Abstract: The purpose of the present invention is to provide a novel system for the delivery of a drug to a posterior segment of the eye. The present invention relates to: a cytophilic peptide-fused high-density lipoprotein (cHDL) which can be used as a carrier for the delivery of a drug to a posterior segment of the eye; a method for producing the cytophilic peptide-fused high-density lipoprotein; a system of the delivery of a drug to a posterior segment of the eye, a pharmaceutical composition, and a system of the delivery of a drug to a posterior segment of the eye, each of which utilizes the cytophilic peptide-fused high-density lipoprotein; and a method for diagnosing, preventing or treating posterior ocular disease.

Abstract: Provided is an optical tomographic imaging apparatus including: a determination unit for determining whether or not an optical member for changing a field angle has been inserted between a scanning unit and an object to be inspected to change a field angle of an acquiring area of a tomographic image; and a switching unit for switching a value of at least one parameter among a control parameter of a control portion for the optical tomographic imaging apparatus, a signal processing parameter of a calculation processing portion, an image processing parameter, and an analysis processing parameter, based on a determination result from the determination unit. Accordingly, a preferred tomographic image of the object is acquired by switching values of various parameters to suitable values even when the optical member for changing a field angle is inserted to change the field angle of the acquiring area of the tomographic image.

Abstract: Focus adjustment is enabled with respect to an object to be inspected even when an optical member for changing a field angle is inserted in order to change the field angle of an acquiring area of a tomographic image, and a clear tomographic image with a focus on the object to be inspected is acquired. In an optical tomographic imaging apparatus, an optical system includes a focus lens configured to focus a measuring light on the object to be inspected. The optical tomographic imaging apparatus includes a unit configured to compensate, when an optical member for changing a field angle is inserted between a scanning unit and the object to be inspected in order to change the field angle of an acquiring area of a tomographic image, a change in a focus position of the focus lens in association with the inserting.

Abstract: An image processing apparatus includes an acquisition unit configured to acquire a tomographic image containing an aqueous humor outflow pathway region that includes at least one of a Schlemm's canal and a collector channel in an anterior ocular segment of a subject's eye, and a generation unit configured to generate an image with the aqueous humor outflow pathway region emphasized or extracted therein based on a luminance value in the tomographic image.

Abstract: Provided is an optical tomographic imaging apparatus including: a determination unit for determining whether or not an optical member for changing a field angle has been inserted between a scanning unit and an object to be inspected to change a field angle of an acquiring area of a tomographic image; and a switching unit for switching a value of at least one parameter among a control parameter of a control portion for the optical tomographic imaging apparatus, a signal processing parameter of a calculation processing portion, an image processing parameter, and an analysis processing parameter, based on a determination result from the determination unit. Accordingly, a preferred tomographic image of the object is acquired by switching values of various parameters to suitable values even when the optical member for changing a field angle is inserted to change the field angle of the acquiring area of the tomographic image.

Abstract: An image processing apparatus includes a determination unit configured to determine, as a partial region of a multi-channel fundus image including an optic disk area and a macular area of a subject's eye, one of a region of the multi-channel fundus image which includes the macular area and a region of the multi-channel fundus image which includes the optic disk area, and a generation unit configured to generate an image in which a difference in color of the partial region is enhanced, by applying to the partial region image processing based on a decorrelation stretching method.

Abstract: The purpose of the present invention is to provide a novel system for the delivery of a drug to a posterior segment of the eye. The present invention relates to: a cytophilic peptide-fused high-density lipoprotein (cHDL) which can be used as a carrier for the delivery of a drug to a posterior segment of the eye; a method for producing the cytophilic peptide-fused high-density lipoprotein; a system of the delivery of a drug to a posterior segment of the eye, a pharmaceutical composition, and a system of the delivery of a drug to a posterior segment of the eye, each of which utilizes the cytophilic peptide-fused high-density lipoprotein; and a method for diagnosing, preventing or treating posterior ocular disease.

Abstract: Focus adjustment is enabled with respect to an object to be inspected even when an optical member for changing a field angle is inserted in order to change the field angle of an acquiring area of a tomographic image, and a clear tomographic image with a focus on the object to be inspected is acquired. In an optical tomographic imaging apparatus, an optical system includes a focus lens configured to focus a measuring light on the object to be inspected. The optical tomographic imaging apparatus includes a unit configured to compensate, when an optical member for changing a field angle is inserted between a scanning unit and the object to be inspected in order to change the field angle of an acquiring area of a tomographic image, a change in a focus position of the focus lens in association with the inserting.

Abstract: An image processing apparatus includes a determination unit configured to determine, as a partial region of a multi-channel fundus image including an optic disk area and a macular area of a subject's eye, one of a region of the multi-channel fundus image which includes the macular area and a region of the multi-channel fundus image which includes the optic disk area, and a generation unit configured to generate an image in which a difference in color of the partial region is enhanced, by applying to the partial region image processing based on a decorrelation stretching method.

Abstract: The present invention provides a pharmaceutical composition for removing drusen, suppressing formation of drusen, and/or treating and/or preventing age-related macular degeneration comprising the compound of formula (I) wherein Ra is independently selected from the group consisting of halo, hydroxy, alkyl, halo-substituted alkyl, aryl, halo- or alkyl-substituted aryl, alkoxy, hydroxy- or carboxy-substituted alkoxy, aryloxy, halo- or alkyl-substituted aryloxy, CHO, C(O)-alkyl, C(O)-aryl, C(O)-alkyl-carboxyl, C(O)-alkylene-carboxy ester and cyano, and m is an integer selected from 0 to 4.

Abstract: In a fundus observation apparatus, an optical system detects interference light generated by superposing signal light having traveled by way of an eye fundus and reference light having traveled by way of a reference optical path. An image forming part forms a cross sectional image based on detection results of the interference light. A specifying part analyzes the cross sectional image to specify an abnormal region located in the vicinity of central fovea of the eye fundus. The association information generating part calculates the distance between the central fovea and the abnormal region and generates association information in which the direction of the abnormal region relative to the central fovea and the distance are associated with each other. The evaluation information generating part generates evaluation information for evaluating the state of the eye fundus based on the association information.

Abstract: The present invention provides a pharmaceutical composition for removing drusen, suppressing formation of drusen, and/or treating and/or preventing age-related macular degeneration comprising the compound of formula (I) wherein Ra is independently selected from the group consisting of halo, hydroxy, alkyl, halo-substituted alkyl, aryl, halo- or alkyl-substituted aryl, alkoxy, hydroxy- or carboxy-substituted alkoxy, aryloxy, halo- or alkyl-substituted aryloxy, CHO, C(O)-alkyl, C(O)-aryl, C(O)-alkyl-carboxyl, C(O)-alkylene-carboxy ester and cyano, and m is an integer selected from 0 to 4.

Abstract: The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

Abstract: In a fundus observation apparatus, an optical system detects interference light generated by superposing signal light having traveled by way of an eye fundus and reference light having traveled by way of a reference optical path. An image forming part forms a cross sectional image based on detection results of the interference light. A specifying part analyzes the cross sectional image to specify an abnormal region located in the vicinity of central fovea of the eye fundus. The association information generating part calculates the distance between the central fovea and the abnormal region and generates association information in which the direction of the abnormal region relative to the central fovea and the distance are associated with each other. The evaluation information generating part generates evaluation information for evaluating the state of the eye fundus based on the association information.

Abstract: An image processing apparatus acquires a tomographic image of an eye to be examined. The image processing apparatus quantifies a distortion in a region determined from the tomographic image. The region includes a photoreceptor layer or a retinal pigment epithelium.

Abstract: The present invention provides agents effective to treat eye diseases, pharmaceutical compositions comprising them, methods for preparing pharmaceuticals for treatment of eye diseases comprising using the agents, use of the agents in manufacture of pharmaceuticals for treatment of eye diseases and methods for treating eye diseases comprising administering the agents or the pharmaceutical compositions. The eye diseases treated by the present invention include particularly glaucoma, especially normal tension glaucoma, or retinitis pigmentosa. The present invention provides the compound of formula (I) wherein R is as defined in the description.

Abstract: There is provided a probe type living body tissue removing device comprising a probe unit having a probe formed in a capillary tube shape and an opening hole portion for internally aspirating a living body tissue, and also having a dissection device arranged within the probe and dissecting the living body tissue aspirated into the probe from the opening hole portion of the probe; wherein an aspiration force supplying device for supplying aspiration force to the probe unit, and a dissection driving source supplying device for supplying power or energy for fulfilling a function of the dissection device to the probe unit are connected to the probe unit; and the probe type living body tissue removing device dissects, and aspirates and removes the living body tissue by the dissecting means while the probe is inserted into the living body tissue and the living body tissue is aspirated through the opening hole portion; and a plurality of the opening hole portions of the probe are arranged.

Abstract: An image processing apparatus acquires a tomographic image of an eye to be examined. The image processing apparatus quantifies a distortion in a region determined from the tomographic image. The region includes a photoreceptor layer or a retinal pigment epithelium.

Abstract: There is provided a probe type living body tissue removing device comprising a probe unit having a probe formed in a capillary tube shape and an opening hole portion for internally aspirating a living body tissue, and also having a dissection device arranged within the probe and dissecting the living body tissue aspirated into the probe from the opening hole portion of the probe; wherein an aspiration force supplying device for supplying aspiration force to the probe unit, and a dissection driving source supplying device for supplying power or energy for fulfilling a function of the dissection device to the probe unit are connected to the probe unit; and the probe type living body tissue removing device dissects, and aspirates and removes the living body tissue by the dissecting means while the probe is inserted into the living body tissue and the living body tissue is aspirated through the opening hole portion; and a plurality of the opening hole portions of the probe are arranged.

Abstract: An ophthalmologic examination apparatus 1 projects a light onto a fundus oculi, detects the reflected light thereof, and forms a 3-dimensional image that represents the morphology of a retina based on the detected results. A stimulation-position specifying part 233 specifies, in the 3-dimensional image, a plurality of stimulation positions that correspond to a plurality of stimulation points Pi in a visual-field examination. A layer-thickness measuring part 235 analyzes the 3-dimensional image to find the layer thickness of the retina at each stimulation position. In addition, a displacement calculation part 234 specifies a related position of the stimulation position. A layer-thickness measuring part 235 finds the layer thickness of the retina at the related position.