Abstract: A satellite communication system that combines the benefits of Geosynchronous Equatorial Orbit (GEO) and Non-geostationary (NGSO) satellite systems into a GEO-NGSO hybrid satellite system. The hybrid system allows for various uses, such as, a NGSO-GEO-NGSO handoff, a GEO-NGSO-GEO handoff, and/or a multi-transport operation utilizing both the GEO and NGSO satellites. Based on the path delay differences of the GEO and NGSO satellites, the system may create a data buffer to ensure no data loss.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A piston pump group for a brake system and a control method thereof are provided, and the piston pump group includes: a piston, a pump body provided with an operating chamber, and a transmission mechanism used for driving the piston to move in the operating chamber, where the transmission mechanism includes a lead screw transmission assembly, a follower, and a planetary gear assembly used for transmitting power to the lead screw transmission assembly, the follower is fixedly connected to the piston, the lead screw transmission assembly is used for driving the follower to move relative to the operating chamber, and a limiting member used for limiting the movement of the follower is disposed between the lead screw transmission assembly and the follower.

Abstract: A wheel control mechanism includes a support base, a wheel module, a first magnetic module and a second magnetic module. The wheel module, the first magnetic module and the second magnetic module are installed on the support base. The first magnetic module generates a magnetic attractive force to attract a metal ratchet of the wheel module. By adjusting the position of the second magnetic module relative to the first magnetic module, the strength of the magnetic attractive force is changed. Consequently, the rotation of the wheel module results in a tactile feel or does not result in the tactile feel.

Abstract: A control device is provided. A key structure of the control device includes a keycap, an optical film layer and a membrane switch. A protrusion structure is formed on the optical film layer or the membrane switch. When the keycap is pressed down by the user, the arrangement of the protrusion structure can facilitate the user to trigger the underlying membrane switch more precisely.

Abstract: A mouse device includes a roller module. The roller module includes a base member, a scroll wheel, a magnetic conductor, a swingable arm, a driving motor and an actuating element. The scroll wheel is installed on the base member. The magnetic conductor is located beside the scroll wheel. When the scroll wheel is rotated, the magnetic conductor is correspondingly rotated. The swingable arm is installed on the base member. The swingable arm includes a magnetic element. The swingable arm is swingable relative to the magnetic conductor. When the swingable arm is swung to a first position, the magnetic element is aligned with the magnetic conductor. Consequently, a magnetic attraction force between the magnetic element and the magnetic conductor is generated. When the swingable arm is swung to a second position, the magnetic attraction force between the magnetic element and the magnetic conductor is eliminated.

Abstract: The present invention relates to detection of nucleic acids and provides a composition comprising a Signal Generating Complex, wherein the composition comprises: (A) a pair of target probes (TPs), wherein a first TP of the pair of TPs comprises a nucleic acid sequence comprising two segments; (B) a pair of base PPAs comprising the first and second base PPAs, wherein the first base PPA comprises a nucleic acid sequence comprising three segments; (C) a set of extension PPAs comprising the first and second extension PPAs, wherein the first extension PPA comprises a nucleic acid sequence comprising two segments; (D) a plurality of pre-amplifiers (PAs), wherein the PAs comprise a nucleic acid sequence comprising three segments; (E) a plurality of amplifiers (AMPs), wherein the AMPs comprise a nucleic acid sequence comprising two segments; and (F) a plurality of label probes (LPs), wherein the LPs comprise a nucleic acid sequence comprising two segments.

Abstract: The present invention belongs to the field of biomedicines, relates to a drug for treating tumors, and provides use of an anti-PD-L1 antibody or a pharmaceutical composition thereof in preparation of a drug for treating endometrial cancer. Also provided is use of the anti-PD-L1 antibody or the pharmaceutical composition thereof in preparation of a drug for treating a MSI-H and/or dMMR tumor. In addition, also provided is use of a pharmaceutical combination of the anti-PD-L1 antibody and Anlotinib or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition thereof in preparation of a drug for treating endometrial cancer.

Abstract: The present application relates to the field of biomedicine, and relates to a combined medication for treating soft tissue sarcoma. The combined medication comprises an anti-PD-L1 antibody and anlotinib or a pharmaceutically acceptable salt thereof. In addition, further provided is a pharmaceutical composition comprising the anti-PD-L1 antibody and anlotinib or the pharmaceutically acceptable salt thereof, or the use of the pharmaceutical composition in preparation of a medication for treating soft tissue sarcoma.

Abstract: A control device is provided. A membrane switch of the control device is specially designed. A cured ink member is formed on a surface the upper film layer facing the lower film layer or a surface of the lower film layer facing the upper film layer by using a UV printing process. Due to the ink member, a specified gap or distance between the upper film layer and the lower film layer can be maintained when they are not contacted with each other or when the membrane switch is not triggered.

Abstract: A control device is provided. A key structure of the control device includes a keycap, an optical film layer and a membrane switch. A protrusion structure is formed on the optical film layer or the membrane switch. When the keycap is pressed down by the user, the arrangement of the protrusion structure can facilitate the user to trigger the underlying membrane switch more precisely.

Abstract: A control device is provided. A membrane switch of the control device is specially designed. A cured ink member is formed on a surface the upper film layer facing the lower film layer or a surface of the lower film layer facing the upper film layer by using a UV printing process. Due to the ink member, a specified gap or distance between the upper film layer and the lower film layer can be maintained when they are not contacted with each other or when the membrane switch is not triggered.

Abstract: The present disclosure relates to the technical field of biomedicine, in particular to use of advanced platelet-rich fibrin (A-PRF) in preparing a medicament for the treatment of diabetic foot ulcer. The A-PRF provided by the present disclosure has a loose reticular fibrin structure, can be rich in more platelets and leukocytes, can release a plurality of growth factors and cytokines more persistently, and is more beneficial to tissue regeneration and wound repair. The medicament prepared from the A-PRF shortens the healing period of the diabetic foot ulcer, improves the healing rate, and has an excellent treatment effect and high safety.

Abstract: A mouse device includes a wheel control mechanism and a control unit. The control unit is electrically connected with a magnetic force module and a rotating speed detector of the wheel control mechanism. Under control of the control unit, a first direction current or a second direction current is selectively provided to drive the magnetic force module. The flowing directions of the first direction current and the second direction current are opposite. Consequently, the rotating mode of the wheel control mechanism can be switched between different modes.

Abstract: A dynamic data transmission format adjustment method is provided. Firstly, a peripheral device raw input data is acquired from a device main body of a wireless peripheral device. Then, the peripheral device raw input data is converted into a variable-bit-length peripheral device transmission data according to a dynamic data transmission format conversion rule. Then, a network transmission packet containing the variable-bit-length peripheral device transmission data is generated, and the network transmission packet is transmitted to a wireless receiver of the wireless peripheral device. Then, the variable-bit-length peripheral device transmission data in the network transmission packet is converted and restored into a fixed-bit-length peripheral device transmission data according to the dynamic data transmission format conversion rule. Then, the fixed-bit-length peripheral device transmission data is transmitted from the wireless receiver to a computer host.

Abstract: A roller module includes a supporting seat, a scroll wheel, a linkage rod, a torsion spring, a first magnet, a second magnet and a coil. The scroll wheel is installed on the supporting seat. The linkage rod includes a fulcrum segment, a resisting segment and an effort segment. The torsion spring is connected with the resisting segment. The first magnet is arranged between the second magnet and the effort segment. The coil is arranged around the second magnet. When the roller module is in a tactile mode, the first magnet and the second magnet are close to each other, and the torsion spring exerts a pulling force on the resisting segment. Consequently, the resisting segment is contacted with a toothed region of the scroll wheel. When the roller module is in a non-tactile mode, the resisting segment is moved away from the toothed region.

Abstract: A wireless input system includes a first computer, a second computer, a first-mode wireless connection device, a first input device and a second input device. When the first-mode wireless connection between the first input device and the first-mode wireless connection device is established and the first-mode wireless connection between the second input device and the first-mode wireless connection device is established, the first input device and the second input device can be operated to control the first computer. When the second-mode wireless connection between the first input device and the second computer is established, the second input device can follow the first input device to perform a connection switching operation. Consequently, the second-mode wireless connection between the second input device and the second computer is established.

Abstract: A function parameter switching memory circuit for a peripheral device is provided. The peripheral device includes a function parameter switching memory circuit, a power management device and an optical sensor. The function parameter switching memory circuit includes a function parameter switching key and a simulation control circuit. The function parameter switching key generates and outputs a physical switch signal in response to a switching trigger action of a user. The simulation control circuit generates a virtual switch signal to the optical sensor. The simulation control circuit analyzes the physical switch signal to memorize a switched-and-set function parameter storage value. The simulation control circuit generates the virtual switch signal according to one of the physical switch signal and the switched-and-set function parameter storage value. The optical sensor performs a function parameter switching process according to the virtual switch signal.

Abstract: The present application relates to the field of biomedicine, and relates to a combined pharmaceutical composition for treating biliary tract tumor, liver cancer, triple negative breast cancer or lung cancer. The combined pharmaceutical composition comprises an anti-PD-L1 antibody and anlotinib, and has good anti-biliary tract tumor, liver cancer, triple negative breast cancer or lung cancer activity.

Abstract: The invention relates to methods of in situ detection of a nucleic acid variation of a target nucleic acid in a sample, including single nucleotide variations, multi-nucleotide variations or splice sites. The method can comprise the steps of contacting the sample with a probe that detects the nucleic acid variation or splice site and a neighbor probe; contacting the sample with pre-amplifiers that bind to the nucleic acid variation probe or splice site probe and neighbor probe, respectively; contacting the sample with a collaboration amplifier that binds to the pre-amplifiers; and contacting the sample with a label probe system, wherein hybridization of the components forms a signal generating complex (SGC) comprising a target nucleic acid with the nucleic acid variation or splice site, the probes and amplifiers; and detecting in situ signal from the SGC on the sample.