Abstract: A knob structure for adjusting a sound parameter is provided, which includes a knob, an encoder, an interference component and a switching module. The knob has a shaft portion and an internal teeth portion. The encoder is connected to the shaft portion of the knob, in which the encoder includes a turntable and a bottom plate. The turntable has one or more protrusions in contact with the bottom plate. When the knob is rotated to rotate the turntable of the encoder, the one or more protrusions rub against the bottom plate. The interference component has a first end adjacent to the internal teeth portion of the knob. The switching module is configured to make the first end of the interference component be in contact with or moved away from the internal teeth portion of the knob. A headphone including the knob structure is also provided.

Abstract: A roller module includes a scroll wheel, a magnetization member, a swinging element and a pole-reversible magnetic element. The magnetization member is synchronously rotated with the scroll wheel. The swinging element includes a pivotal part, a first magnetic element and a second magnetic element. The first magnetic element and the second magnetic element are movable by using the pivotal part as a rotation center. The pole-reversible magnetic element and the first magnetic element interact with each other. Consequently, the second magnetic element is close to or away from the magnetization member.

Abstract: The invention relates to methods of detecting nucleic acids, including methods of detecting one or more target nucleic acid sequences in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support or suspending cells are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. The invention further relates to methods to improve probe hybridization specificity and their application in genotyping. The invention also relates to in situ detection of mis-joined nucleic acid sequences. The invention relates to reducing false positive signals and improve signal-to-background ratio in hybridization-based nucleic acid detection assay. The invention further relates to method to improve specificity in hybridization based nucleic acid using co-location probes. Compositions, tissue slides, sample of suspended cells, kits, and systems related to the methods are also described.

Abstract: The invention relates to methods of in situ detection of a nucleic acid variation of a target nucleic acid in a sample, including single nucleotide variations, multi-nucleotide variations or splice sites. The method can comprise the steps of contacting the sample with a probe that detects the nucleic acid variation or splice site and a neighbor probe; contacting the sample with pre-amplifiers that bind to the nucleic acid variation probe or splice site probe and neighbor probe, respectively; contacting the sample with a collaboration amplifier that binds to the pre-amplifiers; and contacting the sample with a label probe system, wherein hybridization of the components forms a signal generating complex (SGC) comprising a target nucleic acid with the nucleic acid variation or splice site, the probes and amplifiers; and detecting in situ signal from the SGC on the sample.

Abstract: A key structure includes a keycap, a connecting member, a fixing member, a light emitter and a light receiver. The connecting member is connected to an inner top surface of the keycap and extends downwards, and the connecting member has a first opening through the connecting member. The fixing member has a second opening through the fixing member, in which when the keycap is initially pressed and then continues to be pressed, the keycap moves in a direction, and the connecting member moves with the keycap, and an overlapping region defined by the first opening and the second opening gradually becomes larger or smaller. The light emitter is laterally adjacent to the second opening of the fixing member. The light receiver is laterally adjacent to the first opening of the connecting member.

Abstract: A wheel control mechanism includes a support base, a wheel module, a first magnetic module and a second magnetic module. The wheel module, the first magnetic module and the second magnetic module are installed on the support base. The first magnetic module generates a magnetic attractive force to attract a metal ratchet of the wheel module. By adjusting the position of the second magnetic module relative to the first magnetic module, the strength of the magnetic attractive force is changed. Consequently, the rotation of the wheel module results in a tactile feel or does not result in the tactile feel.

Abstract: A mouse device includes a casing and a roller module. The roller module is disposed within the casing. The roller module includes a scroll wheel, a magnetic ratchet, a supporting element and a permanent magnet. The scroll wheel includes a concave structure. The magnetic ratchet is disposed within the concave structure of the scroll wheel. While the scroll wheel is rotated, the magnetic ratchet is correspondingly rotated. The magnetic ratchet includes a ratchet frame and plural tooth structures. The plural tooth structures are discretely arranged on an inner surface of the ratchet frame. While the magnetic ratchet is rotated with the scroll wheel, the plural tooth structures of the magnetic ratchet are sequentially transferred through a region over the permanent magnet, and a magnetic attractive force between the corresponding tooth structure and the permanent magnet is generated.

Abstract: A wheel control mechanism includes a support base, a wheel module, a first magnetic module and a second magnetic module. The wheel module, the first magnetic module and the second magnetic module are installed on the support base. The first magnetic module generates a magnetic attractive force to attract a metal ratchet of the wheel module. By adjusting the position of the second magnetic module relative to the first magnetic module, the strength of the magnetic attractive force is changed. Consequently, the rotation of the wheel module results in a tactile feel or does not result in the tactile feel.

Abstract: A control device is provided. A key structure of the control device includes a keycap, an optical film layer and a membrane switch. A protrusion structure is formed on the optical film layer or the membrane switch. When the keycap is pressed down by the user, the arrangement of the protrusion structure can facilitate the user to trigger the underlying membrane switch more precisely.

Abstract: A mouse device includes a roller module. The roller module includes a base member, a scroll wheel, a magnetic conductor, a swingable arm, a driving motor and an actuating element. The scroll wheel is installed on the base member. The magnetic conductor is located beside the scroll wheel. When the scroll wheel is rotated, the magnetic conductor is correspondingly rotated. The swingable arm is installed on the base member. The swingable arm includes a magnetic element. The swingable arm is swingable relative to the magnetic conductor. When the swingable arm is swung to a first position, the magnetic element is aligned with the magnetic conductor. Consequently, a magnetic attraction force between the magnetic element and the magnetic conductor is generated. When the swingable arm is swung to a second position, the magnetic attraction force between the magnetic element and the magnetic conductor is eliminated.

Abstract: The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.

Abstract: The present invention belongs to the field of biomedicines, relates to a drug for treating tumors, and provides use of an anti-PD-L1 antibody or a pharmaceutical composition thereof in preparation of a drug for treating endometrial cancer. Also provided is use of the anti-PD-L1 antibody or the pharmaceutical composition thereof in preparation of a drug for treating a MSI-H and/or dMMR tumor. In addition, also provided is use of a pharmaceutical combination of the anti-PD-L1 antibody and Anlotinib or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof in preparation of a drug for treating endometrial cancer.

Abstract: The present application relates to the field of biomedicine, and relates to a combined medication for treating soft tissue sarcoma. The combined medication comprises an anti-PD-L1 antibody and anlotinib or a pharmaceutically acceptable salt thereof. In addition, further provided is a pharmaceutical composition comprising the anti-PD-L1 antibody and anlotinib or the pharmaceutically acceptable salt thereof, or the use of the pharmaceutical composition in preparation of a medication for treating soft tissue sarcoma.

Abstract: A control device is provided. A membrane switch of the control device is specially designed. A cured ink member is formed on a surface the upper film layer facing the lower film layer or a surface of the lower film layer facing the upper film layer by using a UV printing process. Due to the ink member, a specified gap or distance between the upper film layer and the lower film layer can be maintained when they are not contacted with each other or when the membrane switch is not triggered.

Abstract: A control device is provided. A key structure of the control device includes a keycap, an optical film layer and a membrane switch. A protrusion structure is formed on the optical film layer or the membrane switch. When the keycap is pressed down by the user, the arrangement of the protrusion structure can facilitate the user to trigger the underlying membrane switch more precisely.

Abstract: A control device is provided. A membrane switch of the control device is specially designed. A cured ink member is formed on a surface the upper film layer facing the lower film layer or a surface of the lower film layer facing the upper film layer by using a UV printing process. Due to the ink member, a specified gap or distance between the upper film layer and the lower film layer can be maintained when they are not contacted with each other or when the membrane switch is not triggered.

Abstract: The present disclosure relates to the technical field of biomedicine, in particular to use of advanced platelet-rich fibrin (A-PRF) in preparing a medicament for the treatment of diabetic foot ulcer. The A-PRF provided by the present disclosure has a loose reticular fibrin structure, can be rich in more platelets and leukocytes, can release a plurality of growth factors and cytokines more persistently, and is more beneficial to tissue regeneration and wound repair. The medicament prepared from the A-PRF shortens the healing period of the diabetic foot ulcer, improves the healing rate, and has an excellent treatment effect and high safety.

Abstract: A mouse device includes a wheel control mechanism and a control unit. The control unit is electrically connected with a magnetic force module and a rotating speed detector of the wheel control mechanism. Under control of the control unit, a first direction current or a second direction current is selectively provided to drive the magnetic force module. The flowing directions of the first direction current and the second direction current are opposite. Consequently, the rotating mode of the wheel control mechanism can be switched between different modes.

Abstract: A dynamic data transmission format adjustment method is provided. Firstly, a peripheral device raw input data is acquired from a device main body of a wireless peripheral device. Then, the peripheral device raw input data is converted into a variable-bit-length peripheral device transmission data according to a dynamic data transmission format conversion rule. Then, a network transmission packet containing the variable-bit-length peripheral device transmission data is generated, and the network transmission packet is transmitted to a wireless receiver of the wireless peripheral device. Then, the variable-bit-length peripheral device transmission data in the network transmission packet is converted and restored into a fixed-bit-length peripheral device transmission data according to the dynamic data transmission format conversion rule. Then, the fixed-bit-length peripheral device transmission data is transmitted from the wireless receiver to a computer host.

Abstract: A roller module includes a supporting seat, a scroll wheel, a linkage rod, a torsion spring, a first magnet, a second magnet and a coil. The scroll wheel is installed on the supporting seat. The linkage rod includes a fulcrum segment, a resisting segment and an effort segment. The torsion spring is connected with the resisting segment. The first magnet is arranged between the second magnet and the effort segment. The coil is arranged around the second magnet. When the roller module is in a tactile mode, the first magnet and the second magnet are close to each other, and the torsion spring exerts a pulling force on the resisting segment. Consequently, the resisting segment is contacted with a toothed region of the scroll wheel. When the roller module is in a non-tactile mode, the resisting segment is moved away from the toothed region.