Patents by Inventor Nageswara Rao Bolneni

Nageswara Rao Bolneni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of (R)-4-propyl pyrrolidine-2-one, a key intermediate for synthesis of brivaracetam
    Patent number: 11884623
    Abstract: A process for the preparation of (R)-4-propyl-pyrrolidine-2-one, is provided which includes enzymatic conversion of dimethyl 3-propyl pentanedioate selectively into (S)-3-(2-methoxy-2-oxoethyl) hexanoic acid using Novozyme's Promea® enzyme, amidation of (S)-3-(2-methoxy-2-oxoethyl) hexanoic acid, followed by ester hydrolysis to obtain (S)-3-(2-amino-2-oxoethyl) hexanoic acid having high chiral purity >99% and converting the amide to amine by Hofmann rearrangement and cyclization resulting in (R)-4-propyl-pyrrolidine-2-one. It is further converted to Brivaracetam by N-alkylation with 2-bromobutyric acid, esterification followed by enzymatic resolution.
    Type: Grant
    Filed: July 5, 2022
    Date of Patent: January 30, 2024
    Assignee: DIVI'S LABORATORIES LTD.
    Inventors: Murali Krishna Prasad Divi, Nageswara Rao Bolneni, Leela Maheswara Rao Bandarupalli
  • PROCESS FOR THE PREPARATION OF (R)-4-PROPYL PYRROLIDINE-2-ONE, A KEY INTERMEDIATE FOR SYNTHESIS OF BRIVARACETAM
    Publication number: 20230373914
    Abstract: A process for the preparation of (R)-4-propyl-pyrrolidine-2-one, is provided which includes enzymatic conversion of dimethyl 3-propyl pentanedioate selectively into (S)-3-(2-methoxy-2-oxoethyl) hexanoic acid using Novozyme's Promea® enzyme, amidation of (S)-3-(2-methoxy-2-oxoethyl) hexanoic acid, followed by ester hydrolysis to obtain (S)-3-(2-amino-2-oxoethyl) hexanoic acid having high chiral purity>99% and converting the amide to amine by Hofmann rearrangement and cyclization resulting in (R)-4-propyl-pyrrolidine-2-one. It is further converted to Brivaracetam by N-alkylation with 2-bromobutyric acid, esterification followed by enzymatic resolution.
    Type: Application
    Filed: July 5, 2022
    Publication date: November 23, 2023
    Inventors: Murali Krishna Prasad DIVI, Nageswara Rao BOLNENI, Leela Maheswara Rao BANDARUPALLI
  • Process for the preparation of (1S, 3S, 5S)-2-[2(S)--amino-2-(3-hydroxy-1-adamantan-1-yl) acetyl]-2-azabicyclo [3.1.0] hexane-3-carbonitrile
    Patent number: 8664443
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-2-[2(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: March 4, 2014
    Assignee: Divi's Laboratories Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • PROCESS FOR THE PREPARATION OF (1S, 3S, 5S)-2-[2(S)-2-AMINO-2-(3-HYDROXY-1-ADAMANTAN-1-YL ACETYL]-2-AZABICYCLO [3.1.0] HEXANE-3-CARBONITRILE
    Publication number: 20130317235
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-242(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Application
    Filed: September 4, 2012
    Publication date: November 28, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • Process for isomerisation of lycopene in the presence of thiourea
    Patent number: 8389790
    Abstract: The present invention relates to isomerization of Z-lycopene in mixtures of isomers to mixtures enriched with all E-lycopene.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: March 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Ramesh Babu Kodali
  • PREPARATION OF 2-(4-BROMOPHENYL)-2-METHYLPROPANOIC ACID
    Publication number: 20120309973
    Abstract: Selective bromination of 2-methyl-2-phenylpropanoic acid in aqueous medium is described to obtain pure 2-(4-bromophenyl)-2-methylpropanoic acid, which is a useful key intermediate in the process of manufacturing pure fexofenadine.
    Type: Application
    Filed: August 29, 2011
    Publication date: December 6, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Krishnaji Rao Mutyala
  • PROCESS FOR ISOMERISATION OF LYCOPENE IN THE PRESENCE OF THIOUREA
    Publication number: 20120197055
    Abstract: The present invention relates to isomerization of Z-lycopene in mixtures of isomers to mixtures enriched with all E-lycopene.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 2, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Ramesh Babu Kodali