Abstract: A medical device and method of using said medical device to remove a biopsy specimen from a patient. The device includes a series of retaining members, such as grooves or ridges protruding into the internal lumen of the medical device. The retaining members do not fully circumscribe the internal lumen. Upon rotation of the device, the retaining members engage the sample tissue received in the internal lumen, which improves the interference between the device and the tissue sample for extraction of the tissue sample from the patient. In some embodiments the grooves are angled to further improve interference between the device and the tissue sample. The medical may also include a biopsy sample ejector or ejector funnel and a cannula and/or a trocar with respective tips configured to optimize penetration of the device into the tissue with minimum patient trauma and enhanced reliability of obtaining a biopsy specimen.

Abstract: The method of making the e-vaping cartridge includes cutting at least one first hole through a first channel, sliding a housing over the first channel, the at least one first hole providing fluid communication between a first reservoir and a second reservoir, the first reservoir being defined between the housing and the first channel, where the second reservoir is defined between the first channel and a central passage traversing through the first channel. The method further includes inserting at least one first layer of absorbent material within the second reservoir, and positioning a heater and a wick in communication with the central passage. Distal ends of the wick contact the at least one first layer of absorbent material, where the heater is configured to vaporize a pre-vapor formulation that is communicated by the wick from the at least one first layer of absorbent material.

Abstract: A cartridge for an e-vaping device includes a housing extending along a longitudinal axis of the cartridge, and an outlet-end insert coupled to the outlet end of the housing. The housing at least partially encloses a pre-vapor formulation reservoir and a vapor generator of the cartridge and further channels light via internal reflection through an interior of the housing. The outlet-end insert includes an outlet in flow communication with the vapor generator, directs the vapor generated by the vapor generator out of the cartridge through the outlet, and further emits the light channeled through the interior of the housing. One or more properties of the light are controllable.

Abstract: In some aspects, the disclosure is directed to methods and systems for automatic machine learning through a combination of unsupervised and supervised machine learning from a large set of machine learning algorithms and feature selectors and transformers to generate a plurality of machine learning models, each associated with a particular combination of features and hyperparameters. Each machine learning model is trained and assessed to identify the best performing model based on one or more specified statistical measures. An application may be automatically constructed based on a selected model to process further input data.

Abstract: A cartridge for an e-vaping device includes a housing extending along a longitudinal axis of the cartridge, and an outlet-end insert coupled to the outlet end of the housing. The housing at least partially encloses a pre-vapor formulation reservoir and a vapor generator of the cartridge and further channels light via internal reflection through an interior of the housing. The outlet-end insert includes an outlet in flow communication with the vapor generator, directs the vapor generated by the vapor generator out of the cartridge through the outlet, and further emits the light channeled through the interior of the housing. One or more properties of the light are controllable.

Abstract: A cartridge for an e-vaping device includes a housing extending along a longitudinal axis of the cartridge, and an outlet-end insert coupled to the outlet end of the housing. The housing at least partially encloses a pre-vapor formulation reservoir and a vapor generator of the cartridge and further channels light via internal reflection through an interior of the housing. The outlet-end insert includes an outlet in flow communication with the vapor generator, directs the vapor generated by the vapor generator out of the cartridge through the outlet, and further emits the light channeled through the interior of the housing. One or more properties of the light are controllable.

Abstract: A cartridge for an e-vaping device includes a housing extending along a longitudinal axis of the cartridge, and an outlet-end insert coupled to the outlet end of the housing. The housing at least partially encloses a pre-vapor formulation reservoir and a vapor generator of the cartridge and further channels light via internal reflection through an interior of the housing. The outlet-end insert includes an outlet in flow communication with the vapor generator, directs the vapor generated by the vapor generator out of the cartridge through the outlet, and further emits the light channeled through the interior of the housing. One or more properties of the light are controllable.

Abstract: A method of forming a heater assembly of an e-vaping device includes bending a wire to form a first lobe and bending the wire to form a second lobe. The first lobe and the second lobe form a generally sinuously-shaped heater having a first set of lobes and a second set of lobe. A first apex of the first lobe is generally opposite a second apex of the second lobe. The method may also include curling the first set of lobes towards the second set of lobes to form a heater having a substantially tubular form. The heater defines an opening there through.

Abstract: The invention discloses a method for determining a nucleotide sequence of a nucleic acid segment present in a biological sample, comprising the steps of: a) generating a fluorescent image of the sample by a protocol comprising immunofluorescence detection of at least five different target proteins in the sample; b) selecting a region of interest of the sample by comparing the image to a predetermined criterion; c) removing a subsample from the region of interest, and; d) determining a nucleotide sequence of a nucleic acid segment present in the subsample.

Abstract: A method of forming a heater assembly of an e-vaping device includes bending a wire to form a first lobe and bending the wire to form a second lobe. The first lobe and the second lobe form a generally sinuously-shaped heater having a first set of lobes and a second set of lobe. A first apex of the first lobe is generally opposite a second apex of the second lobe. The method may also include curling the first set of lobes towards the second set of lobes to form a heater having a substantially tubular form. The heater defines an opening there through.

Abstract: A power supply assembly for an e-vaping device may include a coupling interface configured to couple with a cartridge to configure the e-vaping device to generate a vapor, a light-emitting device, and a light tube structure extending from the light-emitting device and through the coupling interface. The light tube structure may channel light emitted by the light-emitting device to emit the light into a reservoir of the cartridge to cause at least one portion of the cartridge to emit at least a portion of the channeled light to an external environment.

Abstract: The present disclosure relates, according to some embodiments, to methods and systems for impregnating wood with a polymer solution and products thereof. In some embodiments, the present disclosure relates to a method of processing a wood piece to generate a wood product, the method comprising: (a) placing the wood piece into a reactor having a chamber pressure of a vacuum environment; (b) exposing the wood piece to a polymer solution; (c) performing an iterative process where each cycle of the iterative process comprises a pressurizing period during which the chamber pressure is increased to an increased chamber pressure and a stabilizing period during which the chamber pressure is monitored to measure a chamber pressure decrease, if any; (d) when the decrease of chamber pressure during the stabilizing period is less than or equal to the certain threshold change, normalizing the reactor chamber to a normalized pressure; and (e) setting the wood piece to generate the wood product.

Abstract: The method of making the e-vaping cartridge includes cutting at least one first hole through a first channel, sliding a housing over the first channel, the at least one first hole providing fluid communication between a first reservoir and a second reservoir, the first reservoir being defined between the housing and the first channel, where the second reservoir is defined between the first channel and a central passage traversing through the first channel. The method further includes inserting at least one first layer of absorbent material within the second reservoir, and positioning a heater and a wick in communication with the central passage. Distal ends of the wick contact the at least one first layer of absorbent material, where the heater is configured to vaporize a pre-vapor formulation that is communicated by the wick from the at least one first layer of absorbent material.

Abstract: The e-vaping cartridge includes a housing, a first tube extending in a longitudinal direction within the housing, the first tube defining at least one first hole that provides fluid communication between a first annulus reservoir and a second annulus reservoir, the first annulus reservoir defined between the housing and the first tube, the second annulus reservoir defined between the first tube and a central passage traversing through the first tube. At least one first layer of absorbent material is positioned within the second annulus reservoir. A wick is in communication with the central passage, where distal ends of the wick contact the at least one first layer of absorbent material. A heater is configured to vaporize a pre-vapor formulation that is communicated by the wick from the at least one first layer of absorbent material. The device includes the cartridge.

Abstract: Methods are provided for modeling mobility based on one or more devices of the user. Methods may include: receiving at least a portion of a first mobility model from a first device, where the first mobility model may be established based on learning algorithms performed on the first device; updating a shared mobility model to become a first shared mobility model based on the at least a portion of the first mobility model; providing the first shared mobility model to the first device; receiving at least a portion of a second mobility model from a second device, where the second mobility model may be established based on learning algorithms performed on the second device; updating the first shared mobility model to become a second shared mobility model based on the at least a portion of the second mobility model; and providing the second shared mobility model to the second device.

Abstract: A cartridge for an e-vaping device may include a housing extending along a longitudinal axis of the cartridge, and an outlet-end insert coupled to the outlet end of the housing. The housing may at least partially enclose a pre-vapor formulation reservoir and a vapor generator of the cartridge and may further channel light via internal reflection through an interior of the housing. The outlet-end insert may include an outlet in flow communication with the vapor generator, may direct the vapor generated by the vapor generator out of the cartridge through the outlet, and may further emit the light channeled through the interior of the housing. One or more properties of the light may be controlled.

Abstract: The invention comprises methods of identifying and isolating spermatagonial stem cells in testicular tissue samples by the use of markers unique to spermatagonial stem cells. The invention defines and characterizes a unique testicular cellular niche wherein spermatagonial stem cells reside. The invention also comprises methods of identifying and isolating multipotent testicular stromal cells, on which spermatagonial stem cells can be cultured. Cultured spermatagonial stem cells, derived from prepubertal males or cancer patients can be utilized to generate viable spermatozoon or may be subsequently transplanted back into the donor to restore fertility.

Abstract: The present disclosure relates, according to some embodiments, to methods and systems for impregnating wood with a polymer solution and products thereof. In some embodiments, the present disclosure relates to a method of processing a wood piece to generate a wood product, the method comprising: (a) placing the wood piece into a reactor having a chamber pressure of a vacuum environment; (b) exposing the wood piece to a polymer solution; (c) performing an iterative process where each cycle of the iterative process comprises a pressurizing period during which the chamber pressure is increased to an increased chamber pressure and a stabilizing period during which the chamber pressure is monitored to measure a chamber pressure decrease, if any; (d) when the decrease of chamber pressure during the stabilizing period is less than or equal to the certain threshold change, normalizing the reactor chamber to a normalized pressure; and (e) setting the wood piece to generate the wood product.

Abstract: The e-vaping cartridge includes a housing, a first tube extending in a longitudinal direction within the housing, the first tube defining at least one first hole that provides fluid communication between a first annulus reservoir and a second annulus reservoir, the first annulus reservoir defined between the housing and the first tube, the second annulus reservoir defined between the first tube and a central passage traversing through the first tube. At least one first layer of absorbent material is positioned within the second annulus reservoir. A wick is in communication with the central passage, where distal ends of the wick contact the at least one first layer of absorbent material. A heater is configured to vaporize a pre-vapor formulation that is communicated by the wick from the at least one first layer of absorbent material. The device includes the cartridge.

Abstract: In one embodiment, the system includes one or more electrical components associated with turbomachinery, and the one or more electrical components are disposed within two or more interior compartments of an electrical enclosure. The system also includes a cooling system coupled to the electrical enclosure. The cooling system includes one or more air ducts configured to direct a cooling air to each interior compartment of the two or more interior compartments. The cooling system also includes a controller configured to route cooling air to each interior compartment via the one or more air ducts. The controller is configured to independently regulate a thermal environment for each interior compartment of the two or more interior compartments.