Patents by Inventor Nagendu B. Dev

Nagendu B. Dev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrically induced vessel vasodilation
    Patent number: 6865416
    Abstract: The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double-balloon catheter system incorporating electroporation technology has been designed and is used to apply the electrical impulse endoluminally.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: March 8, 2005
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Sukhendu B. Dev, Gunter A. Hofmann
  • Skin and muscle-targeted gene therapy by pulsed electrical field
    Publication number: 20040092860
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: June 9, 2003
    Publication date: May 13, 2004
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Skin and muscle-targeted gene therapy by pulsed electrical field
    Patent number: 6697669
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: February 24, 2004
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Skin and muscle-targeted gene therapy by pulsed electrical field
    Patent number: 6654636
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: November 25, 2003
    Assignee: Genetronics, Inc.
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Edward Nolan, Dietmar P. Rabussay, Arnt Tonnessen, Georg Widera, Lei Zhang
  • Electroporation-enhanced inhibition of vascular neointimal hyperplasia
    Publication number: 20020183684
    Abstract: The present invention provides methods for inhibiting or preventing hyperplastic intimal growth by intravascular administration of a composition comprising heparin, or a derivative thereof in conjunction with at least one electric pulse having sufficient strength and duration to cause electroporation of the cells lining the blood vessel. Such treatment inhibits or prevents hyperplastic intimal growth in vessels, such as arteries, as compared with a non-electroporated vessel to which the heparin, or derivative thereof, is administered.
    Type: Application
    Filed: June 12, 2002
    Publication date: December 5, 2002
    Applicant: GENETRONICS
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Sukhendu B. Dev, Dietmar P. Rabussay
  • SKIN AND MUSCLE-TARGETED GENE THERAPY BY PULSED ELECTRICAL FIELD
    Publication number: 20020099323
    Abstract: The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
    Type: Application
    Filed: July 13, 1999
    Publication date: July 25, 2002
    Inventors: NAGENDU B. DEV, GUNTER A. HOFMANN, EDWARD NOLAN, DIETMAR P. RABUSSAY, ARNT TONNESSEN, GEORG WIDERA, LEI ZHANG
  • Electroporation-mediated intravascular delivery
    Publication number: 20020045853
    Abstract: A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least one cell in a vessel in a subject.
    Type: Application
    Filed: December 14, 2001
    Publication date: April 18, 2002
    Applicant: GENETRONICS, INC.
    Inventors: Sukhendu B. Dev, Nagendu B. Dev, Gunter A. Hofmann
  • Electroporation-enhanced inhibition of vascular neointimal hyperplasia
    Publication number: 20020040204
    Abstract: The present invention provides methods for inhibiting or preventing hyperplastic intimal growth by intravascular administration of a composition comprising heparin, or a derivative thereof in conjunction with at least one electric pulse having sufficient strength and duration to cause electroporation of the cells lining the blood vessel. Such treatment inhibits or prevents hyperplastic intimal growth in vessels, such as arteries, as compared with a non-electroporated vessel to which the heparin, or derivative thereof, is administered.
    Type: Application
    Filed: December 15, 2000
    Publication date: April 4, 2002
    Inventors: Nagendu B. Dev, Gunter A. Hofmann, Sukhendu B. Dev, Dietmar P. Rabussay
  • Electrically induced vessel vasodilation
    Patent number: 6347247
    Abstract: The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double-balloon catheter system incorporating electroporation technology has been designed and is used to apply the electrical impulse endoluminally.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: February 12, 2002
    Assignee: Genetronics Inc.
    Inventors: Nagendu B. Dev, Sukhendu B. Dev, Gunter A. Hofmann
  • Electrically induced vessel vasodilation
    Publication number: 20020016615
    Abstract: The invention provides methods for inducing or increasing the vasodilation of a vessel. The invention further provides methods for inducing or increasing the flow of fluid through a vessel. An electrical impulse is applied to the vessel in order to induce or increase vessel vasodilation or to induce or increase the flow of fluid through the vessel. In a particular embodiment, a novel double-balloon catheter system incorporating electroporation technology has been designed and is used to apply the electrical impulse endoluminally.
    Type: Application
    Filed: October 1, 2001
    Publication date: February 7, 2002
    Inventors: Nagendu B. Dev, Sukhendu B. Dev, Gunter A. Hofmann
  • Electroporation-mediated intravascular delivery
    Patent number: 5944710
    Abstract: A method for sustained intravascular delivery via electroporation is provided. The method is useful for delivery of therapeutic compositions such as antithrombotic and anticoagulant agents. The invention also provides a catheter apparatus for introducing a composition into at least one cell in a vessel in a subject.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: August 31, 1999
    Assignee: Genetronics, Inc.
    Inventors: Sukhendu B. Dev, Nagendu B. Dev, Gunter A. Hofmann