Abstract: A method of determining a molecular descriptor of absorption for a candidate compound is disclosed. The method includes: providing a test solution comprising one or more candidate compounds; contacting the test solution with a simulated biological membrane to partition the one or more candidate compounds into the membrane detecting the presence or amount of the one or more candidate compound in the membrane at one or more permeation times; and determining a molecular descriptor of absorption using the presence or amount of the one or more candidate compound in the membrane at the one or more permeation times. In one aspect the invention provides a skin-imitating membrane, and one or more percutaneous absorption parameters are determined. In another aspect the membrane is disposed on a fiber. In another aspect the test solution is contacted with two or more simulated biological membranes to partition the one or more candidate compounds into the membranes.

Abstract: A method of determining a molecular descriptor of absorption for a candidate compound is disclosed. The method includes: providing a test solution comprising one or more candidate compounds; contacting the test solution with a simulated biological membrane to partition the one or more candidate compounds into the membrane detecting the presence or amount of the one or more candidate compound in the membrane at one or more permeation times; and determining a molecular descriptor of absorption using the presence or amount of the one or more candidate compound in the membrane at the one or more permeation times. In one aspect the invention provides a skin-imitating membrane, and one or more percutaneous absorption parameters are determined. In another aspect the membrane is disposed on a fiber. In another aspect the test solution is contacted with two or more simulated biological membranes to partition the one or more candidate compounds into the membranes.

Abstract: The iontophoretic device of the present invention comprises (a) a source for providing an electrical signal, (b) an electrode mounting block having a plurality of separate openings formed therein in spaced-apart relation from one another, with each of the openings configured to receive an iontophoresis electrode, (c) a plurality of iontophoresis electrodes electrically connected to the source and capable of transmitting electrical signal, each of the iontophoresis electrodes having a skin contact surface and each of the iontophoresis electrodes being received in one of the openings formed in the electrode mounting block, (d) a signal distribution network electrically connected to both the source and each of the plurality of electrodes and configured for distributing a electrical signal to each of the plurality of electrodes, and (e) a receiver connected to the source for accepting electrical signal transmitted by the plurality of electrodes, with the receiver of sufficient capacity to simultaneously accept el