Patents by Inventor Nael F. Osman
Nael F. Osman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240108229Abstract: Methods for providing MRI-derived strain measurements are described. Some methods include calculating a first set of strain measurements for each of a plurality of different segments of a heart over an entire single cardiac cycle from obtained MRI image data. Then, for each segment of the plurality of different segments, electronically identifying a peak train value and associated time point of the cardiac cycle in the first set of strain measurements; and electronically adjusting the first set of strain measurements at each time point of the cardiac cycle using the identified peak strain value as a reference peak strain value to thereby provide strain measurements that are adjusted relative to a defined time during the cardiac cycle irrespective of when signal acquisition of the obtained MRI image data was initiated during the cardiac cycle. Risk scores, contouring review, contraction pattern on a 3-D cardiac model are also disclosed.Type: ApplicationFiled: November 30, 2023Publication date: April 4, 2024Inventor: Nael F. Osman
-
Patent number: 11872019Abstract: Methods for providing MRI-derived strain measurements are described. Some methods include calculating a first set of strain measurements for each of a plurality of different segments of a heart over an entire single cardiac cycle from obtained MRI image data. Then, for each segment of the plurality of different segments, electronically identifying a peak train value and associated time point of the cardiac cycle in the first set of strain measurements; and electronically adjusting the first set of strain measurements at each time point of the cardiac cycle using the identified peak strain value as a reference peak strain value to thereby provide strain measurements that are adjusted relative to a defined time during the cardiac cycle irrespective of when signal acquisition of the obtained MRI image data was initiated during the cardiac cycle. Risk scores, contouring review, contraction pattern on a 3-D cardiac model are also disclosed.Type: GrantFiled: May 21, 2020Date of Patent: January 16, 2024Assignee: Myocardial Solutions, Inc.Inventor: Nael F. Osman
-
Publication number: 20210353171Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.Type: ApplicationFiled: July 28, 2021Publication date: November 18, 2021Inventor: Nael F. Osman
-
Patent number: 11103153Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.Type: GrantFiled: November 14, 2019Date of Patent: August 31, 2021Assignee: Myocardial Solutions, Inc.Inventor: Nael F. Osman
-
Publication number: 20200383584Abstract: Methods for deriving and/or adjusting MRI strain measurements are described. Some methods include calculating a first set of strain measurements for each of a plurality of different segments of a heart over an entire single cardiac cycle from obtained MRI image data. Then, for each segment of the plurality of different segments, electronically identifying a peak train value and associated time point of the cardiac cycle in the first set of strain measurements; and electronically adjusting the first set of strain measurements at each time point of the cardiac cycle using the identified peak strain value as a reference peak strain value to thereby provide strain measurements that are adjusted relative to a defined time during the cardiac cycle irrespective of when signal acquisition of the obtained MRI image data was initiated during the cardiac cycle. Risk scores, contouring review, contraction pattern from strain measurements provided on a 3-D cardiac model are also disclosed.Type: ApplicationFiled: May 21, 2020Publication date: December 10, 2020Inventor: Nael F. Osman
-
Publication number: 20200077920Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.Type: ApplicationFiled: November 14, 2019Publication date: March 12, 2020Inventor: Nael F. Osman
-
Patent number: 10524687Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.Type: GrantFiled: April 26, 2017Date of Patent: January 7, 2020Assignee: Myocardial Solutions, Inc.Inventor: Nael F. Osman
-
Publication number: 20170311839Abstract: Rapid quantitative evaluations of heart function are carried out with strain measurements from Magnetic Resonance Imaging (MRI) images using a circuit at least partially onboard or in communication with an MRI Scanner and in communication with the at least one display, the circuit including at least one processor that: obtains a plurality of series of MRI images of long and short axis planes of a heart of a patient, with each series of the MRI images is taken over a different single beat of the heart of the patient during an image session that is five minutes or less of active scan time and with the patient in a bore of the MRI Scanner; measures strain of myocardial heart tissue of the heart of the patient based on the plurality of series of MRI images of the heart of the patient; and generates longitudinal and circumferential heart models with a plurality of adjacent compartments, wherein the compartments are color-coded based on the measured strain.Type: ApplicationFiled: April 26, 2017Publication date: November 2, 2017Inventor: Nael F. Osman
-
Patent number: 8380281Abstract: Featured are devices for compression of target tissue while magnetic resonance imaging the target tissue and methods and systems related thereto. The method includes disposing target tissue between the fixed surface and the moveable member of a compression device and compressing the target tissue between the fixed surface and the moveable member. The method also includes acquiring one or more, more specifically a plurality, of sequences of image data of the compressed target tissue using an MRI imaging technique (MRI). In particular embodiments, the MRI technique is a SENC MRI technique, where tissue encoding is done prior to compressing the tissue and acquiring includes adding a gradient moment in the slice-selection direction to cause demodulation with a specific frequency. In further embodiments, the sequences of image data are acquired one of during successive periodic compressions of the tissue or successive periodic relaxation of the tissues.Type: GrantFiled: May 1, 2010Date of Patent: February 19, 2013Assignee: The Johns Hopkins UniversityInventors: Nael F. Osman, Michael A. Jacobs, Ahmed El Harouni, Jakir Hossain
-
Patent number: 8380286Abstract: Featured are a device for compression of target tissue while magnetic resonance imaging the target tissue and methods and systems related thereto. The method includes disposing target tissue between the fixed surface and the moveable member of a compression device and compressing the target tissue between the fixed surface and the moveable member. The method also includes acquiring one or more, more specifically a plurality, of sequences of image data of the compressed target tissue using an MRI imaging technique (MRI). In embodiments, the MRI technique is a SENC MRI technique, where tissue encoding is done prior to compressing the tissue and acquiring includes adding a gradient moment in the slice-selection direction to cause demodulation with a specific frequency, hi further embodiments, the sequences of image data are acquired during a single compression and prior to recovery of magnetization.Type: GrantFiled: November 10, 2006Date of Patent: February 19, 2013Assignee: The Johns Hopkins UniversityInventors: Nael F. Osman, Michael A. Jacobs, Axel Krieger, Ahmed Samir Fahmy
-
Publication number: 20110270079Abstract: Featured are devices for compression of target tissue while magnetic resonance imaging the target tissue and methods and systems related thereto. The method includes disposing target tissue between the fixed surface and the moveable member of a compression device and compressing the target tissue between the fixed surface and the moveable member. The method also includes acquiring one or more, more specifically a plurality, of sequences of image data of the compressed target tissue using an MRI imaging technique (MRI). In particular embodiments, the MRI technique is a SENC MRI technique, where tissue encoding is done prior to compressing the tissue and acquiring includes adding a gradient moment in the slice-selection direction to cause demodulation with a specific frequency. In further embodiments, the sequences of image data are acquired one of during successive periodic compressions of the tissue or successive periodic relaxation of the tissues.Type: ApplicationFiled: May 1, 2010Publication date: November 3, 2011Applicant: The Johns Hopkins UniversityInventors: Nael F. Osman, Michael A. Jacobs, Ahmed El Harouni, Jakir Hossain
-
Publication number: 20100222667Abstract: Featured are a device for compression of target tissue while magnetic resonance imaging the target tissue and methods and systems related thereto. The method includes disposing target tissue between the fixed surface and the moveable member of a compression device and compressing the target tissue between the fixed surface and the moveable member. The method also includes acquiring one or more, more specifically a plurality, of sequences of image data of the compressed target tissue using an MRI imaging technique (MRI). In embodiments, the MRI technique is a SENC MRI technique, where tissue encoding is done prior to compressing the tissue and acquiring includes adding a gradient moment in the slice-selection direction to cause demodulation with a specific frequency, hi further embodiments, the sequences of image data are acquired during a single compression and prior to recovery of magnetization.Type: ApplicationFiled: November 10, 2006Publication date: September 2, 2010Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Nael F. Osman, Michael A. Jacobs, Axel Krieger, Ahmed Samir Fahmy
-
Patent number: 7741845Abstract: Disclosed is a system and method for imaging strain of tissue, such as the heart, in a quantitative manner. The present invention provides images of strain, which corresponds to heart function, by tagging a tissue region of interest, and acquiring multiple images by tuning an MRI RF receiver to frequencies above and below the tagging frequency. Depending on the tagging spatial frequency, and the spread between the high- and low-tuning frequencies, linear measurements of strain may be made on a pixel by pixel basis. By selectively tagging the tissue of interest by use of selective excitation, images may be acquired sufficiently fast to provide anatomical and functional imagery within a single heartbeat. By acquiring additional images, dead tissue may be differentiated from contracting tissue as well as blood.Type: GrantFiled: July 22, 2005Date of Patent: June 22, 2010Assignee: Johns Hopkins UniversityInventor: Nael F. Osman
-
Publication number: 20080315877Abstract: Disclosed is a system and method for imaging strain of tissue, such as the heart, in a quantitative manner. The present invention provides images of strain, which corresponds to heart function, by tagging a tissue region of interest, and acquiring multiple images by tuning an MRI RF receiver to frequencies above and below the tagging frequency. Depending on the tagging spatial frequency, and the spread between the high- and low-tuning frequencies, linear measurements of strain may be made on a pixel by pixel basis. By selectively tagging the tissue of interest by use of selective excitation, images may be acquired sufficiently fast to provide anatomical and functional imagery within a single heartbeat. By acquiring additional images, dead tissue may be differentiated from contracting tissue as well as blood.Type: ApplicationFiled: July 22, 2005Publication date: December 25, 2008Inventor: Nael F. Osman
-
Patent number: 6892089Abstract: The present invention relates to a method of measuring motion of an object such as a heart by magnetic resonance imaging. A pulse sequence is applied to spatially modulate a region of interest of the object and at least one first spectral peak is acquired from the Fourier domain of the spatially modulated object. The inverse Fourier transform information of the acquired first spectral-peaks is computed and a computed first harmonic phase image is determined from each spectral peak. The process is repeated to create a second harmonic phase image from each second spectral peak and the strain is determined from the first and second harmonic phase images. In a preferred embodiment, the method is employed to determine strain within the myocardium and to determine change in position of a point at two different times which may result in an increased distance or reduced distance. The method may be employed to determine the path of motion of a point through a sequence of tag images depicting movement of the heart.Type: GrantFiled: April 14, 2000Date of Patent: May 10, 2005Assignee: Johns Hopkins UniversityInventors: Jerry L. Prince, Nael F. Osman
-
Patent number: 6597935Abstract: The present invention provides methods for real-time measurement of motion of an object such as a portion of a patient in real-time through the use of harmonic phase (HARP) magnetic resonance imaging. This is accomplished by employing certain tagging protocols and imaging protocols. The imaging may be accomplished in two-dimension or three-dimension. In one embodiment, first and second tag pulse sequences are employed to provide two-dimensional pulse strain images. In another embodiment, a first tag pulse sequence is employed to determine a first harmonic phase image and a second tag pulse sequence is employed to determine a second harmonic phase image which is combined with the first image to create tagged images of circumferential and radial strains with third and fourth tag pulse sequences being employed to create images which are combined to establish longitudinal strain and thereby provide a three-dimensional strain image.Type: GrantFiled: February 6, 2001Date of Patent: July 22, 2003Assignee: The Johns Hopkins UniversityInventors: Jerry L. Prince, Nael F. Osman
-
Patent number: 6453187Abstract: A method of measuring motion of an object by magnetic resonance imaging including applying a pulse sequence to spatially modulate a region of interest of said object. At least one spectral peak is acquired from the Fourier domain of the spatially modulated object. The inverse Fourier transform information of the acquired spectral peaks is computed. The angle images are computed from the spectral peak. The angle images employed to measure motion of the object. The method may employ a SPAMM pulse sequence as the pulse sequence. The angle images may be employed to compute directly and automatically, planar strain in two dimensions or a full strain tensor in three dimension. The data may be useful in detection and quantification of myocardial ischemia and infarction. The angle images may also be employed to generate data equivalent to planar tag data automatically and can be employed to generate any desired tag separations.Type: GrantFiled: August 10, 1998Date of Patent: September 17, 2002Assignee: The Johns Hopkins UniversityInventors: Jerry L. Prince, Nael F. Osman
-
Publication number: 20010031037Abstract: The present invention provides methods for real-time measurement of motion of an object such as a portion of a patient in real-time through the use of harmonic phase (HARP) magnetic resonance imaging. This is accomplished by employing certain tagging protocols and imaging protocols. The imaging may be accomplished in two-dimension or three-dimension. In one embodiment, first and second tag pulse sequences are employed to provide two-dimensional pulse strain images. In another embodiment, a first tag pulse sequence is employed to determine a first harmonic phase image and a second tag pulse sequence is employed to determine a second harmonic phase image which is combined with the first image to create tagged images of circumferential and radial strains with third and fourth tag pulse sequences being employed to create images which are combined to establish longitudinal strain and thereby provide a three-dimensional strain image.Type: ApplicationFiled: February 6, 2001Publication date: October 18, 2001Inventors: Jerry L. Prince, Nael F. Osman