until the remainder of the dosage forms reaches a higher pH region of the gastrointestinal tract.