Abstract: Methods and devices for adding liquids to and washing a microfluidic element array are disclosed. The method and devices feature a microfluidic plate holder with a sloped wall for improved draining of liquid, a machine readable/writable identifier, plate leveling systems, liquid filling systems, a hydrophilic-liquid coating, and an automated washing station.

Abstract: A mobile terminal includes a body having a display unit for displaying at least visual information or a user input unit for inputting a control command on one surface of the display unit. The mobile terminal also includes an antenna pattern positioned near the display unit or the user input unit. The antenna pattern transmits or receives a wireless signal. The display unit or the user input unit is configured to transmit light therethrough from one surface of the body to an opposite surface of the body. The antenna pattern is formed at an end or side surface of the body that is transverse to the surface on which the display unit or user input unit is positioned and is positioned away from the display unit or the user input unit.

Abstract: A portable terminal comprises a ground portion mounted in a body of the portable terminal, and configured to form electrical ground of a circuit board which controls the portable terminal, a conductive member mounted to a case which forms appearance of the body, and formed of a conductive material, a first radiator electrically connected to the ground portion so as to be fed by the ground portion, and configured to transmit and receive radio electromagnetic waves, a second radiator formed of a conductive material, and connected to the conductive member so as to form an antenna pattern together with the ground portion and the conductive member, the antenna pattern consecutive with a feed point of the first radiator, and a connection member configured to electrically connect edges of the ground portion to the conductive member such that the first radiator and the antenna pattern form a dipole antenna.

Abstract: The present invention relates to bio-molecule resistant surfaces for use in assays, particularly in assay devices such as arrays and microfluidic devices. The biomolecule resistant surface of the present invention are prepared by coating a substrate with hydrophilic terminated alkoxysilanes having formula (A): wherein R is an alkyl group of a size that allows for sufficient hydrolysis and n is 1, 2 or 3; R1 is a hydrophilic moiety; LC is a C1 to a C10 linker chain consisting of a group selected from alkyl, aryl, alkaryl and aralkyl and m is 1, 2, or 3; R2 is a C1 to a C7 alkyl group and x is 0, 1, or 2; and m+n+x is equal to 4.

Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame.

Abstract: Methods for stably associating a polyelectrolyte coating or film to a substrate surface, as well as the coated substrates produced thereby, are disclosed herein. In the subject methods, substrate surfaces are coated with a polyelectrolyte, and the coated substrate surfaces are treated with a bifunctional molecule under conditions sufficient to stably associate the film to the array surface. The subject methods find use in a variety of different applications, including the production of mircoarrarys.

Abstract: The present invention relates to bio-molecule resistant surfaces for use in assays, particularly in assay devices such as arrays and microfluidic devices.

Abstract: A method for depositing a volume of fluid relative to a surface to produce a droplet relative to the surface comprising the steps of forming a bolus of liquid relative to a dispensing member, causing the bolus of liquid to make contact with a surface thereby forming a bridge of liquid between the dispensing member and the surface, and retracting only a portion of the bolus of liquid to break the bridge of liquid between the dispensing member and the surface thereby depositing a droplet on the surface. A volume of a droplet can be adjusted by forming a bridge of liquid between a dispensing member and a surface that includes an initial droplet and breaking the bridge of liquid while leaving a remaining droplet of a different volume than the initial droplet.

Abstract: Methods of producing ligand arrays, e.g., polypeptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same, are provided. In the subject methods, a substrate having a surface displaying olefinic functional groups, e.g., olefin groups having a single site of unsaturation, are modified such that the olefinic functional groups are converted to ligand reactive functional groups. The resultant substrate is then contacted with ligands, e.g., via deposition of each different ligand onto a different region of the surface, resulting in covalent attachment of the contacted ligand to the surface via reaction with the ligand reactive functional groups. Ligand arrays produced via the subject methods demonstrate a number of desirable properties, e.g., nucleic acid arrays produced by the subject methods provide high signal intensity with low background in nucleic acid hybridization assays, etc.

Abstract: Methods for stably associating a polyelectrolyte coating or film to a substrate surface, as well as the coated substrates produced thereby, are disclosed herein. In the subject methods, substrate surfaces are coated with a polyelectrolyte, and the coated substrate surfaces are treated with a bifunctional molecule under conditions sufficient to stably associate the film to the array surface. The subject methods find use in a variety of different applications, including the production of mircoarrarys.