Patents by Inventor Nagamasa ASAMI

Nagamasa ASAMI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for sulfating glycosaminoglycan
    Patent number: 10259889
    Abstract: An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent. In the present invention, pH of the strongly basic solution is preferably set to be 11.5 or higher. According to the present invention, for example, a glycosaminoglycan having heparin-like anticoagulant activity can be produced from N-acetylheparosan through one-pot procedure. In one embodiment, a sulfated glycosaminoglycan produced by the method of the present invention has a unique disaccharide composition and is expected to be a novel useful material.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 16, 2019
    Assignee: SEIKAGAKU CORPORATION
    Inventors: Toshikazu Minamisawa, Nagamasa Asami, Hiroshi Fujita, Kiyoshi Suzuki
  • METHOD FOR SULFATING GLYCOSAMINOGLYCAN
    Publication number: 20180086853
    Abstract: An object of the present invention is provide a method for sulfating a glycosaminoglycan in a solution of a non-organic solvent. In the present invention, sulfation reaction of a glycosaminoglycan is performed with a sulfating agent in a strongly basic solution of a non-organic solvent. In the present invention, pH of the strongly basic solution is preferably set to be 11.5 or higher. According to the present invention, for example, a glycosaminoglycan having heparin-like anticoagulant activity can be produced from N-acetylheparosan through one-pot procedure. In one embodiment, a sulfated glycosaminoglycan produced by the method of the present invention has a unique disaccharide composition and is expected to be a novel useful material.
    Type: Application
    Filed: March 31, 2016
    Publication date: March 29, 2018
    Applicant: SEIKAGAKU CORPORATION
    Inventors: Toshikazu MINAMISAWA, Nagamasa ASAMI, Hiroshi FUJITA, Kiyoshi SUZUKI