Patents by Inventor Nakako Arao

Nakako Arao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microorganism, its product and utilization thereof
    Patent number: 7115721
    Abstract: There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl ?-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and ?-L-rhamnopyranoside produced thereby. This novel microorganism is a gram-negative bacillus isolated from soil and shows motility owing to polar flagellum. The ?-L-rhamnopyranoside, which is produced by culturing the microorganism under aerobic conditions at a culture temperature of 10 to 37° C. and at a medium pH of about 5 to 9 usually for about 1 to 7 days, is useful as a highly safe and stable whitening agent.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: October 3, 2006
    Assignees: Astellas Pharma Inc., Nagase & Co., Ltd,
    Inventors: Akira Nakagawa, Senji Takahashi, Toshitsugu Miyazaki, Yuuko Osanai, Kunio Kosaka, Koji Nagai, Nakako Arao, Kouichi Tanaka
  • Depsipeptide compound
    Patent number: 7098024
    Abstract: This invention relates to a novel compound which has a cytotoxic activity and TGF-? like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: August 29, 2006
    Assignee: Astellas Pharma Inc.
    Inventors: Koji Nagai, Nakako Arao, Kinya Souda, Kazuma Kamigiri, Masamichi Mori, Nobuaki Shindo, Haruo Seto, Kazuo Shin-Ya
  • Thiopeptide compounds
    Patent number: 7030085
    Abstract: A microorganism belonging to the genus Bacillus is cultured and thiopeptide compounds QN3323 and thiocillin I/II compounds are collected from the culture medium. The compounds are useful as drugs to treat infections caused by multidrug-resistant bacteria.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: April 18, 2006
    Assignees: Astellas Pharma INC, National Institute of Advanced Industrial Science and Technology
    Inventors: Kazuma Kamigiri, Masato Watanabe, Koji Nagai, Nakako Arao, Kenichi Suzumura, Ken-ichi Suzuki, Ryuichiro Kurane, Masakazu Yamaoka, Yasuhiro Kawano
  • Novel microorganism, its product and utilization thereof
    Publication number: 20050063927
    Abstract: There are provided a novel microorganism Enterobacter sp. B20 strain which produces (E)-4-(2-isocyanovinyl)phenyl ?-rhamnopyranoside having a favorable effect of inhibiting melanogenesis and ?-L-rhamnopyranoside produced thereby. This novel microorganism is a gram-negative bacillus isolated from soil and shows motility owing to polar flagellum. The ?-L-rhamnopyranoside, which is produced by culturing the microorganism under aerobic conditions at a culture temperature of 10 to 37° C. and at a medium pH of about 5 to 9 usually for about 1 to 7 days, is useful as a highly safe and stable whitening agent.
    Type: Application
    Filed: January 29, 2003
    Publication date: March 24, 2005
    Inventors: Akira Nakagawa, Senji Takahashi, Toshitsugu Miyazaki, Yuuko Osanai, Kunio Kosaka, Koji Nagai, Nakako Arao, Kouichi Tanaka
  • Thiopeptide compounds
    Publication number: 20040097702
    Abstract: A microorganism belonging to the genus Bacillus is cultured and novel thiopeptide compounds QN3323 and publicly known compounds thiocillin I/II, etc. are collected from the culture medium. Because of having a favorable antibacterial activity, these thiopeptide compounds are useful as drugs, in particuclar, remedies for infection with multidrug-resistant bacteria.
    Type: Application
    Filed: September 15, 2003
    Publication date: May 20, 2004
    Inventors: Kazuma Kamigiri, Masato Watanabe, Koji Nagai, Nakako Arao, Kenichi Suzumura, Ken-ichi Suzuki, Ryuichiro Kurane, Masakazu Yamaoka, Yasuhiro Kawano
  • Novel depsipeptide compound
    Publication number: 20040082054
    Abstract: This invention relates to a novel compound which has a cytotoxic activity and TGF-&bgr; like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.
    Type: Application
    Filed: October 15, 2003
    Publication date: April 29, 2004
    Applicant: YAMANOUCHI PHARMACEUTICAL CO., LTD.
    Inventors: Koji Nagai, Nakako Arao, Kinya Souda, Kazuma Kamigiri, Masamichi Mori, Nobuaki Shindo, Haruo Seto, Kazuo Shin-Ya
  • Depsipeptide compound
    Patent number: 6670326
    Abstract: This invention relates to a novel compound which has a cytotoxic activity and TGF-&bgr; like activity for human cancer cells and is useful as an antitumor agent and to a pharmaceutical composition which contains the same.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: December 30, 2003
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Koji Nagai, Nakako Arao, Kinya Souda, Kazuma Kamigiri, Masamichi Mori, Nobuaki Shindo, Haruo Seto, Kazuo Shin-Ya