Patents by Inventor Naidong Ye

Naidong Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for isolating ()-tofisopam
    Patent number: 7265106
    Abstract: (R)-tofisopam, substantially free of the (S)-enantiomer of tofisopam, is obtained by separating the enantiomers of tofisopam by chromatography employing a chiral separation medium comprising (i) (2S)-2-{(1S)[(3,5-dinitrophenyl)carbonylamino]phenylmethyl}-3,3-dimethylbutanoate, covalently bound to silica through an alkylene ester linkage or (ii) an amylose derivative of formula I: wherein each R1 and n are defined herein; the amylose derivative being coated on a porous inorganic carrier or a porous organic carrier.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: September 4, 2007
    Assignee: Vela Aquisition Corporation
    Inventors: Scott R. Perrin, Kimm B. Galbraith, Naidong Ye
  • Conversion process for 2,3-benzodiazepine enantiomers
    Publication number: 20060264421
    Abstract: Methods for the racemization of an enantiomer of a 2,3-benzodiazepine molecule into the corresponding racemic mixture under either basic or acidic conditions are described. Furthermore, the invention relates to the conversion of an enantiomer of tofisopam or its metabolites to the corresponding opposite enantiomer.
    Type: Application
    Filed: May 23, 2005
    Publication date: November 23, 2006
    Applicant: Vela Pharmaceuticals, Inc.
    Inventors: Yong Wei, Naidong Ye, Kimm Galbraith, Jianfeng Shi, Wuyi Wang, Yungen Xu, Mallikarjun Ravi
  • Method of isolating (R)-tofisopam
    Publication number: 20060128955
    Abstract: The present invention is directed to a process for the isolation of (R)-tofisopam with high enantiomeric purity and high overall yields from a mixture of tofisopam enantiomers by means of a non-steady state continuous chromatographic process.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 15, 2006
    Applicant: Vela Pharmaceuticals, Inc.
    Inventors: Scott Perrin, Naidong Ye, Kimm Galbraith, Wilhelm Hauck
  • Method for isolating (R)-tofisopam
    Publication number: 20040254174
    Abstract: (R)-tofisopam, substantially free of the (S)-enantiomer of tofisopam, is obtained by separating the enantiomers of tofisopam by chromatography employing a chiral separation medium comprising (i) (2S)-2-{(1S)[(3,5-dinitrophenyl)carbonylamino]phenylmethyl}-3,3-dimethylbutanoate, covalently bound to silica through an alkylene ester linkage or (ii) an amylose derivative of formula I: 1
    Type: Application
    Filed: May 7, 2004
    Publication date: December 16, 2004
    Applicant: Vela Pharmaceuticals, Inc.
    Inventors: Scott R. Perrin, Kimm B. Galbraith, Naidong Ye