Patents by Inventor Naichen Yu

Naichen Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10725023
    Abstract: A method of identifying a therapeutic compound for treating cancer in a human subject, the method including: providing a device that measures cell-substrate impedance; culturing cancer cells in the at least two wells, wherein the cancer cells are obtained from a human subject and have a receptor tyrosine kinase (RTK) pathway; adding to a first well a proposed therapeutic compound that affects an RTK pathway and an RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells; and determining a difference in impedance or optionally in cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells of the human subject.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: July 28, 2020
    Assignee: ACEA Biosciences, Inc.
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Publication number: 20190195861
    Abstract: A method of identifying a therapeutic compound for treating cancer in a human subject, the method including: providing a device that measures cell-substrate impedance; culturing cancer cells in the at least two wells, wherein the cancer cells are obtained from a human subject and have a receptor tyrosine kinase (RTK) pathway; adding to a first well a proposed therapeutic compound that affects an RTK pathway and an RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells; and determining a difference in impedance or optionally in cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells of the human subject.
    Type: Application
    Filed: December 31, 2018
    Publication date: June 27, 2019
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Patent number: 10168318
    Abstract: A method of identifying a potential therapeutic compound that affects a Receptor Tyrosine Kinase (RTK) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a RTK pathway and a RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: January 1, 2019
    Assignee: ACEA Biosciences, Inc.
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Patent number: 10067121
    Abstract: Use of cell-substrate impedance based methods for screening for agonists of G-Protein Coupled Receptors (GPCRs) or inhibitors of a Receptor Tyrosine Kinases (RTKs), identifying compounds that affect GPCR or RTK pathways, validating molecular targets involved in a GPCR or RTK signaling pathways, monitoring dose-dependent functional activation of GPCR or RTK; determining desensitization of a GPCR and identifying a compound capable of affecting RTK activity in cancer cell proliferation.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: September 4, 2018
    Assignee: ACEA Biosciences, Inc.
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Publication number: 20170370907
    Abstract: A method of identifying a potential therapeutic compound that affects a Receptor Tyrosine Kinase (RTK) pathway in cancer cells, which includes: providing a device capable of measuring cell-substrate impedance; culturing cancer cells in serum-free media in at least two wells of the device; adding to a first well a proposed therapeutic compound that affects a RTK pathway and a RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells and optionally determining cell indices from the monitored cell-substrate impedance; and determining a difference in impedance or optionally cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells.
    Type: Application
    Filed: June 2, 2017
    Publication date: December 28, 2017
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Publication number: 20150185206
    Abstract: Use of cell-substrate impedance based methods for screening for agonists of G-Protein Coupled Receptors (GPCRs) or inhibitors of a Receptor Tyrosine Kinases (RTKs), identifying compounds that affect GPCR or RTK pathways, validating molecular targets involved in a GPCR or RTK signaling pathways, monitoring dose-dependent functional activation of GPCR or RTK; determining desensitization of a GPCR and identifying a compound capable of affecting RTK activity in cancer cell proliferation.
    Type: Application
    Filed: November 13, 2014
    Publication date: July 2, 2015
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Patent number: 8916357
    Abstract: Methods for identifying a compound capable of interacting with a Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance, adding test cells expressing a RTK to the device, measuring first impedances, adding a compound to at least one compound well and adding a vehicle control to at least one control well, measuring second impedances of the compound well and the control well, determining the change in the impedance for the compound well and the one control well, comparing the change in impedance between the compound well and the control well, and identifying the compound interacts with the RTK if the comparison demonstrates a significant difference between the change in impedance.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: December 23, 2014
    Assignee: ACEA Biosciences, Inc.
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Publication number: 20120295253
    Abstract: Methods for identifying a compound capable of interacting with a Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance, adding test cells expressing a RTK to the device, measuring first impedances, adding a compound to at least one compound well and adding a vehicle control at least one control well, measuring second impedances of the compound well and the control well, determining the change in the impedance for the compound well and the one control well, comparing the change in impedance between the compound well and the control well, and identifying the compound interacts with the RTK if the comparison demonstrates a significant difference between the change in impedance.
    Type: Application
    Filed: August 7, 2012
    Publication date: November 22, 2012
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiaobo Wang
  • Patent number: 8263375
    Abstract: The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, measuring first impedances of the wells and optionally determining first cell indices from the first impedances, adding a compound to at least one well containing test cells to form at least one compound well and adding a vehicle control to at least another well containing test cells to form at least one control well, measuring second impedances of the compound well and the control well and optionally determining second cell indices from the second impedances, determining the change in the impedance or cell index for the compound well and the one control well, comparing the change in impedance or cell index between the compound well and the control
    Type: Grant
    Filed: August 4, 2005
    Date of Patent: September 11, 2012
    Assignee: ACEA Biosciences
    Inventors: Yama A. Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiabo Wang
  • Publication number: 20060050596
    Abstract: The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, measuring first impedances of the wells and optionally determining first cell indices from the first impedances, adding a compound to at least one well containing test cells to form at least one compound well and adding a vehicle control to at least another well containing test cells to form at least one control well, measuring second impedances of the compound well and the control well and optionally determining second cell indices from the second impedances, determining the change in the impedance or cell index for the compound well and the one control well, comparing the change in impedance or cell index between the compound well and the control
    Type: Application
    Filed: August 4, 2005
    Publication date: March 9, 2006
    Inventors: Yama Abassi, Naichen Yu, Josephine Atienza, Xiao Xu, Xiabo Wang