Patents by Inventor Nai-Kuei Huang

Nai-Kuei Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dual-action compounds targeting adenosine Areceptor and adenosine transporter for prevention and treatment of neurodegenerative diseases
    Patent number: 10342818
    Abstract: The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A2A receptor (A2AR) and the equilibrative nucleoside transporter 1 (ENT1).
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: July 9, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Yun-Lian Lin, Yijuang Chern, Jim-Min Fang, Jung-Hsing Lin, Nai-Kuei Huang
  • Compounds for use in prevention and treatment of neurodegenerative diseases and pain
    Patent number: 10301348
    Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: May 28, 2019
    Assignee: ACADEMIA SINICA
    Inventors: Jim-Min Fang, Yun-Lian Lin, Jung-Hsin Lin, Chun-Jung Lin, Yijuang Chern, Nai-Kuei Huang, Hung-Li Wang, Benjamin Pang-hsien Tu, Chih-Cheng Chen
  • COMPOUNDS FOR USE IN PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES AND PAIN
    Publication number: 20160264613
    Abstract: Compounds for use in prevention and treatment of neurodegenerative disease and pain are disclosed. In one embodiment of the invention, the compound is selected from the group consisting of N6-[(3-halothien-2-yl)methyl]adenosine, N6-[(4-halothien-2-yl)methyl]adenosine, and N6-[(5-halothien-2-yl)methyl]adenosine. In another embodiment of the invention, the compound is selected from the group consisting of N6-[(2-bromothien-3-yl)methyl]adenosine, N6-[(4-bromothien-3-yl)methyl]adenosine, N6-[(5-bromothien-3-yl)methyl]adenosine N6-[(2-chlorothien-3-yl)methyl]adenosine, N6-[(4-chlorothien-3-yl)methyl]adenosine, and N6-[(5-chlorothien-3-yl)methyl]adenosine. Also disclosed are methods of making and using the same.
    Type: Application
    Filed: October 22, 2014
    Publication date: September 15, 2016
    Inventors: Jim-Min Fang, Yun-Lian LIn, Jung-Hsin Lin, Chun-Jung Lin, Yijuang Chem, Nai-Kuei Huang, Hung-Li Wang, Benjamin Pang-hsien Tu, Chih-Cheng Chen
  • Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases
    Publication number: 20150374737
    Abstract: The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A2A receptor (A2AR) and the equilibrative nucleoside transporter 1 (ENT1).
    Type: Application
    Filed: September 10, 2015
    Publication date: December 31, 2015
    Inventors: Yun-Lian LIN, Yijuang Chern, Jim-Min Fang, Jung-Hsing Lin, Nai-Kuei Huang
  • Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases
    Publication number: 20120295863
    Abstract: The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A2A receptor (A2AR) and the equilibrative nucleoside transporter 1 (ENT1).
    Type: Application
    Filed: November 12, 2010
    Publication date: November 22, 2012
    Inventors: Yun-Lian Lin, Yijuang Chern, Jim-Min Fang, Jung-Hsing Lin, Nai-Kuei Huang
  • Method of making and using an adenosine analogue
    Patent number: 8129357
    Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: March 6, 2012
    Assignee: Academia Sinica
    Inventors: Yijuang Chern, Yun-Lian Lin, Nai-Kuei Huang, Jung-Hsing Lin, Jim-Min Fang, Chia-I Lin
  • Method of making and using an adenosine analogue
    Publication number: 20080176816
    Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.
    Type: Application
    Filed: December 6, 2007
    Publication date: July 24, 2008
    Inventors: Yijuang Chern, Yun-Lian Lin, Nai-Kuei Huang, Jung-Hsing Lin, Jim-Min Fang, Chia-I Lin
  • Therapeutic extracts
    Patent number: 7351434
    Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: April 1, 2008
    Assignee: Academia Sinica
    Inventors: Yijuang Chern, Yun-Lian Lin, Nai-Kuei Huang
  • Therapeutic gastrodia extracts
    Publication number: 20070237840
    Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.
    Type: Application
    Filed: April 7, 2006
    Publication date: October 11, 2007
    Applicant: Academia Sinica
    Inventors: Yijuang Chern, Yun-Lian Lin, Nai-Kuei Huang