Abstract: Peptide-based therapies for a retinal disease, injury, or condition in a subject involve administering to the subject a pharmaceutical composition containing at least one peptide derived from a heat shock protein, including Hsp20 and ?B-crystallin. The administered peptides may be acetylated and/or conjugated to a cell-penetrating peptide. Administration of the peptides may reduce or prevent the loss of at least one retinal cell type, including retinal ganglion cells and retinal endothelial cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The pharmaceutical compositions may be administered intravitreally using an administration device. A single injection may be therapeutically sufficient for treating various ocular conditions.

Abstract: Gene therapy for a retinal disease, injury, or condition in a subject involves administering to the subject a pharmaceutical composition containing a recombinant adeno-associated viral vector encoding at least one heat shock protein, such as Hsp27. A recombinant adeno-associated viral vector can include a promoter sequence that induces production of a heat shock protein specifically in retinal ganglion cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The disclosed viral vector may be included in pharmaceutical compositions that may be administered intravitreally using an administration device. A single injection 10 may be therapeutically sufficient for treating various ocular conditions.

Abstract: Methods of forming a coating system on a surface of a cobalt-based superalloy component are provided. The method includes forming a nickel-based primer layer on the surface of the cobalt-based superalloy component; forming an intermediate nickel-containing layer on the nickel-based primer layer; and heat treating the cobalt-based superalloy component to form a diffusion coating on the surface of the cobalt-based superalloy component. The intermediate nickel-containing layer includes nickel, chromium, and aluminum. Coated cobalt-based superalloy components formed from such a method are also provided.

Abstract: In some implementations, a device may receive training data identifying a set of workflows. The device may generate a set of workflow templates based on the training data identifying the set of workflows, wherein a workflow template, of the set of workflow templates, is associated with a set of steps for completing a task associated with the workflow template. The device may receive, from a client device associated with an entity, a new task for automation using a new workflow. The device may parse the new task to identify one or more steps associated with the new task. The device may identify one or more workflow templates. The device may a workflow recommendation relating to the one or more workflow templates. The device may output workflow data associated with the workflow recommendation.

Abstract: Methods and systems for the flotation recovery of value materials from sulfide mineral sources are disclosed. The flotation recovery of the value materials is performed in a fluidized bed flotation cell utilizing collector materials that include at least one hydrocarbyl group and at least one functional group including sulfur on the hydrocarbyl group, and the hydrocarbyl group includes 2 or more aliphatic carbons and 6 or more total carbons. The methods and systems of the present disclosure advantageously allow for improved recovery of coarse-sized particles, which reduces time and energy expending during sample grinding stages. The methods and systems of the present disclosure also do not exhibit the detrimental frothing behaviors which can be associated with long-chain collectors typically having 6 or more carbon atoms. The systems and methods can be incorporated into existing processing systems to treat samples before or after conventional processing stages.

Abstract: A mesh receiver has a wakeup receiver for reception of a wakeup sequence formed by keyed RF or a sequence of wireless packets and gaps, a transmitter forming low speed RF wakeup sequence to other mesh stations, a mesh receiver for reception of high speed WLAN packets, the transmitter sending a wireless ACK packet in response to a wakeup sequence, the mesh receiver thereafter receiving wireless packets from a remote station, the mesh transmitter sending an ACK, the mesh station thereafter identifying a next hop station, and sending a wakeup sequence to that station, after receipt of an ACK, sending the data, the mesh receiver and mesh transmitter thereafter going to sleep.

Abstract: Multi-beam uniform coverage in a coverage cell(s) in a wireless communications system (WCS) is provided. The WCS includes a number of wireless devices that are typically mounted on a fixed structure to provide coverage for user devices. Each wireless device includes one or more antenna arrays. Each antenna array is controlled via a set of codewords to form one or more RF beams to each cover a respective area in a coverage cell. The codewords are predetermined based on fairness and/or leakage constraints such that the RF beams can be formed in desired geometric shapes and steered toward desired directions to provide a uniform coverage in the coverage cell. By forming the RF beams based on the codewords predetermined based on fairness and/or leakage constraints, it is possible to ensure an equal RF power signal level inside the coverage cell and/or reduced power leakage outside the coverage cell.

Abstract: A network controller in an overlay network maintains collective sets of identity-based policies and identity mappings for onboarded users of the network for informed distribution to network elements across the network. As new users are onboarded, the controller identifies a site of the network at which the user was onboarded and determines identity mappings of the user and applicable policies for distribution to a network element at the identified site. The controller assigns index values to each identity and communicates the indices to network elements with the corresponding identity mappings and policies. The network elements encapsulate cross-site traffic with the index values corresponding to senders so recipient network elements can obtain the index value from encapsulation header formats, query the controller for the corresponding identity mappings, and apply policies to the traffic that are determined to be pertinent based on the sender's identity mappings obtained from the controller.

Abstract: A system includes a sensor device, a hub device, and a keypad device. The keypad device is configured to operate in a keypad mode and a wireless repeater mode. In the wireless repeater mode, the keypad device is in communication with the hub device and in direct communication with the sensor device such that the keypad device, in the wireless repeater mode, acts as a wireless repeater between the hub device and the sensor device.

Abstract: A computer system comprising a processor device configured to switch between switching modes of a load is presented. The switching modes are a complementary switching mode and a non-complementary switching mode of an upper switch and a lower switch of a first half-bridge converter configured to provide a wanted power to a load. The processor device is configured to provide a first upper control signal to the upper switch and a first lower control signal to the lower switch as center aligned PWM-signals at a first PWM period. Responsive to determining that a current switching mode is to be changed at a second PWM period, the processor device is further configured to determine a time-shift for shifting the first upper control signal and the first lower control signal, and to provide the first upper control signal shifted by the time-shift to the upper switch and the first lower control signal shifted by the time-shift to the lower switch at the second PWM period.

Abstract: A brake assembly including a rotor defining an aperture. An axis of rotation of the brake assembly extends through a center of the aperture. A spindle is within the aperture. The spindle is in cooperation with the rotor to restrict independent rotation of the rotor and the spindle about the axis of rotation, restrict axial movement of the rotor relative to the spindle along the axis of rotation, and accommodate radial expansion of the rotor in a plane perpendicular to the axis of rotation.

Abstract: A device, system, and method are directed towards facilitating composing, editing, and displaying a message that includes text and graphics inline. An edit window provides a mechanism for editing the text inline. The message, including text and graphics, may be sent to a remote device. The remote device may display the message, and edit the text and graphics inline, and send a reply message to the original sender.

Abstract: A method for virtual computing instance remediation is provided. Some embodiments include retrieving a first backup of a virtual machine from storage, the first backup comprising configuration information and data of the virtual machine, the configuration information comprising network connectivity information in a first software defined data center (SDDC) running on a first set of host machines. Some embodiments include configuring a second SDDC running on a second set of host machines based on the configuration information, where the second SDDC is network isolated from the first SDDC and powering on the virtual machine from the first backup in the second SDDC. Some embodiments include sending, from the virtual machine to a security platform, behavior information of the virtual machine running in the second SDDC and determining, based on the behavior information, whether the virtual machine running in the second SDDC is infected with malware.

Abstract: A reactor system including a gas distribution assembly and method of using the reactor system are disclosed. The gas distribution assembly includes a gas distribution device, a gas expansion area, and a showerhead plate downstream of the gas distribution device and the expansion area.

Abstract: A capacitive sensing system includes a controller, a node connected to one side of a capacitance, the controller configured to measure the capacitance by measuring a time for a voltage across the capacitance to reach a predetermined reference voltage, a noise measurement circuit configured to measure electrical noise on the node, and the controller receiving the measurement of noise from the noise measurement circuit.

Abstract: Embodiments of the present disclosure relate to a method and an apparatus for alerting threats to users. The apparatus may capture a plurality of signals including at least one of Electro-Magnetic (E-M) signals and sound signals. The E-M signal and sound signals are used to detect objects around the user. A threat to the user is predicted based on the objects around the user and one or more alerts are generated such that the user avoids the threat. The prediction of the threat enables the user to take an action even before the threat has occurred. Also, the alerts are generated based on the prediction such that the user can avoid the threat well in advance of the occurrence of the threat.

Abstract: Techniques and mechanisms for a control plane approach for dense topologies that focusses on discovering shared ECMP groups in the control plane independent of per-prefix learning and then learning prefixes via these shared ECMP groups instead of learning prefixes via one next-hop at a time. In dense topologies, this approach helps minimize BGP path scale, corresponding signaling and enables control plane scaling that is an order of magnitude higher than a traditional eBGP control plane. During link and node topology changes, the described control plane approach enables control plane signaling that is prefix independent and an order of magnitude lower. A control plane approach to path-list sharing and prefix independent signaling on link and node topology changes enables prefix independent convergence (PIC) in scenarios that would not be possible otherwise with traditional FIB driven path-list sharing and PIC.

Abstract: The first circuitry may be operable to establish a first UE Receive (Rx) beam as being for reception of data from a first eNB. The second circuitry may be operable to process a transmission including Downlink Control Information (DCI), wherein the DCI carries an eNB cell-switching indicator. The first circuitry may also be operable to establish a second UE Rx beam as being for reception of data from a second eNB based on the eNB cell-switching indicator.

Abstract: Techniques for generating a visual response to a user input are described. A system may receive a natural language input and use a machine learning model to determine a first component is to determine a response to the natural language input while a second component is to determine supplemental content related to the natural language input. The system may receive, from the first component, first image data corresponding to the response. The system may also receive, from the second component, second image data corresponding to the supplemental content. The system may send, to a display, a command to present the first image data and the second image data.

Abstract: Beamforming codebook synthesis in a wireless communications system (WCS) is provided. A wireless node simultaneously emits multiple reference beams in a coverage area based on a set of codewords that is optimized for a specific number of antenna elements in an antenna array. The wireless node may need to emit the reference beams using a different number of the antenna elements in the antenna array. Herein, the wireless node is configured to determine a different set(s) of codewords that is fine tuned for forming an identical number of the reference beams from a different number of the antenna elements and steered toward identical directions. In addition, the wireless node can dynamically select an appropriate set of codewords in response to different operating conditions. As such, it is possible to switch transparently, from both wireless node and end user perspectives, between different antenna array configurations under different operating conditions.