Patents by Inventor Nagesh K. Mahanthappa

Nagesh K. Mahanthappa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PRO/LATENT-MYOSTATIN ANTIBODIES AND USES THEREOF
    Publication number: 20240374718
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Application
    Filed: February 2, 2024
    Publication date: November 14, 2024
    Inventors: Michelle STRAUB, Dong Yun LEE, William K. MCCONAUGHY, Katherine Jane TURNER, Nagesh K. MAHANTHAPPA, Justin W. JACKSON
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20240368261
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: October 17, 2023
    Publication date: November 7, 2024
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • Compositions for making and using anti-Myostatin antibodies
    Patent number: 11925683
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: March 12, 2024
    Assignee: Scholar Rock, Inc.
    Inventors: Michelle Straub, Dong Yun Lee, William K. McConaughy, Katherine Jane Turner, Nagesh K. Mahanthappa, Justin W. Jackson
  • Compositions and methods for growth factor modulation
    Patent number: 11827698
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: March 9, 2021
    Date of Patent: November 28, 2023
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • ANTI-PRO/LATENT-MYOSTATIN ANTIBODIES AND USES THEREOF
    Publication number: 20220152200
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Application
    Filed: September 3, 2021
    Publication date: May 19, 2022
    Inventors: Michelle STRAUB, Dong Yun LEE, William K. MCCONAUGHY, Katherine Jane TURNER, Nagesh K. MAHANTHAPPA, Justin W. JACKSON
  • Methods for making and using anti-myostatin antibodies
    Patent number: 11135291
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: October 5, 2021
    Assignee: Scholar Rock, Inc.
    Inventors: Michelle Straub, Dong Yun Lee, William K. McConaughy, Katherine Jane Turner, Nagesh K. Mahanthappa, Justin W. Jackson
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20210284722
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: March 9, 2021
    Publication date: September 16, 2021
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • Compositions and methods for growth factor modulation
    Patent number: 10981981
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: April 20, 2021
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20200131259
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: January 7, 2020
    Publication date: April 30, 2020
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • Compositions and methods for growth factor modulation
    Patent number: 10597443
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: March 24, 2020
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR MODULATING CELL SIGNALING
    Publication number: 20200024339
    Abstract: The present invention provides growth factor-directed agents (GDAs), which act as either antagonists or agonists of cell signaling, particularly in the TGF-beta and related extracellular matrix signaling pathways. Such GDAs include monoclonal antibodies, fusion proteins and novel polypeptide compositions and/or conjugates of these compositions.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 23, 2020
    Inventors: Timothy Alan Springer, Leonard Ira Zon, Nagesh K. Mahanthappa
  • ANTI-PRO/LATENT-MYOSTATIN ANTIBODIES AND USES THEREOF
    Publication number: 20190365891
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 5, 2019
    Inventors: Michelle Straub, Dong Yun Lee, William K. McConaughy, Katherine Jane Turner, Nagesh K. Mahanthappa, Justin W. Jackson
  • Anti-pro/latent-myostatin antibodies and uses thereof
    Patent number: 10307480
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: June 4, 2019
    Assignee: Scholar Rock, Inc.
    Inventors: Michelle Straub, Dong Yun Lee, William K. McConaughy, Katherine Jane Turner, Nagesh K. Mahanthappa, Justin W. Jackson
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20190085067
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: December 4, 2018
    Publication date: March 21, 2019
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20180022798
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: August 8, 2017
    Publication date: January 25, 2018
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20180016332
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: July 26, 2017
    Publication date: January 18, 2018
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • ANTI-PRO/LATENT-MYOSTATIN ANTIBODIES AND USES THEREOF
    Publication number: 20170333558
    Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.
    Type: Application
    Filed: November 6, 2015
    Publication date: November 23, 2017
    Inventors: Michelle Straub, Dong Yun Lee, William K. McConaughy, Jared J. Sheehan, Katherine Jane Turner, Nagesh K. Mahanthappa, Gregory J. Carven, Justin W. Jackson
  • Compositions and methods for growth factor modulation
    Patent number: 9758576
    Abstract: Provided herein are antibodies that bind growth factor prodomain complexes, for example, growth factor prodomain complexes that include GDF-8 growth factor and GDF-8 prodomain. Also included are antibodies that bind growth factor prodomain complexes that have been altered by proteolytic processing.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 12, 2017
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • Compositions and methods for growth factor modulation
    Patent number: 9758577
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 12, 2017
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20170210798
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: January 9, 2017
    Publication date: July 27, 2017
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub