Patents by Inventor Nancy Hsiung

Nancy Hsiung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cells, vectors and methods for producing biologically active heterodimeric proteins
    Publication number: 20030059898
    Abstract: Biologically active heteropolymeric protein composed of a plurality of subunits, both subunits being synthesized in a single cell having an expression vector comprising heterologous DNA encoding the subunits. Preferably the protein is similar to the human or ungulate fertility hormones, LH and FSH.
    Type: Application
    Filed: August 26, 2002
    Publication date: March 27, 2003
    Applicant: Genzyme Corporation
    Inventors: Anton Beck, Edward Bernstine, Nancy Hsiung, Vermuni B. Reddy
  • Cells, vectors and methods for producing biologically active TSH
    Patent number: 6455282
    Abstract: Biologically active heteropolymeric protein composed of a plurality of subunits, both subunits being synthesized in a single cell having an expression vector comprising heterologous DNA encoding the subunits. Preferably the protein is similar to the human or ungulate fertility hormones, LH and FSH.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: September 24, 2002
    Assignee: Genzyme Corporation
    Inventors: Anton Beck, Edward Bernstine, Nancy Hsiung, Vermuni B. Reddy
  • Nucleic acids encoding and recombinant production of the .beta. subunit of lutenizing hormone
    Patent number: 5856137
    Abstract: Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: Genzyme Corporation
    Inventors: Vermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward George Berstine
  • Recombinant heterodimeric human fertility hormones, and methods, cells, and vectors and DNA for the production thereof
    Patent number: 5767251
    Abstract: Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.
    Type: Grant
    Filed: January 22, 1993
    Date of Patent: June 16, 1998
    Assignee: Genzyme Corporation
    Inventors: Vermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward George Bernstine
  • DNA encoding the beta subunit of human follide stimulating hormone and expression vectors and cells containing same
    Patent number: 5639640
    Abstract: The correct sequence is disclosed for the beta subunit of human follicle stimulating hormone which, when present in a recombinant heterodimeric human fertility hormone allows the production of biologically active hormone. DNA coding for such beta subunit of human FSH may thus be prepared as well as expression vectors containing such DNA and cells transfected therewith.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 17, 1997
    Assignee: Genzyme Corporation
    Inventors: Vermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward George Bernstine
  • Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
    Patent number: 5639639
    Abstract: Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subunit being controlled by a separate promoter. Preferred human fertility hormones include hCG, hLH and hFSH.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: June 17, 1997
    Assignee: Genzyme Corporation
    Inventors: Vermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward George Bemstine
  • Human uterine tissue plasminogen activator produced by recombinant DNA
    Patent number: 5344773
    Abstract: A replicable expression vector capable, in a transformed host mammallian cell, of expressing a DNA sequence encoding active human TPA which, when expressed in the host cell, yields active TPA which lacks one or more of the TPA-bound N-linked carbohydrate moieties of naturally occurring human TPA.
    Type: Grant
    Filed: October 1, 1985
    Date of Patent: September 6, 1994
    Assignee: Genzyme Corporation
    Inventors: Cha-Mer Wei, Nancy Hsiung, Vermuri B. Reddy, Jeffrey F. Lemontt, William Dackowski, Richard Douglas, Edward S. Cole, Richard D. Purcell, Jr., David Tai-Yui Lau
  • Follicle stimulating hormone
    Patent number: 5156957
    Abstract: Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: October 20, 1992
    Assignee: Genzyme Corporation
    Inventors: Vemuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward G. Berstine
  • FSH
    Patent number: 4923805
    Abstract: Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.
    Type: Grant
    Filed: January 30, 1985
    Date of Patent: May 8, 1990
    Assignee: Integrated Genetics, Inc.
    Inventors: Vemuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward G. Berstine
  • Heteropolymeric protein
    Patent number: 4840896
    Abstract: Biologically active heteropolymeric protein composed of a plurality of subunits, each subunit being synthesized by a cell having an expression vector heterologous DNA encoding the subunit.
    Type: Grant
    Filed: November 2, 1983
    Date of Patent: June 20, 1989
    Assignee: Integrated Genetics, Inc.
    Inventors: Vermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward G. Bernstine
  • Vector encoding hepatitis B surface antigen
    Patent number: 4696898
    Abstract: Recombinant DNA vector including (1) a promoter for a eukaryotic metalliothionein gene ligated to a gene sequence encoding hepatitis B surface antigen, and (2) at least the 69% transforming region of the bovine papilloma genome, expression of the hepatitis B surface antigen encoding gene sequence being under the control of the metallothionein promoter.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: September 29, 1987
    Assignee: Integrated Genetics, Inc.
    Inventors: Renee A. Fitts, Nancy Hsiung, Dean H. Hamer