Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A plush toy that is configurable to change the face displayed on the toy. In a first embodiments, the hair is moveable to display a face flap that has a different face on each side of the flap. The flap can be positioned to display either side and face or can be stowed on the back of the toy's head to display a third face. In a second embodiment, a face strap is pulled to position a first and second face on the front of the plush toy. A third embodiment includes a moveable face hood that can be positioned in one of two positions to display two different faces.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: Systems and methods are described for generating a dynamic label for a real-time communication session. An ongoing communication session is monitored to identify a content characteristic of the communication session. A size of a sliding window is determined based on the content characteristic, where the size of the sliding window defines a segment of the communication session to include in the most recent subset of communications. The most recent subset of communications is analyzed to identify relevant words based on one or more relevancy criteria. A dynamic label associated with the communication session is generated, where the dynamic label includes at least a selected one of the relevant words.

Abstract: Methods for synthesis of high surface area porous silicon-based materials and structures that can be formed according to the methods are described. Methods are scalable and capable of producing large quantities of the high surface area materials with high efficiency. The high surface area products can be in the form of a 3D network of interconnected arms or quills with multimodal porosity including high level pores between and among arms, hollow cores of the arms of the network, and pores through the walls of the arms of the network.

Abstract: The invention provides a composition of glucocerebrosidase, such as velaglucerase alfa, and isofagomine, in a molar ratio of at least about 1:2.5. Also provided is a use of the composition for treatment of a disorder related to a dysfunction in a GCase pathway. The disorder could be a lysosomal storage disease, such as Gaucher disease, Fabry disease, Pompe disease, a mucopolysaccharidoses, or multiple system atrophy. The disorder could also be a neurodegenerative disorder, such as Parkinson disease, Alzheimer's disease, or Lewy body dementia. The composition can have 0.5 to 5.0 mg/kg of glucocerebrosidase and isofagomine in at least about a 3-fold molar excess to the glucocerebrosidase. The composition can be administered intravenously or subcutaneously.

Abstract: A plush toy that is configurable to change the face displayed on the toy. In a first embodiments, the hair is moveable to display a face flap that has a different face on each side of the flap. The flap can be positioned to display either side and face or can be stowed on the back of the toy's head to display a third face. In a second embodiment, a face strap is pulled to position a first and second face on the front of the plush toy. A third embodiment includes a moveable face hood that can be positioned in one of two positions to display two different faces.

Abstract: Methods for synthesis of high surface area porous silicon-based materials and structures that can be formed according to the methods are described. Methods are scalable and capable of producing large quantities of the high surface area materials with high efficiency. The high surface area products can be in the form of a 3D network of interconnected arms or quills with multimodal porosity including high level pores between and among arms, hollow cores of the arms of the network, and pores through the walls of the arms of the network.

Abstract: The invention provides a composition of glucocerebrosidase, such as velaglucerase alfa, and isofagomine, in a molar ratio of at least about 1:2.5. Also provided is a use of the composition for treatment of a disorder related to a dysfunction in a GCase pathway. The disorder could be a lysosomal storage disease, such as Gaucher disease, Fabry disease, Pompe disease, a mucopolysaccharidoses, or multiple system atrophy. The disorder could also be a neurodegenerative disorder, such as Parkinson disease, Alzheimer's disease, or Lewy body dementia. The composition can have 0.5 to 5.0 mg/kg of glucocerebrosidase and isofagomine in at least about a 3-fold molar excess to the glucocerebrosidase. The composition can be administered intravenously or subcutaneously.

Abstract: A surgical chin strap for stabilizing a patient's head and airway to improve oxygen delivery during surgery includes a chin cup, a first cranial strap, and a second cranial strap. The chin cup is terminally connected to the first cranial strap and the second cranial strap. The chin cup is secured about a patient's chin, while the free ends of the first cranial strap and the second cranial strap are affixed to a table. The first cranial strap includes a first fastener and a first plurality of restraining holes for securing the first cranial strap to the table. The second cranial strap includes a second fastener and a second plurality of restraining holes for securing the second cranial strap to the table. A third cranial strap may be used to stabilize the patient's forehead; the third cranial strap running perpendicular to the first cranial strap and the second cranial strap.

Abstract: Techniques are disclosed herein for a lighting interface system configured to adjust tunable lighting characteristics output by one or more lighting devices based on a plurality of simple, intuitive touch-gestures without necessarily providing visual indicators via a display screen or other feedback elements. The lighting interface system is implemented as a relatively simple touchpad device that is wall-mounted or portable depending on a desired configuration. The lighting interface system is configured to capture user-gestures via the touchpad device and translate the same into target lighting characteristics and an adjustment value to adjust each of the target lighting characteristics thereby. User gestures are adjustably mapped to lighting characteristics including, for example, intensity, color temperature, hue and color saturation.

Abstract: Techniques are disclosed herein for a lighting interface system configured to adjust tunable lighting characteristics output by one or more lighting devices based on a plurality of simple, intuitive touch-gestures without necessarily providing visual indicators via a display screen or other feedback elements. The lighting interface system may be implemented as a relatively simple touchpad device that may be wall-mounted and/or portable depending on a desired configuration. The lighting interface system may be configured to capture user-gestures via the touchpad device and translate the same into target lighting characteristics and an adjustment value to adjust each of the target lighting characteristics thereby. User gestures may be adjustably mapped to lighting characteristics including, for example, intensity, color temperature, hue and color saturation.

Abstract: Techniques are disclosed herein for a lighting interface system configured to adjust tunable lighting characteristics output by one or more lighting devices based on a plurality of simple, intuitive touch-gestures without necessarily providing visual indicators via a display screen or other feedback elements. The lighting interface system is implemented as a relatively simple touchpad device that is wall-mounted or portable depending on a desired configuration. The lighting interface system is configured to capture user-gestures via the touchpad device and translate the same into target lighting characteristics and an adjustment value to adjust each of the target lighting characteristics thereby. User gestures is adjustably mapped to lighting characteristics including, for example, intensity, color temperature, hue and color saturation.

Abstract: Techniques are disclosed for manipulating both colored and tunable white lighting systems in order to enhance visual comfort and allow an observer's eyes to recover from exposure to colored light. A lighting system may gradually adjust the color, color temperature, and intensity of various multi-chip LED panels in order to provide pleasant and acceptable changes in light settings. Instead of abruptly switching from one light setting to another, a lighting system may fade to an intermediate transition setting and subsequently fade to the final light setting, allowing an observer's eyes time to adapt to the new light settings. In one example, switching from blue light to a neutral white light may involve a gradual fading from blue light, to a cool white light, and then to a neutral white light, thus allowing the end user's eyes to adapt to the new light settings.

Abstract: Particular embodiments generally relate to displaying database time using a treemap. A set of database time values is determined for a set of dimensions. The database time values measure performance of one or more databases by the time the database takes to respond to a request. The set of database time values is correlated to a set of cells in the treemap. A size of the cell is determined based on the database time value associated with it. For example, the database time value is correlated to an area of the cell. A layout of the set of cells is determined and the treemap is displayed using the layout. For example, the largest values of database time may be shown with the largest sized cells. This makes it easier for an administrator to review and analyze the database performance across multiple dimensions and determine problem areas affecting the performance of the one or more databases.

Abstract: Particular embodiments generally relate to displaying database time using a treemap. A set of database time values is determined for a set of dimensions. The database time values measure performance of one or more databases by the time the database takes to respond to a request. The set of database time values is correlated to a set of cells in the treemap. A size of the cell is determined based on the database time value associated with it. For example, the database time value is correlated to an area of the cell. A layout of the set of cells is determined and the treemap is displayed using the layout. For example, the largest values of database time may be shown with the largest sized cells. This makes it easier for an administrator to review and analyze the database performance across multiple dimensions and determine problem areas affecting the performance of the one or more databases.

Abstract: Metal halide lighting with good color during dimming may be obtained. An appropriate balance of commonly used metal halides (NaI, DyI3, CeI3, CaI2, TlI) is dosed in the lamp. No mercury is used. A higher than typical xenon fill pressure from 50 to 500 Kilopascals may be used to help control thermal properties and voltage. If necessary, modulation of the power at acoustic resonance frequencies may be used to straighten and center the arc. Efficient and pleasant white output is obtained. As the power is reduced, the chromaticity either (1) remains fairly constant or (2) drifts acceptably towards warm pinkish colors. Large factors of attenuation in output can be realized. The lumen output was reduced by at least a factor of twenty in one sample as the power was dimmed from 70 to 20 watts.

Abstract: A discharge lamp system and method of operating a discharge lamp system in which vertical segregation of vapor phase species is reduced. Lamp power is modulated with an arc-straightening frequency and with a frequency that excites a combination radial plus longitudinal acoustic mode of the lamp. The combination radial plus longitudinal acoustic mode may be a combination first radial mode and nth longitudinal acoustic mode and may be excited with a single power frequency or a swept power frequency range. The two frequencies may be provided at the same time, or separately where the modulation at the arc-straightening frequency is 2 to 16 times longer than a subsequent modulation at the combination radial plus longitudinal acoustic mode.