Patents by Inventor Namir Sioufi

Namir Sioufi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugates For Use In Hepatocyte Free Uptake Assays
    Publication number: 20110171730
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: December 21, 2010
    Publication date: July 14, 2011
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: C. Frank Bennett, Robert McKay, Brett P. Monia, Brenda F. Baker, Namir Sioufi
  • Conjugates for use in hepatocyte free uptake assays
    Patent number: 7884086
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: February 8, 2011
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: C. Frank Bennett, Robert McKay, Brett P. Monia, Brenda F. Baker, Namir Sioufi
  • MODULATION OF ACE2 EXPRESSION
    Publication number: 20070238681
    Abstract: Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
    Type: Application
    Filed: December 7, 2006
    Publication date: October 11, 2007
    Inventors: Kenneth Dobie, Susan Freier, Michael Buchmeier, Benjamin Neuman, C. Bennett, Namir Sioufi
  • Modulation of ace2 expression
    Publication number: 20070185044
    Abstract: Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
    Type: Application
    Filed: March 8, 2005
    Publication date: August 9, 2007
    Inventors: Kenneth Dobie, Susan Freier, Michael Buchmeier, Benjamin Neuman, C. Bennett, Namir Sioufi
  • Conjugates for use in hepatocyte free uptake assays
    Publication number: 20060084094
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: September 7, 2005
    Publication date: April 20, 2006
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker, Namir Sioufi, Richard Griffey, Balkrishen Bhat, Eric Swayze
  • Sequential delivery of oligomeric compounds
    Publication number: 20050260755
    Abstract: The present invention provides double stranded compositions that have a region that is complementary to a target nucleic acid. The targeting strand comprises linked ribofuranosyl nucleosides and the second strand comprises linked modified nucleosides that have 3?-endo conformational geometry. The strands can be linked together or separate and may contain additional groups. The present invention also provides methods of using the compositions for modulating gene expression.
    Type: Application
    Filed: April 6, 2005
    Publication date: November 24, 2005
    Applicant: ISIS Pharmaceuticals, inc.
    Inventors: Brenda Baker, Bryan Kraynack, Namir Sioufi
  • Hepatocyte free uptake assays
    Publication number: 20050221275
    Abstract: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits.
    Type: Application
    Filed: April 14, 2004
    Publication date: October 6, 2005
    Inventors: C. Bennett, Robert McKay, Brett Monia, Brenda Baker, Namir Sioufi