Patents by Inventor Nancy J. Casna

Nancy J. Casna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant DNA process for producing useful polypeptides
    Patent number: 4845031
    Abstract: The subject invention concerns a process for stabilizing foreign proteins within the cell of E. coli microbes infected with genetic elements encoding said protein production.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: July 4, 1989
    Assignee: The Research Foundation of State University of New York
    Inventors: David A. Shub, Nancy J. Casna
  • Method for locating and purifying DNA containing single base mismatches
    Patent number: 4794075
    Abstract: A method for distinguishing fragments of DNA which contain single base mismatches from their perfectly paired homologues is disclosed. Single stranded regions within a duplex fragment are modified with carbodiimide, which reacts with unpaired guanine (G) and thymine (T) residues in DNA. Linear duplex DNA molecules do not react, while DNA molecules with single base mismatches react quantitatively with carbodiimide. Following reaction with carbodiimide, the DNA molecules are fractionated on high percentage polyacrylamide gels such that modified and unmodified fragments can be clearly distinguished. Application of this technique in order to located and purify DNA sequence differences responsible for phenotype variation and inherited disease is disclosed.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: December 27, 1988
    Assignee: Lifecodes Corporation
    Inventors: John P. Ford, David F. Novack, Nancy J. Casna