Patents by Inventor Nallasivam Palanisamy
Nallasivam Palanisamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11015224Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.Type: GrantFiled: December 6, 2016Date of Patent: May 25, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Patent number: 9657350Abstract: Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent RNA fusions as diagnostic markers and clinical targets for leukemia.Type: GrantFiled: May 6, 2014Date of Patent: May 23, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Kojo Elenitoba-Johnson, Thirunavukkarasu Velusamy, Nallasivam Palanisamy, Anagh Sahasrabuddhe, Megan Lim, Arul Chinnaiyan
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Publication number: 20170081731Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.Type: ApplicationFiled: December 6, 2016Publication date: March 23, 2017Inventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Patent number: 9567644Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.Type: GrantFiled: January 5, 2015Date of Patent: February 14, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Publication number: 20150191795Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.Type: ApplicationFiled: January 5, 2015Publication date: July 9, 2015Inventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Patent number: 8945556Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.Type: GrantFiled: November 18, 2011Date of Patent: February 3, 2015Assignee: The Regents of The University of MichiganInventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Publication number: 20140364481Abstract: Provided herein are kits, compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent RNA fusions as diagnostic markers and clinical targets for leukemia.Type: ApplicationFiled: May 6, 2014Publication date: December 11, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Kojo Elenitoba-Johnson, Thirunavukkarasu Velusamy, Nallasivam Palanisamy, Anagh Sahasrabuddhe, Megan Lim, Arul Chinnaiyan
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Publication number: 20120142549Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer.Type: ApplicationFiled: November 18, 2011Publication date: June 7, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Arul Chinnaiyan, Nallasivam Palanisamy, Shanker Kalyana-Sundaram
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Patent number: 7964345Abstract: Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Methods utilizing probe sets with two and four colors are also described, as are automated methods for analyzing rearrangements.Type: GrantFiled: April 5, 2005Date of Patent: June 21, 2011Assignee: Cancer Genetics, Inc.Inventors: Nallasivam Palanisamy, Raju S. Chaganti
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Publication number: 20100285475Abstract: There is provided at least one isolated fused gene comprising at least one first gene and/or fragment thereof fused to at least one second gene and/or fragment thereof, wherein at least the first and/or the second gene, independently, is selected from the group consisting of: RCC2, CENPF, ARFGEF2, SULF2, MTAP, ATXN7, BCAS3, RPS6KB1, TMEM49, EAP30, a gene having the nucleotide sequence SEQ ID NO:1, and a gene having the nucleic acid SEQ ID NO:2, or a fragment thereof. There is also provided a diagnostic method and/or a kit for detecting the susceptibility, prognosis, and/or to tumour in a subject.Type: ApplicationFiled: October 22, 2007Publication date: November 11, 2010Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Nallasivam Palanisamy, Kalpana Ramnarayanan, Edison T. Liu
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Patent number: 7585964Abstract: Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Methods utilizing probe sets with two and four colors are also described, as are automated methods for analyzing rearrangements.Type: GrantFiled: May 14, 2002Date of Patent: September 8, 2009Assignee: Cancer Genetics, Inc.Inventors: Nallasivam Palanisamy, Raju S. Chaganti
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Publication number: 20070166749Abstract: Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Methods utilizing probe sets with two and four colors are also described, as are automated methods for analyzing rearrangements.Type: ApplicationFiled: March 12, 2007Publication date: July 19, 2007Applicant: Cancer Genetics, Inc.Inventors: Nallasivam Palanisamy, Raju Chaganti
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Publication number: 20050214842Abstract: Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Methods utilizing probe sets with two and four colors are also described, as are automated methods for analyzing rearrangements.Type: ApplicationFiled: April 5, 2005Publication date: September 29, 2005Applicant: Cancer Genetics, Inc.Inventors: Nallasivam Palanisamy, Raju Chaganti
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Publication number: 20020192692Abstract: Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to hybridize to chromosomes at regions outside known breakpoints, instead of spanning the breakpoint as with conventional FISH methods, and, in some instances, are further designed to bind to regions located outside the genes involved in the rearrangement. Methods utilizing probe sets with two and four colors are also described, as are automated methods for analyzing rearrangements.Type: ApplicationFiled: May 14, 2002Publication date: December 19, 2002Applicant: Cancer Genetics, Inc.Inventors: Nallasivam Palanisamy, Raju S. Chaganti