Publication number: 20120035072
Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
Type:
Application
Filed:
August 26, 2011
Publication date:
February 9, 2012
Applicants:
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt (GmbH, Mayo Foundation for Medical Education and Research, Eberhard Karls Universitaet Tuebingen
Inventors:
Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra (Leitner) Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
Patent number: 8029986
Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
Type:
Grant
Filed:
September 27, 2005
Date of Patent:
October 4, 2011
Assignees:
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Eberhard Karls Universitaet Tuebingen, Mayo Foundation for Medical Education and Research
Inventors:
Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Johannes Gloeckner, Thomas Gasser, Petra Herzig, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti
Publication number: 20100235933
Abstract: The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
Type:
Application
Filed:
September 27, 2005
Publication date:
September 16, 2010
Applicants:
Mayo Clinic, GSF Forschungszentrum fuer umwelt und Gesundheit GmbH, Eberhard Karls Universitaet Tuebingen
Inventors:
Thomas Meitinger, Tim Matthias Strom, Saskia Biskup, Marius Ueffing, Elisabeth Kremmer, Christian Gloeckner, Thomas Gasser, Petra Leitner, Friedrich Asmus, Nadja Patenge, Alexander Zimprich, Matthew J. Farrer, Jennifer M. Kachergus, Sara J. Lincoln, Mary M. Hulihan, Zibigniew Wszolek, Ryan Uitti