Patents by Inventor Nagesh Pulicherla

Nagesh Pulicherla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral vectors with modified transduction profiles and methods of making and using the same
    Patent number: 9409953
    Abstract: The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: August 9, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Nagesh Pulicherla
  • VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20140056854
    Abstract: The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or more mutations, wherein the mutation(s) result in a phenotype of decreased liver transduction and/or reduced glycan binding affinity as compared to a control. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject.
    Type: Application
    Filed: February 10, 2012
    Publication date: February 27, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Nagesh Pulicherla