Patents by Inventor Nam Chul Ha
Nam Chul Ha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11510899Abstract: Provided is a method for treating a symptom of vibrio infection by using an RTX toxin production inhibitor comprising N-(4-oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenylprop-2-ynamide having derivatives thereof which can repress (prevent or treat) a symptom of vibrio infection by inhibiting RTX toxin production, other than directly killing vibrio bacteria, to not allow vibrio bacteria to have pathogenicity, and thereby can be an alternative to antibiotics that aim to kill bacteria themselves and thus fundamentally retain the problem of resistance incurrence.Type: GrantFiled: January 7, 2019Date of Patent: November 29, 2022Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Sang Ho Choi, Lak Shin Jeong, Ho Jae Han, Nam Chul Ha, Byoung Sik Kim, Kyung Ku Jang, Zee-Won Lee
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Publication number: 20220204985Abstract: The present disclosure relates to a composition for promoting plant growth containing an YxaL protein and a method for mass-producing an YxaL protein. The YxaL protein may be expressed constitutively and in large amounts in a recombinant transformed cell line. When the YxaL protein is applied to seed soaking treatment, root development is improved, and the expression of plant genes involved in root growth is improved in favor of plant growth. Thus, the YxaL protein may be effectively used to promote plant growth.Type: ApplicationFiled: October 10, 2019Publication date: June 30, 2022Inventors: Yong Hak KIM, Yun Hee CHOI, Jae Kyeong SONG, Nam Chul HA
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Patent number: 11322334Abstract: A grid sample production apparatus includes: a frame in which an internal space is formed; a grid unit which is vertically provided on an upper side of the frame, and grips a grid at a lower end; a filter unit which is provided to be movable inside the frame and selectively absorbs the protein liquid of the grid gripped at one end of the grid unit; a laser unit which is provided on one side of the filter unit; a screen unit which is disposed inside the frame and on which a diffraction image appears by the laser from the laser unit by being diffracted by the grid; and a liquid amount analysis unit which analyzes an illuminance of the diffraction image appeared on the screen unit and determines whether the protein liquid of the grid is disposed in an appropriate amount.Type: GrantFiled: July 1, 2019Date of Patent: May 3, 2022Assignee: XTEM BIOLAB CO., LTD.Inventors: Nam Chul Ha, Inseong Jo
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Publication number: 20210166912Abstract: A grid sample production apparatus includes: a frame in which an internal space is formed; a grid unit which is vertically provided on an upper side of the frame, and grips a grid at a lower end; a filter unit which is provided to be movable inside the frame and selectively absorbs the protein liquid of the grid gripped at one end of the grid unit; a laser unit which is provided on one side of the filter unit; a screen unit which is disposed inside the frame and on which a diffraction image appears by the laser from the laser unit by being diffracted by the grid; and a liquid amount analysis unit which analyzes an illuminance of the diffraction image appeared on the screen unit and determines whether the protein liquid of the grid is disposed in an appropriate amount.Type: ApplicationFiled: July 1, 2019Publication date: June 3, 2021Applicant: XTEM BIOLAB CO., LTD.Inventors: Nam Chul HA, Inseong JO
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Patent number: 10871474Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.Type: GrantFiled: November 17, 2017Date of Patent: December 22, 2020Assignee: BODITECH MED INC.Inventors: Byeong Chul Kim, Bong Suk Moon, Younghaeng Lee, Ju Hyoung Bang, Nam Chul Ha, Jae Un An
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Publication number: 20200237718Abstract: Provided is a method for treating a symptom of vibrio infection by using an RTX toxin production inhibitor comprising N-(4-oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenylprop-2-ynamide having derivatives thereof which can repress (prevent or treat) a symptom of vibrio infection by inhibiting RTX toxin production, other than directly killing vibrio bacteria, to not allow vibrio bacteria to have pathogenicity, and thereby can be an alternative to antibiotics that aim to kill bacteria themselves and thus fundamentally retain the problem of resistance incurrence.Type: ApplicationFiled: January 7, 2019Publication date: July 30, 2020Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATIONInventors: Sang Ho CHOI, Lak Shin JEONG, Ho Jae HAN, Nam Chul HA, Byoung Sik KIM, Kyung Ku JANG, Zee-Won LEE
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Patent number: 10670499Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.Type: GrantFiled: May 13, 2016Date of Patent: June 2, 2020Assignee: BODITECH MED INC.Inventors: Byeong Chul Kim, Bong Suk Moon, Younghaeng Lee, Ju Hyoung Bang, Nam Chul Ha, Jae Un An
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Publication number: 20180128715Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.Type: ApplicationFiled: May 13, 2016Publication date: May 10, 2018Applicant: BODITECH MED INC.Inventors: Byeong Chul KIM, Bong Suk MOON, Younghaeng LEE, Ju Hyoung BANG, Nam Chul HA, Jae Un AN
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Publication number: 20180074027Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.Type: ApplicationFiled: November 17, 2017Publication date: March 15, 2018Applicant: BODITECH MED INC.Inventors: Byeong Chul KIM, Bong Suk MOON, Younghaeng LEE, Ju Hyoung BANG, Nam Chul HA, Jae Un AN
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Patent number: 9400281Abstract: Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.Type: GrantFiled: December 31, 2013Date of Patent: July 26, 2016Assignees: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITYInventors: Bum Joon Park, Nam Chul Ha, Sun Hye Lee, Gyu Yong Song, Jee Hyun Lee
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Patent number: 9249153Abstract: Disclosed are a method for treating an aging-related disease and a method for screening a therapeutic agent for an aging-related disease. The method for treating an aging-related disease includes administering to a subject a progerin expression inhibitor as an active ingredient. The method for screening a therapeutic agent for an aging-related disease includes selecting a candidate drug inhibitory of progerin expression.Type: GrantFiled: March 19, 2012Date of Patent: February 2, 2016Assignees: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITYInventors: Bum Joon Park, Nam Chul Ha, Gyu Yong Song, Ji Hyun Lee, Su Jin Lee, Youn Sang Jung
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Publication number: 20140147866Abstract: Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.Type: ApplicationFiled: December 31, 2013Publication date: May 29, 2014Applicants: THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATIONInventors: Bum Joon PARK, Nam Chul Ha, Sun Hye Lee, Gyu Yong Song, Jee Hyun Lee
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Patent number: 8729230Abstract: The present invention provides novel proteins activating pro-phenoloxidase (pro-PO) system of Tenebrio molitor, genes encoding the same, methods of detecting bacterial infection in a sample using the proteins, and kits for detecting bacterial infection in a sample using the proteins. The present invention also provides a method of preparing a soluble linearized Lys-type pep-tidoglycan (SLPG), useful for a standard substance for the kit.Type: GrantFiled: February 4, 2008Date of Patent: May 20, 2014Assignee: Yhan CorporationInventors: Bok-Luel Lee, Ji-Won Park, Nam-Chul Ha, Chan-Hee Kim, Su-Jin Kim, Kyung-Baeg Roh
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Publication number: 20140039010Abstract: Disclosed are a method for treating an aging-related disease and a method for screening a therapeutic agent for an aging-related disease. The method for treating an aging-related disease includes administering to a subject a progerin expression inhibitor as an active ingredient. The method for screening a therapeutic agent for an aging-related disease includes selecting a candidate drug inhibitory of progerin expression.Type: ApplicationFiled: March 19, 2012Publication date: February 6, 2014Applicant: Pusan National University Industry-University Cooperation FoundationInventors: Bum Joon Park, Nam Chul Ha, Gyu Yong Song, Ji Hyun Lee, Su Jin Lee, Youn Sang Jung
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Publication number: 20120015960Abstract: Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or prevention of K-Ras mutant cancer, such as, pancreatic cancer, lung cancer, cholangioma, and colon cancer, of which diagnosis or treatment is not easy.Type: ApplicationFiled: November 23, 2009Publication date: January 19, 2012Applicants: The Industry & Academic Cooperation in Chungnam National University, Pusan National University Industry-University Cooperation FoundationInventors: Bum Joon Park, Nam Chul Ha, Sun Hye Lee, Gyu Yong Song, Jee Hyun Lee
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Patent number: 7915383Abstract: The present invention provides a separate and purified peptidoglycan-recognition protein having an amino acid sequence as set forth in SEQ ID NO: 1 and also a peptidoglycan detection kit comprising the separate and purified peptidoglycan-recognition protein.Type: GrantFiled: January 13, 2006Date of Patent: March 29, 2011Assignee: Yuhan CorporationInventors: Bok-Luel Lee, Ji-Won Park, Byung-Rok Je, Nam-Chul Ha
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Publication number: 20100317042Abstract: The present invention provides novel proteins activating pro-phenoloxidase (pro-PO) system of Tenebrio molitor, genes encoding the same, methods of detecting bacterial infection in a sample using the proteins, and kits for detecting bacterial infection in a sample using the proteins. The present invention also provides a method of preparing a soluble linearized Lys-type pep-tidoglycan (SLPG), useful for a standard substance for the kit.Type: ApplicationFiled: February 4, 2008Publication date: December 16, 2010Applicant: YUHAN CORPORATIONInventors: Bok-Luel Lee, Ji-Won Park, Nam-Chul Ha, Chan-Hee Kim, Su-Jin Kim, Kyung-Baeg Roh
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Publication number: 20080312408Abstract: Provided is a method of separating a peptidoglycan-recognition protein from the hemolymph of Tenebrio molitor larvae, the method including: (a) preparing an affinity chromatography column by packing a column with a resin bound with at least one synthetic peptidoglycan; (b) applying the hemolymph of Tenebrio molitor larvae to the affinity chromatography column; (c) applying a mobile phase to the affinity chromatography column to obtain a peptidoglycan-recognition protein-containing solution eluted from the affinity chromatography column; and (d) purifying a peptidoglycan-recognition protein from the eluted solution.Type: ApplicationFiled: January 13, 2006Publication date: December 18, 2008Applicant: YUHAN CORPORATIONInventors: Bok-Luel Lee, Ji-Won Park, Byung-Rok Je, Nam-Chul Ha
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Patent number: 6808909Abstract: The present invention relates to a thermostable enzyme with a 2.1 Å crystal structure of a propeller type comprising six external blades that encompass the outer boundary of the crystal and six internal calcium-binding sites that are embedded inside the above crystal. Each of the six blades comprises 4 or 5 anti-parallel &bgr;-strands, and the six calcium binding sites consist of 3 high-affinity calcium binding sites and 3 low-affinity binding sites, which are involved in the enzyme's thermostability and catalytic activity, respectively. The above-mentioned Ca2+ binding motifs are expected to be utilized in synthesizing highly thermostable proteins and the elucidation of active sites of an enzyme from a three-dimensional structure can help to design new enzymes having those sites with the aid of recent advanced technology of protein engineering.Type: GrantFiled: January 9, 2002Date of Patent: October 26, 2004Assignees: Korea Research Institute of Bioscience and Biotechnology, Daesung Microbiological Labs. Co.Inventors: Tae Kwang Oh, Nam Chul Ha, Byung Ha Oh
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Publication number: 20020142433Abstract: The present invention relates to a thermostable enzyme with a 2.1 Å crystal structure of a propeller type comprising six external blades that encompass the outer boundary of the crystal and six internal calcium-binding sites that are embedded inside the above crystal. Each of the six blades comprises 4 or 5 anti-parallel &bgr;-strands, and the six calcium binding sites consist of 3 high-affinity calcium binding sites and 3 low-affinity binding sites, which are involved in the enzyme's thermostability and catalytic activity, respectively. The above-mentioned Ca2+ binding motifs are expected to be utilized in synthesizing highly thermostable proteins and the elucidation of active sites of an enzyme from a three-dimensional structure can help to design new enzymes having those sites with the aid of recent advanced technology of protein engineering.Type: ApplicationFiled: January 9, 2002Publication date: October 3, 2002Inventors: Tae Kwang Oh, Byung Chul Oh, Nam Chul Ha, Yang Woong Choi, Dong Kyu Lee, Byung Ha Oh