Patents by Inventor Nagarjuna Palyam
Nagarjuna Palyam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11970512Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: GrantFiled: September 2, 2021Date of Patent: April 30, 2024Assignee: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Patent number: 11352486Abstract: A polymer composition that comprises an olefinic polymer, a flame retardant that includes a halogen-free mineral filler, and a compatibilizing agent is provided. The halogen-free mineral filler constitutes from about 20 wt. % to about 80 wt. % of the composition. The composition may exhibit a degree of water uptake of about 5 wt. % or less after being immersed in water for seven days at a temperature of 23° C.Type: GrantFiled: August 24, 2020Date of Patent: June 7, 2022Assignee: Celanese EVA Performance Polymers LLCInventors: Jeffrey Charles Haley, Nagarjuna Palyam, Christian Schneider, Chelsea Ringham
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Publication number: 20220056066Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: ApplicationFiled: September 2, 2021Publication date: February 24, 2022Inventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Patent number: 11117920Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: GrantFiled: June 17, 2019Date of Patent: September 14, 2021Assignee: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Patent number: 11028114Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: GrantFiled: August 2, 2019Date of Patent: June 8, 2021Assignee: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Publication number: 20200392317Abstract: A polymer composition that comprises an olefinic polymer, a flame retardant that includes a halogen-free mineral filler, and a compatibilizing agent is provided. The halogen-free mineral filler constitutes from about 20 wt. % to about 80 wt. % of the composition. The composition may exhibit a degree of water uptake of about 5 wt. % or less after being immersed in water for seven days at a temperature of 23° C.Type: ApplicationFiled: August 24, 2020Publication date: December 17, 2020Inventors: Jeffrey Charles Haley, Nagarjuna Palyam, Christian Schneider, Chelsea Ringham
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Patent number: 10752760Abstract: A polymer composition that comprises an olefinic polymer, a flame retardant that includes a halogen-free mineral filler, and a compatibilizing agent is provided. The halogen-free mineral filler constitutes from about 20 wt. % to about 80 wt. % of the composition. The composition may exhibit a degree of water uptake of about 5 wt. % or less after being immersed in water for seven days at a temperature of 23° C.Type: GrantFiled: June 27, 2018Date of Patent: August 25, 2020Assignee: Celanese EVA Performance Polymers CorporationInventors: Jeffrey Charles Haley, Nagarjuna Palyam, Christian Schneider, Chelsea Ringham
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Publication number: 20200002368Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: ApplicationFiled: August 2, 2019Publication date: January 2, 2020Inventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Publication number: 20190345187Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: ApplicationFiled: June 17, 2019Publication date: November 14, 2019Inventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Patent number: 10323057Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: GrantFiled: October 6, 2014Date of Patent: June 18, 2019Assignee: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
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Publication number: 20190002677Abstract: A polymer composition that comprises an olefinic polymer, a flame retardant that includes a halogen-free mineral filler, and a compatibilizing agent is provided. The halogen-free mineral filler constitutes from about 20 wt. % to about 80 wt. % of the composition. The composition may exhibit a degree of water uptake of about 5 wt. % or less after being immersed in water for seven days at a temperature of 23° C.Type: ApplicationFiled: June 27, 2018Publication date: January 3, 2019Inventors: Jeffrey Charles Haley, Nagarjuna Palyam, Christian Schneider, Chelsea Ringham
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Publication number: 20160215012Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.Type: ApplicationFiled: October 6, 2014Publication date: July 28, 2016Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Stephen Davis, Brice E Uno, Justin Struble, lan Dailey, Kaitlyn C Gray, David M Knapp, Pulin Wang, Nagarjuna Palyam
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Publication number: 20160068656Abstract: Cellulose ester plastics may be formulated to have a depressed melt processing temperatures, improved heat resistance, increased mechanical stability, or some combination thereof. For example, in some instances, a cellulose ester plastic comprising: a cellulose ester at about 20% to about 90% by weight of the cellulose ester plastic; and a plasticizer that comprises a carbonate ester, a polyol benzoate, or both, wherein the plasticizer is at about 2% to about 40% by weight of the cellulose ester plastic, wherein the cellulose ester plastic is melt processable.Type: ApplicationFiled: September 9, 2015Publication date: March 10, 2016Applicant: Celanese Acetate LLCInventors: Naresh Budhavaram, Lizbeth Milward Niebla, Michael Combs, Wendy C. Bisset, Nagarjuna Palyam, Christopher McGrady, Marilyn T. Collins, Bing Lu, Adam Larkin, Syed Mazahir
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Publication number: 20160068665Abstract: Cellulose ester plastics may be formulated to have a depressed melt processing temperatures, improved heat resistance, increased mechanical stability, or some combination thereof. For example, in some instances, a cellulose ester plastic may include a plasticized cellulose ester at about 1% to about 99% by weight of the cellulose ester plastic, the plasticized cellulose ester consisting of a cellulose ester at about 60% to about 90% by weight of the plasticized cellulose ester and a plasticizer at about 10% to about 40% by weight of the plasticized cellulose ester, wherein the plasticizer comprises a carbonate ester, a polyol benzoate, or both; and a thermoplastic polymer at about 1% to about 99% by weight of the cellulose ester plastic; and wherein the cellulose ester plastic is melt processable.Type: ApplicationFiled: September 9, 2015Publication date: March 10, 2016Applicant: Celanese Acetate LLCInventors: Naresh Budhavaram, Abhishek Ambekar, Michael Combs, Christopher McGrady, Adam Larkin, Bing Lu, Nagarjuna Palyam, Marilyn T. Collins, Lizbeth Milward Niebla, Wendy C. Bisset, Syed Mazahir
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Publication number: 20160053152Abstract: A process for producing an anti-fog consumer product. The process comprises the steps of forming a precursor composition comprising cellulose acetate and plasticizer to yield a substantially rigid consumer product having an outer surface; and saponifying at least a portion of the substantially rigid consumer product to yield the anti-fog consumer product having a degree of substitution at the outer surface of less than 0.75.Type: ApplicationFiled: August 14, 2015Publication date: February 25, 2016Inventors: Kevin Parker, Joanna Marshall, Naresh Budhavaram, Bing Lu, Nagarjuna Palyam, Marilyn Collins, Michael Combs, Christopher McGrady