Abstract: The present disclosure relates to compounds useful in the treatment, imaging, and/or diagnosis of Epstein-Barr virus (EBV)-positive cells, such as cancer.

Abstract: The present disclosure provides peptides useful as inhibitors of the dimerization interface of EBNA1. The present disclosure also provides methods for treating and imaging EBV-associated cancers.

Abstract: The present disclosure relates to compounds useful in the treatment, imaging, and/or diagnosis of Epstein-Barr virus (EBV)-positive cells, such as cancer.

Abstract: The present disclosure provides peptides useful as inhibitors of the dimerization interface of EBNA1. The present disclosure also provides methods for treating and imaging EBV-associated cancers.

Abstract: This invention provides a nucleus-permeable small-molecule inhibitor, L2P4 (where L2 is 4-(4-(Diethylamino)styryl)-N-carboxymethylpyridinium chloride and P4 is an amino acid sequence comprising CAhxYFMVFGGRrRK and they were coupled through amide bond) and synthesis thereof, which effectively targets the dimerization interface of EBNA1, a critical process for the growth of EBVs and the associated tumors. The present invention also provides method of treating and imaging EBV-associated cancers.

Abstract: This invention provides a nucleus-permeable small-molecule inhibitor, L2P4 (where L2 is 4-(4-(Diethylamino)styryl)-N-carboxymethylpyridinium chloride and P4 is an amino acid sequence comprising CAhxYFMVFGGRrRK and they were coupled through amide bond) and synthesis thereof, which effectively targets the dimerization interface of EBNA1, a critical process for the growth of EBVs and the associated tumors. The present invention also provides method of treating and imaging EBV-associated cancers.

Abstract: Disclosed is a device and related method for biological manipulation. With greater particularity, disclosed is a novel device and method for uniform cellular manipulation with economies of scale and operational uniformity. The device and related method utilize a cellular wounder (101) to uniformly remove portions of a cell monolayer in a multi-well plate (303) to create uniform cell samples with reduced time and expense to the user. The multi-channel mechanical wounder is a useful tool for performing cellular wounding by providing consistent and even denudation of a defined area of monolayer of cells in standard culture plates. This easy-to-assemble and user friendly device is most applicable for high throughput screening of samples such as in the manipulation of cells for cell migration or wound healing assay preparation.

Abstract: Disclosed is a device and related method for biological manipulation. With greater particularity, disclosed is a novel device and method for uniform cellular manipulation with economies of scale and operational uniformity. The device and related method utilize a cellular wounder (101) to uniformly remove portions of a cell monolayer in a multi-well plate (303) to create uniform cell samples with reduced time and expense to the user. The multi-channel mechanical wounder is a useful tool for performing cellular wounding by providing consistent and even denudation of a defined area of monolayer of cells in standard culture plates. This easy-to-assemble and user friendly device is most applicable for high throughput screening of samples such as in the manipulation of cells for cell migration or wound healing assay preparation.