Patents by Inventor Nakako MITSUHASHI

Nakako MITSUHASHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220348578
    Abstract: A crystalline form I of a compound represented by Formula (VII-1): having characteristic peaks appearing at lattice spacing (d) of 7.34, 5.66, 5.53, 5.30, 5.02, 4.66, 4.37, 4.28, 4.06, 3.68, 3.62, 3.47, 3.36, 3.30, 3.16, 3.11, 3.03, 2.99 and 2.50 ? in the powder X-ray diffraction pattern.
    Type: Application
    Filed: July 7, 2022
    Publication date: November 3, 2022
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI, Yumiko SAITO
  • Patent number: 11414417
    Abstract: A crystalline form I of a compound represented by Formula (VII-1): having characteristic peaks appearing at lattice spacing (d) of 7.34, 5.66, 5.53, 5.30, 5.02, 4.66, 4.37, 4.28, 4.06, 3.68, 3.62, 3.47, 3.36, 3.30, 3.16, 3.11, 3.03, 2.99 and 2.50 ? in the powder X-ray diffraction pattern.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: August 16, 2022
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi, Yumiko Saito
  • Publication number: 20200181143
    Abstract: A crystalline form I of a compound represented by Formula (VII-1): having characteristic peaks appearing at lattice spacing (d) of 7.34, 5.66, 5.53, 5.30, 5.02, 4.66, 4.37, 4.28, 4.06, 3.68, 3.62, 3.47, 3.36, 3.30, 3.16, 3.11, 3.03, 2.99 and 2.50 ? in the powder X-ray diffraction pattern.
    Type: Application
    Filed: February 18, 2020
    Publication date: June 11, 2020
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI, Yumiko SAITO
  • Patent number: 10604522
    Abstract: A process for producing a compound of the following Formula (VII-CR): The process involving providing a compound represented by the following Formula (VI): in a case where the R3ONHC(?O) side chain in the compound of the Formula (VI) has a protecting group, removing the protecting group from the compound of the Formula (VI) with an acid, and adding an ester-based poor solvent to the resultant reaction solution to precipitate the compound of Formula (VII-CR), wherein in the compounds of the Formulas (VII-CR) and (VI), R3 is a C1-6 alkyl or a heterocycle.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: March 31, 2020
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi, Yumiko Saito
  • Publication number: 20190031659
    Abstract: A process for producing a compound of the following Formula (VII-CR): The process involving providing a compound represented by the following Formula (VI): in a case where the R3ONHC(?O) side chain in the compound of the Formula (VI) has a protecting group, removing the protecting group from the compound of the Formula (VI) with an acid, and adding an ester-based poor solvent to the resultant reaction solution to precipitate the compound of Formula (VII-CR), wherein in the compounds of the Formulas (VII-CR) and (VI), R3 is a C1-6 alkyl or a heterocycle.
    Type: Application
    Filed: October 1, 2018
    Publication date: January 31, 2019
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI, Yumiko SAITO
  • Patent number: 10131665
    Abstract: A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same:
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: November 20, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi, Yumiko Saito
  • Patent number: 10000491
    Abstract: A process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof by carrying out the following steps: wherein P is an NH protecting group capable of being removed with acid; R1 is 2,5-dioxopyrrolidin-1-yl, 1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl, 1,3-dioxohexahydro-1H-isoindol-2(3H)-yl, or 3,5-dioxo-4-azatricyclo[5.2.1.02.6]dec-8-en-4-yl; R2 is hydrogen, ClCO— or Cl3COCO—; R3 is C1-6 alkyl or heterocyclyl, or forms a 3- to 7-membered heterocyclic ring together with the —O—NH— to which it is attached; and OBn is benzyloxy.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: June 19, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi
  • Patent number: 10000492
    Abstract: A process for producing a compound represented by a Formula (III), including reacting a compound of the following formula with a compound selected from the group consisting of 1-hydroxypyrrolidine-2,5-dione, 2-hydroxy-3a,4,7,7a-tetrahydro-1H-isoindol-1,3(2H)-dione, 2-hydroxyhexahydro-1H-isoindol-1,3(2H)-dione and 4-hydroxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione, carrying out a carbonylation to obtain a compound of the following formula removing the NH protecting group P and treating the resultant compound with a base to produce a compound represented by the following formula wherein OBn is benzyloxy and R2 is hydrogen, ClCO— or Cl3COCO—.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: June 19, 2018
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao Abe, Takeshi Furuuchi, Yoshiaki Sakamaki, Nakako Mitsuhashi
  • Publication number: 20170283415
    Abstract: A process for producing a compound represented by a Formula (III), including reacting a compound of the following formula with a compound selected from the group consisting of 1-hydroxypyrrolidine-2,5-dione, 2-hydroxy-3a,4,7,7a-tetrahydro-1H-isoindol-1,3(2H)-dione, 2-hydroxyhexahydro-1H-isoindol-1,3(2H)-dione and 4-hydroxy-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione, carrying out a carbonylation to obtain a compound of the following formula removing the NH protecting group P and treating the resultant compound with a base to produce a compound represented by the following formula wherein OBn is benzyloxy and R2 is hydrogen, ClCO— or Cl3COCO—.
    Type: Application
    Filed: June 5, 2017
    Publication date: October 5, 2017
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI
  • Publication number: 20160272641
    Abstract: A crystalline form of a diazabicyclooctane derivative represented by the following Formula (VII), and processes for producing the same:
    Type: Application
    Filed: October 8, 2014
    Publication date: September 22, 2016
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI, Yumiko SAITO
  • Publication number: 20160264573
    Abstract: A process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof by carrying out the following steps: wherein P is an NH protecting group capable of being removed with acid; R1 is 2,5-dioxopyrrolidin-1-yl, 1,3-dioxo-3a,4,7,7a-tetrahydro-1H-isoindol-2(3H)-yl, 1,3-dioxohexahydro-1H-isoindol-2(3H)-yl, or 3,5-dioxo-4-azatricyclo[5.2.1.02.6]dec-8-en-4-yl; R2 is hydrogen, ClCO— or Cl3COCO—; R3 is C1-6 alkyl or heterocyclyl, or forms a 3- to 7-membered heterocyclic ring together with the —O—NH— to which it is attached; and OBn is benzyloxy.
    Type: Application
    Filed: September 24, 2014
    Publication date: September 15, 2016
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takao ABE, Takeshi FURUUCHI, Yoshiaki SAKAMAKI, Nakako MITSUHASHI