Patents by Inventor Nagappan Arumugam

Nagappan Arumugam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of carbapenem antibiotic
    Patent number: 8293894
    Abstract: A process for the preparation of a carbapenem of formula (I): in amorphous form wherein R represents hydrogen or COOM and M represents hydrogen or sodium the process including condensing a compound of formula (II): wherein P? denotes a carboxy protecting group, with a compound of formula (III): wherein P? denotes a carboxy protecting group, in the presence of a base to yield a compound of formula (IV): deprotecting both the protecting groups in the compound of formula (IV) in the presence or absence of a sodium ion source, a solvent and in the presence or absence of CO2, gas, extracting the product into an aqueous medium, quenching the aqueous layer of into an alcohol at a temperature, and isolating the carbapenem compound of formula (I) in amorphous form.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: October 23, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Andrew Gnanaprakasam, Nagappan Arumugam, Palanisamy Senthilkumar Udayampalayam, Pandi Suresh Pandian, Venugopal Sivasankaran, Ganapathy Veeramani, Henry Syril Sudhan, Gollapalli Venkateswara Rao
  • Process for the preparation of cilastatin and sodium salt
    Patent number: 8247606
    Abstract: An improved process for preparing Cilastatin Sodium including dissolving Cilastatin acid in a solvent using an organic base, adding sodium salt of a week acid and isolating Cilastatin Sodium.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: August 21, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Ganapathy Panchapakesan, Nagappan Arumugam, Pandi Suresh Pandian, Gollapalli Venkateswara Rao, Subramaniam Ganesan
  • PROCESS FOR THE PREPARATION OF CILASTATIN AND SODIUM SALT
    Publication number: 20120078009
    Abstract: An improved process for preparing Cilastatin Sodium including dissolving Cilastatin acid in a solvent using an organic base, adding sodium salt of a week acid and isolating Cilastatin Sodium.
    Type: Application
    Filed: December 2, 2011
    Publication date: March 29, 2012
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
    Inventors: Ganapathy PANCHAPAKESAN, Nagappan ARUMUGAM, Pandi Suresh PANDIAN, Gollapalli Venkateswara RAO, Subramaniam GANESAN
  • Process for the preparation of Cilastatin and sodium salt
    Patent number: 8134026
    Abstract: The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I). The present invention also provides an isolation technique for Cilastatin acid from the reaction mixture.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: March 13, 2012
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Ganapathy Panchapakesan, Nagappan Arumugam, Pandi Suresh Pandian, Gollapalli Venkateswara Rao, Subramaniam Ganesan
  • AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC
    Publication number: 20090312539
    Abstract: The present invention provides a process for the preparation of the carbapenem antibiotic of formula (I) or its salt in amorphous form. Formula (I) wherein R represents hydrogen or COOM and M represents hydrogen or sodium.
    Type: Application
    Filed: November 20, 2007
    Publication date: December 17, 2009
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Andrew Gnanaprakasam, Nagappan Arumugam, Palanisamy Senthilkumar Udayampalayam, Pandi Suresh Pandian, Venugopal Sivasankaran, Ganapathy Veeramani, Henry Syril Sudhan, Gollapalli Venkateswara Rao
  • Process for the Preparation of Cilastatin and Sodium Salt
    Publication number: 20090143614
    Abstract: The present invention relates to an improved process for the preparation of Cilastatin Sodium of formula (I). The present invention also provides an isolation technique for Cilastatin acid from the reaction mixture.
    Type: Application
    Filed: November 3, 2006
    Publication date: June 4, 2009
    Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED ORCHID TOWERS
    Inventors: Ganapathy Panchapakesan, Nagappan Arumugam, Pandi Suresh Pandian, Gollapalli Venkateswara Rao, Subramaniam Ganesan