Patents by Inventor Nagaraja K. R. Rao

Nagaraja K. R. Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using diketopiperazines and composition containing them
    Publication number: 20030225103
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells.
    Type: Application
    Filed: March 25, 2003
    Publication date: December 4, 2003
    Applicant: DMI BioSciences, Inc.
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K.R. Rao, Greg Thomas
  • Metal-binding compounds and uses therefor
    Publication number: 20030130185
    Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
    Type: Application
    Filed: June 27, 2002
    Publication date: July 10, 2003
    Inventors: David Bar-Or, C. Gerald Curtis, Edward Lau, Nagaraja K.R. Rao, James V. Winkler, Wannell M. Crook
  • Method of using diketopiperazines and composition containing them
    Patent number: 6555543
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula: wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: April 29, 2003
    Assignee: DMI BioSciences, Inc.
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K. R. Rao, Greg Thomas
  • Metal-binding compounds and uses therefor
    Publication number: 20030060408
    Abstract: The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compound as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
    Type: Application
    Filed: February 13, 2002
    Publication date: March 27, 2003
    Inventors: David Bar-Or, C. Gerald Curtis, Edward Lau, Nagaraja K.R. Rao, James V. Winkler, Wannell M. Crook
  • Method of using diketopiperazines and composition containing them
    Publication number: 20020052381
    Abstract: The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells.
    Type: Application
    Filed: August 2, 2001
    Publication date: May 2, 2002
    Inventors: David Bar-Or, C. Gerald Curtis, Nagaraja K.R. Rao, Greg Thomas
  • Method of synthesizing diketopiperazines
    Publication number: 20020038026
    Abstract: The invention provides a method of synthesizing a diketopiperazine of the formula: 1
    Type: Application
    Filed: August 2, 2001
    Publication date: March 28, 2002
    Inventors: Nagaraja K.R. Rao, Stephen Turner