Patents by Inventor Nalin Subasinghe

Nalin Subasinghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
    Publication number: 20040009995
    Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Nalin Subasinghe, Ehab Khalil, Kristi Leonard, Farah Ali, Heather Rae Hufnagel, Jeremy M. Travins, Shelley K. Ballentine, Kenneth T. Wilson, Maxwell D. Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen, M. Jonathan Rudolph, Hui Huang
  • Aminobenzenedicarboxylic acid-based combinatorial libraries
    Patent number: 6127191
    Abstract: The present invention provides a library of compounds, each comprised of a common aminobenzenedicarboxylic acid core structure (scaffold) that serves as a template for synthesizing approximately 10.sup.1 -10.sup.6 compounds which are analogs of the scaffold. The library is employed to study ligand binding by biological receptors, such as enzymes, G-protein coupled receptors and membrane channels. For example, certain individual compounds within the library selectively bind and inhibit the action of trypsin-like serine proteases. The present invention also relates to combinatorial synthetic methods for making such libraries of compounds. Additionally, the present invention relates to novel scaffold-modified solid supports, particularly scaffold-modified polymer resins and methods for preparing said resins.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: October 3, 2000
    Assignee: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Todd L. Graybill, Zhengdong Wu, Nalin Subasinghe, Cynthia L. Fedde, Joseph M. Salvino