Patents by Inventor Nan-Sook Lee

Nan-Sook Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEM AND METHOD FOR DETERMINING TUMOR INVASIVENESS
    Publication number: 20200363399
    Abstract: A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.
    Type: Application
    Filed: December 5, 2019
    Publication date: November 19, 2020
    Inventors: Robert H. Chow, Jae Youn Hwang, Nan Sook Lee, K. Kirk Shung, Andrew C. Weitz
  • METHODS FOR TREATING AND ASSESSING TUMOR INVASION AND METASTASIS
    Publication number: 20180148789
    Abstract: Provided herein are methods, such as diagnostic methods, for evaluating a tissue sample, such as a biopsy or cytology specimen of a subject to determine a likelihood of metastasis, a risk of tumor or cancer occurrence, or combinations thereof and provided herein are methods, such as a screening method, for determining the efficacy of a drug in reducing cell invasiveness. Also provided are methods of treatment, drugs, primers, and kits.
    Type: Application
    Filed: December 1, 2015
    Publication date: May 31, 2018
    Inventors: Andrew C. WEITZ, Nan Sook LEE, Robert H. CHOW
  • SYSTEM AND METHOD FOR DETERMINING TUMOR INVASIVENESS
    Publication number: 20180143180
    Abstract: A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.
    Type: Application
    Filed: June 7, 2017
    Publication date: May 24, 2018
    Inventors: Robert H. CHOW, Jae Youn HWANG, Nan Sook LEE, K. Kirk SHUNG, Andrew C. WEITZ
  • Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
    Patent number: 9181584
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 10, 2015
    Assignee: CITY OF HOPE
    Inventors: John J. Rossi, Nan-Sook Lee
  • METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES
    Publication number: 20150118682
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Application
    Filed: January 6, 2015
    Publication date: April 30, 2015
    Applicant: CITY OF HOPE
    Inventors: John J. ROSSI, Nan-Sook LEE
  • Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
    Patent number: 8927519
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: January 6, 2015
    Assignee: City of Hope
    Inventors: John J. Rossi, Nan-Sook Lee
  • METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES
    Publication number: 20140206751
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Application
    Filed: January 27, 2014
    Publication date: July 24, 2014
    Applicant: CITY OF HOPE
    Inventors: John J. ROSSI, Nan-Sook LEE
  • SYSTEM AND METHOD FOR DETERMINING TUMOR INVASIVENESS
    Publication number: 20140087411
    Abstract: A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.
    Type: Application
    Filed: September 27, 2013
    Publication date: March 27, 2014
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Andrew C. Weitz, Nan Sook Lee, Jae Youn Hwang, Robert H. Chow, K. Kirk Shung
  • Adenoviral VA1 Pol III expression system for RNAi expression
    Patent number: 8299045
    Abstract: An adenoviral VA1 Pol III expression system for RNAi expression is provided.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: October 30, 2012
    Assignee: City of Hope
    Inventors: John J. Rossi, Nan-Sook Lee
  • METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES
    Publication number: 20120095080
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Application
    Filed: December 13, 2011
    Publication date: April 19, 2012
    Applicant: CITY OF HOPE
    Inventors: John J. ROSSI, Nan-Sook LEE
  • ADENOVIRAL VA1 POL III EXPRESSION SYSTEM FOR RNAI EXPRESSION
    Publication number: 20120058522
    Abstract: An adenoviral VA1 Pol III expression system for RNAi expression is provided.
    Type: Application
    Filed: August 25, 2011
    Publication date: March 8, 2012
    Applicant: CITY OF HOPE
    Inventors: John J. ROSSI, Nan-Sook LEE
  • Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
    Patent number: 8106181
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: January 31, 2012
    Assignee: City of Hope
    Inventors: John J. Rossi, Nan-Sook Lee
  • Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
    Patent number: 8076071
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: December 13, 2011
    Assignee: City of Hope
    Inventors: John J. Rossi, Nan-Sook Lee
  • Adenoviral VA1 Pol III promoter system for RNAi expression
    Patent number: 8017759
    Abstract: An adenoviral VA1 Pol III expression system for RNAi expression is provided.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: September 13, 2011
    Assignee: City of Hope
    Inventors: John J. Rossi, Nan-Sook Lee
  • METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES
    Publication number: 20110003307
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Application
    Filed: September 14, 2010
    Publication date: January 6, 2011
    Applicant: CITY OF HOPE
    Inventors: John J. ROSSI, Nan-Sook LEE
  • Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
    Patent number: 7820632
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: October 26, 2010
    Assignee: City Of Hope
    Inventors: John J. Rossi, Nan-Sook Lee
  • METHODS FOR PRODUCING INTERFERING RNA MOLECULES IN MAMMALIAN CELLS AND THERAPEUTIC USES FOR SUCH MOLECULES
    Publication number: 20100184207
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Application
    Filed: February 22, 2010
    Publication date: July 22, 2010
    Applicant: CITY OF HOPE
    Inventors: John J. ROSSI, Nan-Sook LEE
  • Adenoviral VA1 Pol III promoter system for RNAi expression
    Publication number: 20050074887
    Abstract: An adenoviral VA1 Pol III expression system for RNAi expression is provided.
    Type: Application
    Filed: July 30, 2003
    Publication date: April 7, 2005
    Inventors: John Rossi, Nan-Sook Lee
  • Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
    Publication number: 20040096843
    Abstract: Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided.
    Type: Application
    Filed: February 13, 2003
    Publication date: May 20, 2004
    Inventors: John J. Rossi, Nan-Sook Lee