Abstract: The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I)

Abstract: The present invention is directed to a sequence dependent polynucleotide nanomechanical device based on a nucleic acid paranemic crossover (PX) molecule which is a four-stranded structure related to parallel double crossover molecules, except that every possible crossover takes place. Eliminating two crossovers leads to a topoisomer, termed JX2, in which one pair of ends are switched (rotated 180°) while the other pair of ends remain the same. The device can be cycled between the two states, PX and JX2, by replacing single strands that set the state to be PX or JX2.

Abstract: The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I)

Abstract: Two dimensional polynucleic acid arrays are assembled from robust nucleic acid motifs as polygonal units. The polygonal units in an array have edges composed of nucleic acid multi-crossover domains and are joined together by double cohesion of adjacent polygonal units. A subset of polygonal units in the array have a nanoparticle or pendant molecule attached to an end of one edge of each polygonal unit within this subset.

Abstract: Robust nucleic acid arrays and lattices are assembled based on double crossover cohesion of polygonal units whose edges are composed of nucleic acid multi-crossover domains.

Abstract: A polynucleic acid nanomechanical device with a linear array of alternating PX-JX2 devices and nucleic acid multi-crossover motifs that facilitate the assembly of a nucleic acid strand and functions as an artificial ribosome by translating a nucleic acid signal into an unrelated nucleic acid sequence.

Abstract: A multiped, capable of traveling in more than one direction along a molecular path in a nano-robotic system where the steps taken by the feet of the multiped are controlled in a sequence specific fashion, is presented. The feet of the multiped dock to footholds on the molecular path via cohesion with “set” molecules and are released from the footholds through the introduction of “unset” molecules that detach or strip away the “set” molecules.

Abstract: The present invention is directed to a sequence dependent polynucleotide nanomechanical device based on a nucleic acid paranemic crossover (PX) molecule which is a four-stranded structure related to parallel double crossover molecules, except that every possible crossover takes place. Eliminating two crossovers leads to a topoisomer, termed JX2, in which one pair of ends are switched (rotated 180°) while the other pair of ends remain the same. The device can be cycled between the two states, PX and JX2, by replacing single strands that set the state to be PX or JX2.

Abstract: Two- and three-dimensional periodic lattices are constructed from repeating units of at least two antiparallel nucleic acid multi-crossover molecules. The repeating units range from single component to multi-component.

Abstract: Two and three dimensional polynucleic acid structures, such as periodic lattices, may be constructed from an ordered array of antiparallel double crossover molecules assembled from single stranded oligonucleotides or polynucleotides. These antiparallel double crossover molecules have the structural rigidity necessary to serve as building block components for two and three dimensional structures having the high translational symmetry associated with crystals.