Patents by Inventor Nancy E. Lee

Nancy E. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Catalytic asymmetric reduction of trisubstituted olefins
    Patent number: 5491233
    Abstract: A catalytic asymmetric reduction process, which, by hydrogenating trisubstituted olefins, yields a corresponding organic compound having a high level of enantiomeric purity is disclosed. The process is also effective for the catalytic asymmetric reduction of certain enamines and related compounds to yield a corresponding amine or related compound, respectively, having a high level of enantiomeric purity. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex that is selected from groups 3, 4, 5, or 6, lanthanides and actinides. Moreover, the process uses hydrogen as the stoichiometric reducing agent and may be carried out at pressures ranging from about 0.5 to 200 atmospheres. The reaction can also be carried out using an acidic compound as a rate enhancing additive.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: February 13, 1996
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Richard D. Broene, Nancy E. Lee
  • Catalytic asymmetric reduction of enamines
    Patent number: 5489682
    Abstract: A catalytic asymmetric reduction process, which, by hydrogenating enamines, yields a corresponding amine having a high level of enantiomeric purity is disclosed. The reduction process utilizes a chiral metal catalyst that includes a metal or metal complex that is selected from groups 3, 4, 5, or 6, lanthanides and actinides. Moreover, the process uses hydrogen as the stoichiometric reducing agent and may be carried out at pressures ranging from about 0.5 to 200 atmospheres.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: February 6, 1996
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen L. Buchwald, Nancy E. Lee
  • 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolytic activity
    Patent number: 5021569
    Abstract: 4-Azatricyclo[4.3.1.1(3,8)]undecylarylpiperazine compounds of this invention demonstrated affinity for the 5-hydroxytryptamine-1A receptor site (5-HT.sub.1A) and to a lesser extent, for dopamine-2 receptor sites (D.sub.2). Compounds with such a profile provide a treatment for CNS disorders such as anxiety, depression, and sexual disturbances without EPS liability.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: June 4, 1991
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Nancy E. Lee
  • 2-pyridinecarbothioamides, processes for preparation thereof and pharmaceutical compositions comprising the same
    Patent number: 4958023
    Abstract: There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: September 18, 1990
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Nancy E. Lee
  • 2-Pyridinecarbothioamides and pharmaceutical compositions comprising the same
    Patent number: 4873238
    Abstract: There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
    Type: Grant
    Filed: September 19, 1988
    Date of Patent: October 10, 1989
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Nancy E. Lee